Topical Tripeptide -29 as a Synthetic Equivalent to Collagen

by | Jun 15, 2022 | Research

The synthetic equivalent of one of collagens constituent units is tripeptide-29. Tripeptide-29 serves as a building block for large collagen molecules. As a result, it can change the amino acid sequence and relative frequency of a collagen molecule, including its superstructure, tertiary, and quaternary properties. It is important to remember that collagen is vital to wound healing and tissue control.

According to research, tripeptide-29 can have a wide range of physiological effects.

The Research History of Tripeptide-29

According to in vitro research, Tripeptide-29 is a limited antagonist of collagen receptor-GPVI. Platelet surfaces are packed with GPVI, the protein responsible for the early production of blood clots. Collagen fibers are referred to as thrombogenic in this context because they play a significant part in the collagen-mediated stimulation of the collection of collagen in vascular tissues, which is the first stage in tissue repair and clot formation.

Tripeptide-29 boosts GPVI activation, suggesting it could be useful in discovering how to create a perfect clotting environment in cases of bleeding and clotting abnormalities.

The Roles of Tripeptide-29 (Topical)

Collagen is one of the most common compounds found in animals. All animals, reptiles, humans, fish, birds, and even algae contain it. It plays a role in muscle fibers, skin, ligament and tendon structures, bone, teeth, scar formation, cartilage, cell signaling, transmembrane proteins like integrin and fibronectin, placental structure, and the vitreous humor of the eye.

  • The Regulation of Tissue Fibrosis: Tripeptide-29 suppresses the activity of dipeptidyl peptidase-IV in vitro utilizing fish scales, bovine skin, pig skin, and chicken feet (DPP4). DPP4 is a cell apoptosis enzyme identified in immunological signaling cells. Growth factors, neuropeptides, chemokines, and vasoactive peptides are all hampered by it since it is an inherent element of cell membranes. Its duties are not restricted since it is involved in glucose metabolism, where it breaks down incretins—a hormone that aids in lowering blood glucose.

DPP4 studies in animal models show that it fosters fibrotic growth in organs such as the liver and kidney. Tripeptide-29 can increase cellular glucose absorption and minimize renal fibrosis while also inhibiting DPP4 activity. As a result, various research pathways have opened up, not only for the treatment of diabetes but also as pathologic sequelae.

  • The effect of Tripeptide-29 on Collagen Stability: Tripeptide-29, according to studies, may be effective in modulating collagen stability. It has also allowed scientists to realize that the final peptide in the tripeptide monomer modulates the superior collagen structure (in an A-B-C trend, C has the most influential capacity on collagen stability).
  • The Effect of Tripeptide-29 on Skin Tone: The significance of tripeptide-29 in the protection of the skin against the aging process has been the subject of recent studies. The research on Tripeptide-29 reveals promising results in the reduction of aging by improving contour, reducing skin deformation, and improving moisture. It enhances skin tone by smoothing skin texture and preventing brown and red patches from appearing. In 90 percent of the animal research, treatment of Tripeptide-29 resulted in better moisturization while increasing flexibility.

Topical tripeptide-29 synergy with certain hexapeptides improves skin turnover and reduces fine wrinkles, eye hollowing, eye bags, and crow’s feet.

  • Tripeptide-29 is an effective Radical Scavenger: Damage caused by free radicals is the fundamental cause of tissue and cellular aging. Though the body has various protections in place to counteract the consequences of free radical damage, these barriers grow less effective with time. According to studies, Tripeptide-29 hydrolysate is a potent radical scavenger.

Side effects of Tripeptide-29

Tripeptide-29 is a collagen peptide, and its activities, like other collagen peptides, can have destructive consequences. The major side effects with the use of Tripeptide-29 include:

  • Constipation: This may result from excessive protein consumption when the gut doesn’t have enough fluid and fiber.
  • Diarrhea: May arise when the body processes excessive collagen proteins beyond its capacity.
  • Kidney stones: The risk of kidney stones are primarily seen in patients that consume collagen peptide because collagen peptides contain an amino acid termed hydroxyproline. Hydroxyproline can be a risk factor and trigger the formation of kidney stones.
  • Drug Interactions: The hydrolysate of collagen may interfere with the effects of a drug regime and render them ineffective.
  • Allergic Reactions: Collagen peptides and hydrolysates may cause allergic reactions such as skin breakouts etc.


Tripeptide-29 is a collagen peptide with potential benefits in animal models. However, this chemical is limited to educational and scientific purposes, not for human consumption.

Consult your physician in cases requiring the intervention of such peptides.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.