Tesamorelin or Ipamorelin for Growth Hormone Delivery?

by | Mar 9, 2022 | Research

Tesamorelin and Ipamorelin are synthetic peptides that stimulate the release of growth hormones. However, one can do this in a variety of ways.

What is Tesamorelin?

Tesamorelin is also known as (TH9507. It is a synthetic growth hormone-releasing factor agonist that stimulates the production and release of endogenous growth hormone. It comprises all 44 amino acids of human GHRH with a trans3-hexenoic acid group. It is also more robust and stable than GHRH and is resistant to cleavage by the dipeptidyl aminopeptidase enzyme.

Tesamorelin has reduced triglyceride and total cholesterol levels in subjects with lipodystrophy associated with antiretroviral therapy for HIV infection. Researchers also evaluate Tesamorelin to treat insulin resistance, obesity, and non-alcoholic fatty liver disease.

C221H366N72O67S is the empirical formula for tesamorelin, and it has a molecular weight of 5136g/mol.

Mechanism of Action

Tesamorelin activates the GHRH receptor in the pituitary gland, causing the synthesis and release of growth hormone-releasing hormone. Growth hormone-releasing hormone acts on several cells in the body, including hepatocytes, to stimulate the production of insulin-like growth factor 1 (IGF1). IGF1 mediates many of the effects of growth hormones. These include liver growth, suppression of programmed cell death, impaired glucose tolerance, and lipolysis.

What is Ipamorelin?

Ipamorelin is a new and potent synthetic pentapeptide with distinct and specific growth hormone (GH) release properties as powerful and effective as GHRP6. Ipamorelin stimulates GH release via GHRP-like receptors. Surprisingly, it does not release ACTH or cortisol at levels significantly different from those observed after GHRH stimulation. This action makes ipamorelin the first GHRH agonist specific for GH release, similar to GHRH.

C38H49N9O5 is its empirical formula, and it has a molecular weight of 711.9 g/mol.

Mechanism of Action

Ipamorelin works in a completely different way to stimulate the release of growth hormones. It binds to ghrelin receptors in the pituitary gland without affecting other hormones in the body. Ghrelin has profound metabolic regulatory effects, including increased or decreased hunger, suppression of the breakdown of accumulated fat, and most importantly, the release of growth hormone from the pituitary gland.

Ipamorelin stimulates the body to produce GH, so it does not interfere with natural growth hormone production with synthetic HGH. Ipamorelin induces GH secretion in a manner that is closer to the spontaneous emission pattern, allowing growth hormones to be released in a “pulsatile” mode rather than constantly rising. This way has fewer side effects compared to synthetic HGH. Ipamorelin produces smoother, less intense GH emission pulses with a longer duration than most other GHRPs, resulting in a GH increase of up to 3 hours after administration.

Effects of Tesamorelin and Ipamorelin

Clinical research displays that Tesamorelin and Ipamorelin peptides don’t affect different pituitary hormones, inclusive of thyroid-stimulating hormone (TSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and prolactin.

Tesamorelin causes, among other things, elevated IGF1 levels, impaired glucose tolerance, and hypersensitivity reactions. The possible side effects of ipamorelin are similar to those of tesamorelin.

Some of the benefits of tesamorelin are associated with the breakdown of lipids and triglycerides. This association includes reductions in triglyceride levels, visceral fat, and carotid artery size. Benefits of Ipamorelin include improved inflammation, anti-aging properties, and loss of appetite, resulting in faster weight loss.

Side Effects of Tesamorelin and Ipamorelin

The industry recognizes Ipamorelin as the most tolerated growth hormone secretagogue. The side effects are usually mild and dose-dependent, and moderate doses rarely cause side effects.

General Side Effects Include:

– slight flushing

– headache 

– Temporary nausea and disillusioned belly

– Emotions of tiredness or lethargy 

Tesamorelin can exhibit allergic reactions like difficulty breathing, hives, swelling of lips, face, tongue, or throat.

Serious Side Effects include:

– swelling in your hands, ankles, or feet

– pain or stiffness in your muscles or joints

– pain in your arms or legs

– wrist pain or numbness

– numbness or tingling in your hands or fingers

– pounding heartbeats or fluttering in your chest

– high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss)

Less Serious Side Effects include:

– Insomnia; Depressed mood

– Itching or mild rash

– Muscle spasm

– Night sweats

– Upset stomach

– Nausea and Vomiting

Tesamorelin should not be used during pregnancy as it can cause congenital disabilities or harm the unborn baby.


Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.