Anti-Cancer Properties of Tiptorelin Peptides

by | Jun 17, 2022 | Research

Triptorelin is a synthetic equivalent of the Gonadotropin-Releasing Hormone. The peptide is used in clinical settings to treat advanced prostate cancer as a factor in approaching androgen-deprivation remedial treatment.

Identical to its effects on Luteinizing Hormone-Releasing Hormone, it is an active inhibitor of estrogen and testosterone synthesis on continuous Triptorelin supplementation over a long period.

In the USA, this peptide is used to censor the synthesis and production of estrogen and testosterone in transgender individuals. Triptorelin can also be used to treat breast cancer in premenopausal women.

It is important to note that the effects of Triptorelin are dependent on the manner of administration.

The Roles and Benefits of Triptorelin

The Role of the Compound in Testosterone Secretion
As stated earlier, the peptide effect is dependent on the manner of administration.

According to research, the peptide increases testosterone levels with prolonged administration and represses production after chronic exposure to the peptide. This testosterone flare occurs during the first few weeks of triptorelin administration. As a result, Triptorelin may be vital in enhancing testosterone levels in some men depending on the dosage and time of administration.

The Effects of Triptorelin are Dependent on its Application
Triptorelin is a synthetic equivalent of GnRH. Therefore, it can enact the anterior pituitary gland to release Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH). If, however, triptorelin is administered in a steady-state format and not in a pulsatile way, it may eventually suppress the secretion of LH, FSH, testosterone and estrogen.

This asserts that Triptorelin’s effect is dependent on the supplementation method.

Roles of Triptorelin in Breast Cancer
Hormone suppression is one of the pillars of treating hormone-sensitive cancers in modern breast cancer treatment.

Currently, it is used in a surgical setting to reduce tumors before surgery. Tamoxifen therapy decreases the risk of breast cancer by 40-50 percent in postmenopausal women and 30-50 percent in premenopausal women.

Administration of Tamoxifen causes side effects such as tumor resistance to the Tamoxifen. The resistance leads scientists searching for a better adjuvant, thus, investigating the roles of Triptorelin in breast cancer.

The peptide, added to letrozole or zoledronic acid, enhances premenopausal women’s survival rates more than Tamoxifen. The addition of Tamoxifen to Triptorelin betters’ disease control and improves survival in breast cancer, particularly in high-risk patients that undergo chemotherapy.

The Roles of the Compound in the Treatment of Prostate Cancer
Triptorelin functions primarily in the treatment of prostate cancer, where it lowers cancer growth by causing a decrease in testosterone levels. Triptorelin decreases the 10-year death rate in hormone-sensitive prostate cancer to less than 5% while reducing the need for surgery. Still, plans are in place to bolster the benefits of Triptorelin by adding other adjuvants to it.

Recent research posits that GnRH in symbiont with radiotherapy can show similar benefits as total androgen blockade. The blockade of androgen has several side effects. Reducing the side effects and preserving potency can improve the standard of life and boost treatment adherence.

Triptorelin showed positive results in reducing urinary tract symptoms in men with prostate cancer, bringing the frequency of the symptoms from about 54% to about 12%. These results posit that Triptorelin may help treat benign prostatic hyperplasia and other medical ailments that interfere with urinary function in men.

Protection of Fertility
Chemotherapy causes infertility, particularly in younger individuals. The administration of this peptide in young men that undergo chemotherapy shows that the peptide can preserve fertility in some patients.

Research also shows that Triptorelin can reduce the prevalence of early menopause in patients that have undergone chemotherapy by roughly 17%. The administration of this peptide in women with Adenomyosis may increase the degree of spontaneous pregnancy and better the outcomes of the disease itself. Identical benefits are evident in women with endometriosis.

In endometriosis, triptorelin acts to reduce pain by causing a decrease in the number of nodules in the disease. Research posits that Triptorelin may improve the outcomes of laparoscopic surgery for endometriosis. It is specifically effective in increasing the rates of pregnancy after surgery.

In women with colorectal endometriosis, Triptorelin appears to decrease pain in about 80% of patients and diarrhea in about 60%. Triptorelin does not cure but makes endometriosis manageable.

Triptorelin’s role in Immune Function
Research in mouse models shows that LHRH can impact the thymus and the immune system. Aging reduces the LHRH binding sites on the thymus, resulting in a 50% reduction in thymic mass and function.

The LHRH agonist, Triptorelin, may improve proliferation within the thymus and cause a turnaround in aging effects to some extent. Therefore, Triptorelin administration may prevent the age-related changes in the thymic mass and function while improving the activities of the immune system – asserting that the peptide plays a preventive/therapeutic role.


Research determines the effects of GnRH in oncology and the role of sex hormones in cancer succession. However, preliminary research is ongoing to identify the role of Triptorelin in restoring sexual function, testosterone levels, and fertility.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.