The use of peptides to treat various medical conditions is not new. It has gained momentum over the past few years, especially for weight loss.
For many years, peptides have been used to treat medical conditions like diabetes and various skin conditions. Earlier, peptides were made by replicating a naturally occurring peptide that the body lacked. These synthetic peptides were then introduced into the system to produce their particular effects.
The goal has now shifted towards creating derivatives of the natural peptides, which can be altered in different ways to fit into the already existing metabolic pathways and bring about changes.
While formulating peptides for weight loss, the goal has been to look for a peptide that will not alter the body mass but will only help burn the excess fat. This new approach has resulted in the formulation of the below-discussed peptides that have revolutionized weight loss for people.
How Can Peptides Help With Weight Loss?
Utilizing peptides for losing weight is a paradigm change in the industry. Past weight loss medicines generally focused on ramping up metabolism at a systems level, increasing the body’s utilization of calories. This broad approach does not distinguish between calories from fat and calories from different tissues, including muscle. It stimulates weight loss, but often not the targeted fat burning that people desire.
Targeted burning of fat is just one of the benefits of peptides.
Peptides interact with the body’s natural chemistry to alter how calories are used and stored. This process can help drive calorie use away from fat storage and muscle and bone building. This process also results in a two-factor approach to “losing weight” that enhances metabolism in adipose tissue while shunting calories toward more active bone and muscle building.
The selection of peptides in this article has undergone extensive research investigating their weight loss properties. The FDA currently approves some for specific indications while others undergo medical investigations. What should be considered is how many peptides fall into this category and the fact that they usually have different secondary effects that may make them suited for specific indications.
Fragment 176-191 (Growth Hormone Analogue)
Fragment 176-191 peptide is a tiny segment of human growth hormone (HGH) and is usually referred to as the “lipolytic fragment.” The title was coined due to research on animal systems proving that Fragment 176-191 betters fat metabolism in genetically engineered obese lab subjects.
Human growth hormone (HGH) therapy has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promoting long bone growth, and enhanced insulin-like growth factor-1(GF-1) levels. Intense animal studies have proven that the artificial fragment betters the lipolytic results of hGH sans, generating the same adverse effects. Consequently, the peptide can be used for anti-obesity treatments.
AOD 9604 (Growth Hormone Analogue) Can Be Used For Weight Loss
AOD 9604 is a modified peptide initially created for the therapy of obesity. It changes the peptide fragment 176-191 of human growth hormone (HGH). Moreover, the mode of action of AOD 9604 is restricted to promoting lipolysis in the body, making it a popular choice for treating obesity. The peptide does not affect levels of insulin or IGF1 in the body. Therefore, using AOD 9604 does not trigger a clinical risk of developing diabetes or intolerance toward glucose.
Further, being structurally similar to HGH, it does not induce immunogenic reactions and is immunologically safe. Research from Australia shows that AOD 9604 increases weight loss 3-fold compared to placebo. It affects beta-3-adrenergic receptors on white fat to boost fat breakdown and might indirectly activate apoptosis (programmed cell death) in fat white cells. AOD1604 is one of the most efficient peptides for weight loss yet developed, with studies showing as much as a 50% reduction in weight gain over just three weeks of administration.
Semaglutide (GLP-1 Agonist)
Semaglutide (GLP-1) and glucagon-like peptide 1 are short, naturally occurring peptides. The hormone is only 3031 amino acids in length. Its primary physiological function is to lower blood sugar levels by naturally increasing insulin secretion. It also protects beta-cell insulin stores by promoting transcription of insulin genes and is associated with neurotrophic effects in the central nervous system and the brain. The GI system has shown that Semaglutide significantly reduces appetite by slowing gastric emptying and bowel motility. Preliminary studies have also demonstrated the effects of Semaglutide on the heart, fat, muscles, bones, liver, lungs, lungs, kidneys, and weight loss.
Growth Hormone Secretagogues
GH secretagogues are peptides or nonpeptidic agents that release HGH from the pituitary. High GH levels lead to increased fat burning and enhanced muscle and bone growth. HGH levels also alter appetite and have been shown to increase rates of wound healing, cardiovascular fitness, bone strength, and more. These include the following essential peptides.
Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.