GHRP-6 (10mg)

GHRP-6 Peptide

GHRP-6 peptide is studied for its potential as a stimulant to release endogenously produced growth hormone (GH) from the anterior pituitary gland. In addition, it may potentially act as a ghrelin/growth hormone receptor agonist and is classified amongst the ghrelin analogs developed in recent decades. It has been suggested to deliver a positive influence on cardiac muscle cells, scar formation, memory formation, though it has been involved in research in other areas.

Specifications

Molecular Formula: C₄₆H₅₆N₁₂O₆

Molecular Weight: 873.032 g/mol

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys

GHRP-6 Research

GHRP-6 and Memory
Studies on rodent models have highlighted how GHRP-6 may help to consolidate newly created memories and transform short-term memories into long-term storage. Significant scientific observations further posit the role of ghrelin/GHRP-6 in spatial learning tasks. Growth hormone secretagogues such as ghrelin may bring about activity-induced cognitive improvements. Hence, the role of growth hormone may be possibly indirect and perhaps secondary to these peptides.

GHRP-6 and Brain Tissue
The potential of the GHRP-6 peptide in the amelioration of stroke has been studied using animal models. The timely exposure of the peptide appears to protect the brain tissue from reduced blood supply (following a stroke) and may help in recovery from memory lapses due to stroke.^[1] At a molecular level, the peptide and its analogs may prevent apoptosis of neurons of the central nervous system which might prevent genetic reprogramming and inflammation.

GHRP-6 Peptide and Parkinson’s Disease
A study conducted in 2018 highlighted the prevalence of ghrelin receptors in substantia nigra, a part of the brain considered to be affected in the course of Parkinson’s Disease.^[2] Research models genetically predisposed to the disease exhibited an apparent significant reduction in ghrelin receptors in their substantia nigra. It was observed that genetically modulated rats also exhibit Parkinson’s symptoms when an antagonist was introduced. The researchers concluded that “These findings suggest that the down-regulation of GHSRs in SNc-DA neurons induced the initial dysfunction of DA neurons, leading to extrapyramidal disorder under PD.” Scientists hypothesize that the peptide associated with receptors present in the substantia nigra may decrease neuronal apoptosis.

GHRP-6 Peptide and Cardiac Issues
The GHRP-6 peptide was suggested to inhibit free radical-mediated cytotoxicity of cardiac cells in porcine models.^[3] It may be employed in ongoing research into viable cardiac tissue damaged following a cardiac arrest. Research is preliminary in this focus.

GHRP-6 and Sexual Behavior
Studies on male rats have suggested the role of ghrelin receptors in the central nervous system in modulating sexual behavior and motivation. Increased amounts of ghrelin have been suggested to stimulate sexual impulses. Research findings in GHRP-6 and its modified counterpart (which may antagonize the ghrelin receptor) have suggested that ghrelin receptors in specific brain areas may influence sexual and reward-seeking conduct. There is also data to suggest that ghrelin may influence mood. The peptide and its analogs appear to help improve brain function associated with lifting moods, diminishing the secretion of stress hormones, and overcoming depressive behavior in murine models.^[4]

GHRP-6 and Scarring
GHRP-6 researchers hypothesize the peptide may aid in the survival of diverse cells through decreasing programmed cell death. The peptide has been associated with the CD36 receptor and may help to promote blood vessel growth, particularly in wounds. Experiments with GHRP-6 and rat models also suggest it may be effective in faster wound closure in rats. It appears to help in rapid wound healing and the formation of extracellular matrix proteins such as collagen, promoting the overall correct organization of tissue around a scar and thus reducing the appearance of scar marks. Hypertrophic scars, like keloids, are considered to occur due to improper deposition of matrix proteins. Scientists suggest that GHRP-6 may block this aberrant wound healing process.^[5]

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References