Studies on Syn-Coll Peptides Supporting Collagen Production

by | Jul 25, 2022 | Research

Syn-Coll, also known as Palmitoyl Tripeptide-5 or Tripeptide-5, is a peptide that promotes the production of Type I and Type III collagen while inhibiting its degradation. The peptide also reduces the appearance of wrinkles while increasing skin firmness and moisture. Palmitoyl Tripeptide-5 accomplishes all of these tasks by activating transforming growth factor-𝛃.[1]

Collagen type I is present in the bones, muscles, and skin. Type III collagen, on the other hand, is present in the skin, vascular system, and lungs. By increasing Type I and Type III collagen, Syn-Coll improves wound healing, skin strength, the vascular supply to the skin, and skin hydration.

The human skin contains a variety of cells and tissues. Fibroblasts are among the most commonly occurring cells in the skin. The main function of these cells is to produce collagen proteins. With age, the number of active fibroblasts and levels of collagen decreases. A decline in the levels of collagen leads to the appearance of signs of aging like wrinkles.

Palmitoyl Tripeptide-5, on the other hand, functions similarly to Thrombospodin-1. It stimulates transforming growth factor-induced collagen degradation.


Functions of Palmitoyl Tripeptide-5

TSP-1 is a naturally occurring peptide that increases TGF-𝛃 activities. Palmitoyl Tripeptide-5 exhibits the same characteristics as TSP-1, increasing Type I and III collagen levels in the dermal (skin) fibroblasts.[2] The researchers noted that “Investigator assessments of both periocular and perioral wrinkles showed statistically significant improvements over Baseline within minutes of initial application; these positive findings continued to improve through Months 1 and 3.” Experimental results show that Syn-Coll increases Type I and III collagen levels by 2-3 folds above the normal levels.[3] This lasts for approximately 72 hours, after which it begins to diminish.

TSP-1 is known as an extracellular matrix (ECM) protein. It cohabits with collagen and elastin in the skin. A specific part of TSP-1 is harvested for use in Palmitoyl Tripeptide-5 production. This part stimulates latent TGF-𝛃.

Just like TSP-1, Syn-Coll functions to enhance wound healing. It is active in the post-natal development of skin structures.[4]

Palmitoyl Tripeptide-5 also deactivates matrix metalloproteinases I and III (MMP1 and MMP3). Matrix metalloproteinases are enzymes that act to degrade collagen. These enzymes are beneficial, as they recycle collagen following aging, but they’re uncontrollably hiked in conditions like inflammation to abnormal levels. Due to this, premature skin damage, the prevalence of lines, wrinkles, and other aging helmets, may surface.

In terms of skin, cosmeceutical science aims to promote skin health. Skin health is improved by increasing collagen synthesis or decreasing collagen degradation. Palmitoyl Tripeptide-5 increases collagen synthesis by approximately 119%. Due to this, wrinkle appearance reduces, skin firmness increases, and fine lines decrease, causing the skin to appear younger and healthier.

Palmitoyl Tripeptide-5 not only reduces the appearance of wrinkles and fine lines, but it may also aid in reducing toxins in the body. Syn-Coll interacts with the skin and keeps toxins out. This process protects the body from the damaging effects of free radicals.

By inhibiting MMP1 and MMP3 activity, Palmitoyl Tripeptide-5 can help to prevent collagen breakdown. These results suggest that Syn-Coll can promote Type I and Type III collagen formation and inhibit collagen breakdown by the abovementioned enzymes.

In terms of wrinkle reduction, Syn-Coll is approximately 3.5 times more effective than a placebo. According to scientists, Palmitoyl Tripeptide-5 is 60% more effective than Palmitoyl Pentapeptide.[5] Its important to note that “Anatomic properties of eyelid skin require skin care products specifically suited to this area” and Palmitoyl Tripeptide-5 is one of the few peptides suitable for improving wrinkles in the area.

Palmitoyl Tripeptide-5 alters the effects of photo-aging damage. Syn-Coll also rarefies the appearance of pores. The peptide increases skin texture and enhances skin elasticity and firmness. Palmitoyl Tripeptide-5 functions as an anti-stretching peptide. It is also cold-processible.

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  1. Thorsen, M., Yde, B., Pedersen, U., Clauden, K. & Lawesson, S.-O. Studies on amino acids and peptides-V. Tetrahedron 39, 3429–3435 (1983).
  2. Trookman, N. S., Rizer, R. L., Ford, R., Ho, E. & Gotz, V. Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J. Clin. Aesthetic Dermatol. 2, 38–43 (2009).
  3. Varga, J., Rosenbloom, J. & Jimenez, S. A. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem. J. 247, 597–604 (1987).
  4. Murphy-Ullrich, J. E. & Poczatek, M. Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev. 11, 59–69 (2000).
  5. Bucay, V. W. & Day, D. Adjunctive Skin Care of the Brow and Periorbital Region. Clin. Plast. Surg. 40, 225–236 (2013).