Fitness-conscious people often face the challenge of losing fat from the abdomen. Even strict food regimes and exercise do not help to lose truncal obesity. With the advancement of medical knowledge, a new peptide called Tesamorelin is now available to help overcome stubborn fat with minimal adverse effects on the body.

What is Tesamorelin?

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) and comprises 44 amino acids and a trans-3-hexenoic acid group. The peptide promotes weight loss and can be used with medical recommendations only. Theratechnologies was the first organization who manufactured the peptide with the brand name of EGRIFTA.

The importance of growth-hormone-releasing-hormone

The hypothalamus in the brain secretes GHRH. Hypothalamus is a significant gland that regulates diverse physiological functions including hormonal release and regulation of body temperature. The secreted GHRH in turn stimulates the release of growth hormone (GH) from the pituitary gland of our body.

The efficiency of the peptide depends on the amino acid composition of GHRH combined with 3-hexanoic acid moiety. The moiety works like a plant metabolite and hence is safe for ingestion. Tesamorelin was approved for use in November 2010. The peptide helps to lose fat in HIV patients as the antiretroviral drugs often induce lipodystrophy. Bodybuilders and fitness enthusiasts also use it to lose abdominal fat upon regular use.

How does Tesamorelin work?

The peptide just like its natural counterpart promotes the release of GH from the pituitary gland. GH in turn promotes lipolysis or metabolism of stored lipids and triglycerides in the body. Lipids and triglycerides are versions of fat that are stored in our body for a future source of energy. Hence high levels of the same increase risk of cardiac disease. Tesamorelin reduces visceral fat around the abdomen. Studies on HIV patients with lipodystrophy show that the molecule can reduce abdominal fat by about seventeen percent within twenty-six weeks. It also decreases liver fat by up to eighteen percent.

The recommended dose of Tesamorelin in average adults is 2 mg each day. It can be injected beneath the naval region while avoiding any region of scarring or bruising. The drug should be used immediately upon reconstitution. The lyophilized drug can be stored between 36 and 46 degrees Fahrenheit. The peptide solution should be used only if it is clear and free of particles upon reconstitution.

Other Lesser Known Benefits of Tesamorelin

The peptide not only improves the body’s natural ability to secrete GH but also has far less side effects compared to other GHRH secretagogues. The peptide reduces belly fat as well as confers additional benefits. It has been found to improve cognitive function on individuals aged between 55 and 87 during the course of administration of the drug.

Side Effects of Using Tesamorelin

Tesamorelin has been found to be potentially safe for human consumption. However, it is important to be cognizant of the mild side effects which have been observed. These side effects are as follows:
Redness, swelling, or irritation at the site of injection.
Muscle pain
Nausea or vomiting
Mild itchiness

The peptide might have cross-reactivity with certain drugs. Hence medical consultation is crucial before the use of the molecule. Cholesterol medications such as Zocor and HIV-antiretroviral drugs such as Norvir can show adverse effects when used with the drug.

Other Things to Consider

Tesamorelin cannot be used by pregnant women or by those who are planning to conceive. Visceral fat is required for pregnancy. The drug promotes fat metabolism and thus is unsuitable during pregnancy. Medical consultation is also recommended for use of the molecule for diabetic patients. It increases the levels of insulin growth factor 1 (IGF-1). This can lead to fluctuations in blood sugar levels. Such a situation will demand constant monitoring of blood sugar.
In a nutshell, Tesamorelin turns out to be a wonder drug for fitness enthusiasts and bodybuilders. It helps in the metabolism of difficult abdominal fat and helps to achieve fitness goals faster. By triggering the release of growth hormone, it improves the general metabolism and energy homeostasis of the body. The peptide has diverse beneficial influences such as improving cognitive capabilities with only minimal side effects. The amino acid composition and the hexanoic acid modification confers the beneficial functions to the peptide similar to growth-hormone-releasing-hormone. In fact, the short stretch of the peptide helps to overcome the adverse effects of excess full-length GHRH. However, the peptide has to be used upon medical recommendation only and is not recommended for pregnant ladies and diabetic patients.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

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