Research of AOD 9604 in Fat Reduction and Metabolic Regulation

by | Aug 15, 2022 | Research

AOD9604 peptide is a synthetic version of human growth hormone (HGH), a revised version of hGH fragment 176-191 with a disulfide bridge. Despite the peptide’s primary role in fat reduction (lipolysis), scientific evidence suggests that it is vital in heart disease, hypercholesterolemia (the metabolic syndrome), osteoarthritis, and cartilage restoration.

While inhibiting lipogenesis, AOD9604 stimulates and improves lipolysis (fat disintegration or breakdown). The peptide does not affect IGF-1 or insulin levels and cannot be used to predict diabetes or glucose intolerance.

The Medical Benefits and Functions of AOD9604

How AOD9604 Impacts Fat Burning

  • AOD9604 is administered into the body via injection in this case. The peptide stimulates the pituitary gland by acting directly on it. This appears to be the same mechanism of action as GH, as it mimics the actions of the natural growth hormone on body fat metabolism. AOD9604 accelerates the body’s fat-burning process and restores anabolism by acting on the pituitary gland.
  • Catabolic effects reduce.
  • Induces fat release from obese fat cells.
  • It inhibits the growth of new fat around fat cells, allowing the body to lose significant weight.
  • AOD9604 does not affect appetite or blood sugar levels.

The Role of AOD 9604 in Obese Individuals

  • AOD9604 is a synthetic analog of HGH for fat loss. However, in Australia, three hundred obese people were tested in phase 2b clinical trials. Inference proved that the peptide-initiated weight loss three times faster than the placebo after 12 weeks of administration, and the weight loss rate remained consistent throughout the trial. It was discovered that peptide resistance is unlikely, and that long-term administration would cause weight loss.
  • AOD 9604 research in mice demonstrates that the peptide affects more than just the beta-3-adrenergic receptors on white fat. Initially, it was assumed that AOD9604 increased the metabolic rate in fat cells by binding to these receptors and switching them from storage to user mode. However, even mice lacking these receptors lost fat after being given AOD9604.
  • Because the beta-3-adrenergic receptor influences fat loss because of AOD9604, another mechanism must be at work. AOD9604 may indirectly stimulate apoptosis in white fat cells, according to this theory.

The Effect of AOD9604 on Patients with Heart Disease

  • Weight and fat loss are beneficial because they lower the risk of heart disease. AOD9604 has been shown to have effects on the heart in addition to fat loss. In contrast to its effect on obesity, the peptide affects metabolism by reducing complications. This mechanism of action is similar to that of drugs such as pioglitazone and acipimox, which are used to treat metabolic complications but not obesity. AOD9604 improves metabolic metrics while increasing fat loss via a secondary pathway independent of beta-3-adrenergic receptor activation.

How AOD9604 Impacts Joint pain and its functions

  • Scientific evidence shows that AOD9604 injections directly into arthritic joints can work in tandem with other therapies to control pain, improve quality of life, and reduce disability.
  • The peptide appears to be effective in treating the root cause of osteoarthritis and functioning as a treatment and preventative due to changes in the gross clinical exam and microscopic structure of the cartilage in the arthritic joint.
  • AOD9604 works well on its own to reduce joint dysfunction. However, when combined with other therapies, the peptide is more effective. It is unknown when or why this synergy occurs, but the peptide may reveal novel pathways for promoting cartilage growth.

The Adverse Effects of AOD 9604

At the start of the peptide dosage cycle, patients must become familiar with the potential risks and adverse effects of each other hormone-like peptide and injection, especially when combined with other supplements or drugs.

Even though AOD9604 is not as potent as HGH, there are side effects and risks associated with injection administration. Among the possible outcomes are:

  • Headaches
  • Stomach pain
  • Pain at the injection site
  • Swelling
  • Reddening

AOD9604 has few side effects in mice and has a high subcutaneous and oral bioavailability.

Nonetheless, it is always best to seek the advice of a licensed health practitioner before beginning any medication.


AOD 9604 is a fat-burning peptide that is essential in the treatment of heart disease, metabolic syndrome, hypercholesterolemia, osteoarthritis, and cartilage repair. The peptide also acts to enhance lipolysis and inhibit lipogenesis. The peptide does not affect IGF-1 or insulin levels and cannot be considered a risk factor for diabetes or glucose intolerance.

That notwithstanding, AOD9604 is a research peptide/chemical limited to scientific and academic purposes. Not for human use or consumption.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.