Pal-GHK and Promising Anti Wrinkle Research

by | Sep 19, 2022 | Research

Pal-GHK, also known as Palmitoyl Tripeptide-1 or Palmitoyl Oligopeptide, is a potent anti-wrinkles peptide. It moisturizes the skin, prevents crow’s feet, and regulates trans-epidermal water loss[1]. Pal-GHK peptide impacts skin health, collagen formation, and skin pigmentation. Currently, the peptide is under active review for its effects on increasing and activating collagen synthesis and blood vessel growth[2].

Pal-GHK is a peptide with a fatty acid end and a peptide end. The GHK-end is the peptide end (Glycine, histidine, and lysine). Meanwhile, the Pal-end is the fatty acid end (Palmitoyl). Pal-GHK peptide is a fibroblast stimulant and a minor component of the elastin protein. As a result, it can boost elastin, collagen, and other extracellular matrix protein synthesis in connective tissues, bone, and skin.


Potential Benefits and Functions of Pal-GHK

  • Palmitoyl Tripeptide-1 tricks fibroblasts into thinking elastin is dead. As a result, the body produces and multiplies fibroblasts at a rapid rate to replenish and regenerate the lost elastin. Pal-GHK peptide also reverses some skin aging effects.
  • When the GHK-end is connected to the Pal-end, the fatty acid (Palmitoyl) end of Pal-GHK acts as an intermediary. This transport complex does an excellent job of improving skin and cell penetration.
  • Pal-GHK peptide activates genes that can change and reset cells to a younger, healthier appearance and state. This can be accomplished by attaching Palmitoyl to the peptide sequence, GHK, which makes it more effective for DNA repair genes and increases the expression of the 14 genes that modulate antioxidant production. Following the genetic changes, the effects of aging are reduced, as are radicals and toxic agents that cause the development of age-related diseases.
  • Pal-GHK is a modified form of the extracellular matrix-derived peptide GHK that can permeate the stratum corneum and attain the epidermal and dermal skin layers.
  • Pal-GHK (0.5 M) increases collagen synthesis in human skin fibroblasts in vitro. It reduces collagen degradation ex vivo in patient-derived human skin samples exposed to UVA light when used at a concentration of 6 ppm.
  • Scientists combined it with the zwitterionic surfactant C12 dodecyl dimethylamine oxide to investigate the composite’s identity into aggregates, ribbons, and nanobelts.
  • Pal-GHK peptide as an internal standard helped quantify pal-KTTKS in anti-wrinkle creams using LC-MS/MS.
  • Scientists believe Pal-GHK peptide can activate age-related DNA repair and healing genes. According to new research, the peptide can influence hair regeneration.


Pal-GHK and Potential Positive Effect on Wrinkles

  • Pal-GHK can protect the skin from the effects of aging, according to scientific evidence[4]. Shagen et al report that In a study with 15 women, a cream containing palmitoyl tripeptide-1 was applied twice daily for four weeks, leading to statistically significant reductions in wrinkle length, depth and skin roughness. Another study applied both vehicle and palmitoyl tripeptide-1 to the skin of 23 healthy female volunteers for four weeks, documenting a small but statistically significant increase in skin thickness (~4%, compared to the vehicle alone)The peptide accomplishes this by increasing the production of elastin and collagen.
  • Palmitoyl Tripeptide-1 replenishes the skin’s extracellular matrix, reducing wrinkles, smoother skin, and less uneven skin. At the same time, it protects collagen from degradation caused by Ultraviolet A (UVA) rays.
  • Pal-GHK works to replenish lip fullness and moisture. Pal-GHK can work in conjunction with other peptides to reduce the appearance of wrinkles and fine lines. Furthermore, the peptide reduces photodamaged skin redness and discoloration (Melasma).
  • Pal-GHK peptide can be used solely or associated with Palmitoyl tetrapeptide – Z as a potent cosmetic anti-aging active ingredient.



Pal-GHK, is a skin-modulating peptide and a powerful antioxidant. It moisturizes the skin potentially preventing crow’s feet, and regulates trans-epidermal water loss.

The peptide is under review for stimulating and activating collagen synthesis and blood vessel growth. Pal-GHK is a highly effective fibroblast stimulant. It can boost the synthesis of elastin, collagen, and other extracellular matrix proteins in connective tissues, bone, and skin.

Despite its numerous advantages, Pal-GHK is a research peptide/chemical that is only for educational and therapeutic purposes and is not for human use or consumption.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Ferreira, M. S., Magalhães, M. C., Sousa-Lobo, J. M., & Almeida, I. F. (2020). Trending anti-aging peptides. Cosmetics, 7(4), 91.
  2. Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327-345.
  3. Park, S. I., An, G. M., Kim, M. G., Heo, S. H., & Shin, M. S. (2020). Enhancement of Skin Permeation of Anti-wrinkle Peptide GHKs Using Cell Penetrating Peptides. Korean Chemical Engineering Research, 58(1), 29-35.
  4. Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.