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Ipamorelin (5mg)
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Ipamorelin (5mg)

(29 customer reviews)

$46.00

Ipamorelin peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $43.70$41.40
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Ipamorelin-5mg Category:

Description

Ipamorelin Peptide

Ipamorelin is a small pentapeptide that binds to the receptor of ghrelin/growth hormone (GH) secretagogue, and research has suggested the peptide to be selective in its mode of action.[1] Ipamorelin, researchers report, does not appear to induce non-specific release of hormones like prolactin, thyroid-stimulating hormone, ACTH, luteinizing hormone, follicle-stimulating hormone, or cortisol. The high specificity of the peptide makes it an ideal model for the study of selectivity in receptor binding. It appears to function through interaction with cognate receptors on the target cell surface and mediates a cellular response. Ipamorelin may induce secretions from the pituitary gland, promoting growth in animal study models.[2] In addition, it may not only trigger the expression of insulin-like growth factor-1(IGF-1) but may also inhibit the secretion of somatostatin.

Specifications

Molecular Formula: C38H49N9O5

Molecular Weight: 711.85 g/mol

Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2

Ipamorelin Research

Ipamorelin and Bone
Lessened bone density over prolonged periods may lead to fracture. Ipamorelin studies in rats have observed that the peptide may prevent bone loss following prolonged glucocorticoid exposure, and also may induce up to a four-fold increase in bone formation.[3] The researchers also reported that “the decrease in muscle strength and bone formation found in GC-rats was counteracted by simultaneous administration of the growth hormone secretagogue.” The peptide may potentially improve the bone mineral density of both existing and new bones. Additionally, it may possibly mitigate or reverse ancillary impacts such as muscle wasting and fat deposition in visceral organs.

Ipamorelin and Diabetes
Studies in murine models of diabetes have suggested an efficacy of Ipamorelin in promoting insulin release from islet cells of the pancreas.[4] Studies suggest that the peptide may mediate the release of insulin through the indirect excitation of calcium channels found on the islet cells. The hypothesized mechanism of Ipamorelin action highlights the limitations of type 2 diabetes and further study may be of interest to researchers.

Ipamorelin and Corticosteroids
Glucocorticoids are the kind of corticosteroids that are commonly considered to exert an anti-inflammatory response in diverse conditions ranging from cancer to autoimmune disease. Ancillary action has also been reported. Over long durations, a higher concentrations of hormones may be required to overcome physiological ancillary impacts. Researchers studying the action of Ipamorelin have suggested the peptide’s potential to decrease certain unintended impacts associated with glucocorticoid exposure.

Ipamorelin and Muscle Cells
Growth hormone (GH) and GH secretagogues such as Ipamorelin may decrease any catabolic action of glucocorticoids on muscle cells. Studies on Ipamorelin posit that it may help to reestablish the nitrogen balance and reduce nitrogen wasting in the liver of rats that were exposed to glucocorticoids. The molecule exhibited the potential to overcome muscle wasting and loss of bone density in research models exposed glucocorticoids.

Ipamorelin as Ghrelin Receptor Probe
The peptide appears to bind strongly to the ghrelin receptor and may act as a selective agonist. Interestingly, the ghrelin receptor has been observed to increase cardiac failure and certain types of cancer, including carcinomas. Researchers have proposed studying Ipamorelin as a probe in positron emission tomography (PET) scans to help diagnose research models. [5] Further research is ongoing.

Ipamorelin and Post-Operative Ileus
Post-operative Ileus (POI) is a condition characterized by an inability of the subject to accept oral nutrition as the GI system stops functioning. Ipamorelin has been studied in multiple proof-of-concept studies to determine its potential to reduce POI. It was found to shorten the time of uptake of the first meal by about 12 hours in POI models.[6] The researchers concluded that “ipamorelin accelerates gastric emptying in a rodent model of postoperative ileus through the stimulation of gastric contractility by activating a ghrelin receptor-mediated mechanism involving cholinergic excitatory neurons.”  Some of the research observations in this and other studies suggest that residual radiolabeled food remaining in the stomach of rats with POI was less after the influence of Ipamorelin, even when compared to rats without POI.

Additionally researchers noted that when exposed to Ipamorelin, the geometric location of the food was observed to be similar for both rats without POI and those with POI. Furthermore, the radiolabeled food was located more distally in the GI tract and is similar to rats without POI, after Ipamorelin was given to rat models of POI.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
  2. Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999 Apr;9(2):106-13. doi: 10.1054/ghir.1999.9998. PMID: 10373343.
  3. Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001 Oct;11(5):266-72. doi: 10.1054/ghir.2001.0239. PMID: 11735244.
  4. Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
  5. Childs MD, Luyt LG. A Decade’s Progress in the Development of Molecular Imaging Agents Targeting the Growth Hormone Secretagogue Receptor. Mol Imaging. 2020 Jan-Dec;19:1536012120952623. doi: 10.1177/1536012120952623. PMID: 33104445; PMCID: PMC8865914.
  6. Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
  7. Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004. Epub 2017 Apr 8. PMID: 28400207; PMCID: PMC5632578.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

29 reviews for Ipamorelin (5mg)

  1. Isla Phillips –

    All is very easy and fast, could not ask for better

  2. Ethan Cooper –

    Excellent packaging

  3. Everly Ryan –

    I accidentally ordeed the wrong item. Thanks for reshipping for free!

  4. Bailey Maguire –

    So far so good. Never had any issues buying here. I really appreciate the ease of this website and the smooth transaction. Was not too hard to get around and had your standard check out method. Got to use a discount code they sent me not too long ago as well. It’s estimated i’ll get my peptide within 2 days of my order too.

  5. Tamara Qonita Mahadi –

    Thanks for the fast service and great peptides!

  6. Shannon Porter –

    This is a solid company. Honestly I didn’t expect it at first, but I got convinced me with every order

  7. Patrick Pan –

    So far I am very impressed by the quality of these products

  8. Samantha Singh –

    Wish I would see more lifestyle articles on your blog and how peptides can improve it

  9. Paul Allen –

    Danny from CS is a gem. Give that one a raise

  10. Bruno Garcia –

    Very knit-picky person here- Could not find a flaw, that is how good they are

  11. Mia Jakh –

    Top tier peptides!

  12. Koleen Farrugia –

    purest products i’ve found

  13. Jacob Reily –

    Other than the A+ quality products and service, I come back becasue of their constant promos or sales to be honest.

  14. Andy Khalaf –

    Excellent peptides, One of the best I have used in the last few years. Did not effect the outcome of my research too much but that typically would take a while to show.

  15. Karmen Wheeler –

    Everything came packaged safley. I only wish the box was different as I had a hard time figuring out what it was I had just received. Side note, everything came faster than expected.

  16. jose lopez –

    Articles are informative and are a pretty reliable source.

  17. J. Begg JR. –

    Great site with excellent customer service and open lines of contact. Definitely worth the money!!. My search for certain items was aided by an employee who patiently explained the differences between each item I came across.

  18. Anni Summers –

    A joy to work with, Danny is always there for me when I need a little assistance tweaking anything.

  19. Maggie cortez –

    Estoy muy impresionada. Compraré de nuevo y lo recomendaré a mis amigos.

  20. Andy Laffon –

    For the last year, I’ve been purchasing from them and have been very satisfied. Danni is the person I call when I need help with an order or if I need to make any changes.

  21. Chirag Patel –

    Hands down the best company I have ever bought from

  22. Mason Hosek –

    Very quick and controlled results from this product. Its quality is very clear in how it manifests itself in research and long-term storage.

  23. Greg Davis –

    Will surely buy again

  24. Amir Cibik –

    Amazing

  25. Andy Nakajima –

    I turned into a repeat customer for sure

  26. Vincient Thomas –

    Taylor is extremely helpful and goes above and beyond to help you out and solve any issue you’re having. Very happy to have worked with them. My peptides had issues with customs and thus I was not going to get them on time. I was on a tight schedule and dealing with companies like this can be a headache. It was nice to deal with Taylor who actually helped and did whatever they could to help me out as well and not leave me hanging dry. We ended up canceling and replacing the order but up until then they did everything they could to help get ahold of the shipping company and get this sorted.

  27. Lee Wong –

    Happy with the service and Peptides. Been looking for a good peptide supplier for a while now and I feel like I found the place for me. Nicely priced as well!

  28. Tom King –

    Ipamorelin is one of the most underrated peptides and I am glad I gave it a chance for my research.

  29. ANTONIOS CHATZISAVVAS –

    Very fast shipping to Greece.I will update once i will receive the purity results from the lab.

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