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Receptor Grade IGF-1 LR3 (1mg)
Receptor Grade IGF-1 LR3 (1mg) COA
Receptor Grade IGF-1 LR3 (1mg) LC
Receptor Grade IGF-1 LR3 (1mg) MS

Receptor Grade IGF-1 LR3 (1mg)

(27 customer reviews)

$99.00

IGF-1 LR3 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $94.05$89.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: IGF-1-LR3-1mg Category:

Description

Receptor Grade IGF-1 LR3 Peptide

Receptor Grade IGF-1 LR3 is an altered variant of insulin-like growth factor-1; the complete name of the peptide is insulin-like growth factor-1 long arginine 3. IGF-1 derivatives have played important roles in research studies on cell proliferation, cell division, and cell-to-cell communication. Despite research reporting physiological potential similar to the parent protein, Receptor Grade IGF-1 LR3 does not appear to interact with IGF binding proteins as strongly as IGF-1. Hence, it appears to stay in the bloodstream for longer durations (about 120 times longer) as compared to native IGF-1. The structural modifications in IGF-1 LR3 may have contributed to its increased half-life in the blood. The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 to arginine.[1]

Specifications

Molecular Formula: C400H625N111O115S9

Molecular Weight: 9117.60 g/mol

Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

Receptor Grade IGF-1 LR3 Research

Receptor Grade IGF-1 LR3 and Cell Division
Like IGF-1, research suggests that Receptor Grade IGF-1 LR3 may act as a stimulus for cell division and proliferation, primarily affecting connective tissues of the muscle and bone and cell division in the liver, kidney, skin, lung, nerve, and blood tissues. IGF-1 is best considered to be a maturation hormone because of its apparent influence in cell proliferation, differentiation, and maturation, helping them to carry out their specialized functions. The longer life span of Receptor Grade IGF-1 LR3 in the blood makes it a potentially potent molecule as compared to IGF-1. Receptor Grade IGF-1 LR3 appears to provide about three times as much cellular activation compared to similar IGF-1.[2] Researchers report that “The response with LR3IGF-I was particularly striking because this peptide [appears to bind] 3-fold less well than IGF-I to the type 1 IGF receptor.“ It is important to remember that IGF-1 LR3 peptide and every IGF-1 derivative have not been observed to mediate cellular enlargement (hypertrophy), and instead may participate in cell division and proliferation (hyperplasia). For instance, in the case of muscle, studies suggest Receptor Grade IGF-1 LR3 may not induce enlargement of muscle cells, rather simply increasing the total number of muscle cells.

Receptor Grade IGF-1 LR3 and Myostatin
Myostatin (also known as growth differentiation factor 8) is a muscle protein that is considered to surpress the growth and differentiation of muscle cells. Myostatin is, thus crucial in protection from unregulated hypertrophy. However, some situations demand inhibition of myosin. Blocking of myosin may be impactful in Duchenne Muscular Dystrophy (DMD) research, or in research related to muscle loss due to prolonged immobility. In such cases, blocking the natural enzyme might slow down muscle breakdown. Studies conducted in mouse models of DMD have suggested that Receptor Grade IGF-1 LR3 and other IGF-1 derivatives may overcome the adverse impacts of Myostatin to protect muscle cells and prevent apoptosis.[3] The scientists note that “results together suggest that myostatin suppresses both basal and IGF-1-stimulated proliferation of both WAT and BAT preadipocytes, actions that are again similar to those in muscle satellite cells”. Receptor Grade IGF-1 LR3, due to its proposed stability, may potentially counteract Myostatin by activating MyoD, a muscle protein normally triggered through prolonged physical strain.

Receptor Grade IGF-1 LR3 and Metabolism, Diabetes
Researchers suggest that Receptor Grade IGF-1 LR3 may indirectly boost fat cell dissolution through association with the IGF-1R receptor and the insulin receptor. These interactions may improve glucose uptake from the blood by muscle, nerve, and liver cells. This potential may result in an overall reduction in blood sugar levels, which then trigger adipose tissue as well as the liver to initiate catabolism of glycogen and triglycerides. Overall, this may lead to a decrease in adipose tissue and net energy consumption (i.e. net catabolism). Given its potential in controlling blood sugar levels, Receptor Grade IGF-1 LR3 may reduce insulin levels and the need for exogenous insulin in diabetes.[4]

Receptor Grade IGF-1 LR3 and Longevity Research
Studies observe that Receptor Grade IGF-1 LR3 may promote tissue repair and cell survival, making it a potentially protective molecule against cellular damage. Research in cows and pigs indicate that Receptor Grade IGF-1 LR3 exposure may possibly overcome the impacts related to cell turnover. Ongoing research in mice has focused on the potential of Receptor Grade IGF-1 LR3 in possibly mitigating the progression of a wide range of conditions such as muscle atrophy, dementia, and kidney disease.[5]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxid Med Cell Longev. 2017;2017:3035184. doi: 10.1155/2017/3035184. Epub 2017 Dec 20. PMID: 29422987; PMCID: PMC5750484.
  2. Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J. 1992 Feb 15;282 ( Pt 1)(Pt 1):91-7. doi: 10.1042/bj2820091. PMID: 1371669; PMCID: PMC1130894.
  3. Li N, Yang Q, Walker RG, Thompson TB, Du M, Rodgers BD. Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis. Endocrinology. 2016 Jan;157(1):282-91. doi: 10.1210/en.2015-1546. Epub 2015 Nov 18. PMID: 26580671; PMCID: PMC4701895.
  4. Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021 Feb 4;11(2):217. doi: 10.3390/biom11020217. PMID: 33557137; PMCID: PMC7913862.
  5. AsghariHanjani N, Vafa M. The role of IGF-1 in obesity, cardiovascular disease, and cancer. Med J Islam Repub Iran. 2019 Jun 17;33:56. doi: 10.34171/mjiri.33.56. PMID: 31456980; PMCID: PMC6708115.
  6. Philippou A, Barton ER. Optimizing IGF-I for skeletal muscle therapeutics. Growth Horm IGF Res. 2014 Oct;24(5):157-63. doi: 10.1016/j.ghir.2014.06.003. Epub 2014 Jun 19. PMID: 25002025; PMCID: PMC4665094.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

27 reviews for Receptor Grade IGF-1 LR3 (1mg)

  1. Emma Martin –

    Very qualitative products

  2. Scarlett Rivera –

    Always satisfied with the products, service and shopping platform

  3. Elliot Duffy –

    Quality products and fast delivery. Can’t really ask for more

  4. A. Jimenez –

    Fast and accurate service with the best and very competitive prices.

  5. Lydia Sullivan –

    Would love it if you guys advertised more deals or sales!

  6. Rolf Steiner –

    Fast delivery, excellent product

  7. Larry Ray Reed –

    Your packaging is neat and gets the job done. Peptides came in safe and sound.

  8. Aki Kadomatsu –

    They take a lot of my companies peptide budget!

  9. Sonia Pierce –

    I wish I knew about peptides earlier. I’m relatively new to this area of research, but it has held up my interest tremendously and I thank BP for always making themselves available to answer my questions and teach me all I need to know

  10. Kat Creedon –

    They sometimes take a while to respond to emails, but always do eventually. Aside from that, no criticism whatsoever

  11. Sarah Yan –

    This product gives great feedback in my experiments. Also great shipping times, was worried that the shipping would take longer or they would take longer to ship the products out but does not seem like it.

  12. Mai Yang –

    Have always had a good experience with them. Peptides are consistently top quality and I do notice a change in my research results.

  13. Emmit Coddy –

    Was browsing their page and saw they had a pretty good easter promotion! Love myself a deal.

  14. Will Jacobs –

    Amazing

  15. Andy Vale –

    Customer service is as good as I have been hearing. I had an issue with my order. It seems like they missed a peptide order and sent me double of one of the others. I emailed them but decided it might be a good time to see if I can get a hold of them via telephone. Low and be hold I got in contact with someone right away. I explained to them that i got my order and everything is in. good condition but that they sent me double of one order and forgot about the other completely. I waited on hold for maybe 2 minutes and they came back informing me that they just placed a free order now to be sent over night. Told me to keep the extra that they sent over as well. After we hung up I was surprised to see that they even sent a discount code for my next order.

  16. Alisa Rodrigez –

    Ofrecen tantos códigos de descuento y realmente ayuda con un pedido grande. Gracias BP

  17. Annie Haas –

    They have blog posts describing every item they now sell. Love this as a quick way of brushing up my information on peptides I don’t know much about.

  18. denny wolfe –

    Fantastic business. Vials were all in good condition and looked like their pictures.

  19. Felix Peters –

    Great things have happened to me throughout my time working with Biotech. First time I’ve ordered anything from them. Yes, I think they’d benefit from a new package design.

  20. Richard Dail –

    My stuff arrived to me in a damaged state! Contacted them and got on the line with Jamie. They were able to handle the situation and had a new batch of peptides ready to be shipped out for me. I couldn’t be happier with both the peptides and the service.

  21. Jen Mones –

    I’ve never seen anything run out of stock, and even if it did, it was refilled in no more than two days at most. There’s hardly a lengthy wait for anything here.

  22. Aaron Alrich –

    1000/10 for this company.

  23. Bran Schmitz –

    They have so many peptides that you don’t even have to visit multiple sites for all you need. You can buy it all from here.

  24. Kay Watts –

    Research is better since using BP

  25. Vee Fragoso –

    Was looking for a new peptide site and found you guys. Ecstatic about the prices! Most places are costing way too much now and you guys are one of the only few places that have reasonable prices.

  26. Travis Wayne –

    I will not buy from any other company, Biotech has all my necessary peptide here and they get them out faster than any peptide company I have used in the past.

  27. Andre Callender –

    Amazing restock schedule. Never saw them out of stock for products I needed

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