Tesamorelin and Ipamorelin Findings

Tesamorelin and Ipamorelin are synthetic peptides that stimulate the release of growth hormones.

What is Tesamorelin?

Tesamorelin is also known as (TH9507. It is a synthetic growth hormone-releasing factor agonist that stimulates the production and release of endogenous growth hormone. It comprises all 44 amino acids of human GHRH with a trans3-hexenoic acid group. It is also more robust and stable than GHRH and is resistant to cleavage by the dipeptidyl aminopeptidase enzyme.

Tesamorelin has reduced triglyceride and total cholesterol levels in subjects with lipodystrophy associated with antiretroviral therapy for HIV infection. Researchers also evaluate Tesamorelin to treat insulin resistance, obesity, and non-alcoholic fatty liver disease.

C221H366N72O67S is the empirical formula for tesamorelin, and it has a molecular weight of 5136g/mol.

Mechanism of Action

Tesamorelin activates the GHRH receptor in the pituitary gland, causing the synthesis and release of growth hormone-releasing hormone. Growth hormone-releasing hormone acts on several cells in the body, including hepatocytes, to stimulate the production of insulin-like growth factor 1 (IGF1). IGF1 mediates many of the effects of growth hormones. These include liver growth, suppression of programmed cell death, impaired glucose tolerance, and lipolysis.

What is Ipamorelin?

Ipamorelin is a synthetic pentapeptide with distinct and specific growth hormone (GH) release properties as powerful and effective as GHRP6. Ipamorelin stimulates GH release via GHRP-like receptors. Surprisingly, it does not release ACTH or cortisol at levels significantly different from those observed after GHRH stimulation. This action makes ipamorelin the first GHRH agonist specific for GH release, similar to GHRH.

C38H49N9O5 is its empirical formula, and it has a molecular weight of 711.9 g/mol.

Mechanism of Action

Ipamorelin works in a completely different way to stimulate the release of growth hormones. It binds to ghrelin receptors in the pituitary gland without affecting other hormones in the body. Ghrelin has profound metabolic regulatory effects, including increased or decreased hunger, suppression of the breakdown of accumulated fat, and most importantly, the release of growth hormone from the pituitary gland.

Ipamorelin stimulates the body to produce GH, so it does not interfere with natural growth hormone production with synthetic HGH. Ipamorelin induces GH secretion in a manner that is closer to the spontaneous emission pattern, allowing growth hormones to be released in a “pulsatile” mode rather than constantly rising.

Potential effects of Tesamorelin and Ipamorelin

Research has shown that Tesamorelin and Ipamorelin peptides don’t affect different pituitary hormones, inclusive of thyroid-stimulating hormone (TSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and prolactin.

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