Obesity is simply the result of excessive fat accumulation caused by eating too many bad fats or carbohydrates. Although carbohydrates are necessary for primary metabolism, muscle growth, contraction, and brain function, too much can cause insulin to overflow the pancreas. The body immediately goes into fat storage mode, resulting in obesity or being considered overweight.
Obesity harms one’s health because it can cause inflammation and metabolic syndrome. As a result, fat accumulation increases while growth hormone signaling is suppressed. Low GH levels affect many metabolic functions, including aging, and threaten muscle strength, heart health, bone density, the DNA system, and cognitive capacity. Extreme conditions can result in death.
These events have prompted scientists and researchers to devote more time and effort to discover the best treatment for obesity and overweight. And over the years, exercise and diet have been the most used methods for treating obesity, which has now been proven ineffective in some people because each body processes food differently. This article will talk about the best peptides to lose weight.
Which Are The Best Peptides To Lose Weight?
AICAR: AICAR is a short peptide with insulin-regulating properties and might be one of the best peptides to lose weight. It is also known as 5-aminoimidazole-4-carboxamide ribonucleoside. According to research, the peptide is essential for myocyte function and can reduce adipose tissue inflammation and insulin resistance. AICAR also increases the number of GLUT-4 receptors in muscle tissues, and long-term administration is required for exercise. These actions, in general, help reduce obesity and overweight and promote significant weight loss.
Adipotide: As the name suggests, Adipotide is a fat dissolving peptide that induces fat loss by inducing apoptosis in fat cells. This is accomplished by limiting blood supply to adipose (fat) tissues. Furthermore, regarding weight loss, Adipotide reduces the frequency and quantity of food consumed by influencing appetite.
Epithalon: Epithalon plays an essential role in sleep regulation by restoring circadian rhythm balance. It is worth noting that there is a strong relationship between sleep and overall body composition. As a result, by influencing rest, the peptide indirectly improves body composition. Research shows that Growth hormone production peaks during specific stages of sleep. In this context, Epithalon increases GH release and thus reduces obesity by improving sleep efficiency. The delta Sleep-Inducing Peptide (DSIP) has similar effects to Epithalon and can help to reduce obesity tendencies.
AOD 9604: AOD-9604 is a human growth hormone variant that has been altered and is among the best peptides for weight loss. According to research, it increases fat metabolism and lowers insulin levels in mouse models. According to this study, the efficacy of AOD-9604 in inducing weight loss is three times that of placebo.
The Analogs of the Growth Hormone-releasing Hormone: Fragment 176-191, GRF, Modified-GRF, Sermorelin, CJC-1295, and Tesamorelin are analogues of growth hormone-releasing hormones that significantly increase GH levels, promote bone strength, induce fat disintegration, and muscle growth. It’s worth noting that Tesamorelin is the only human-approved growth hormone-releasing hormone peptide analog. In studies, Tesamorelin has been shown to reduce adiposity by 20% or more in its target population. Furthermore, this study demonstrates that it is far more effective than all other anti-adiposity therapies combined.
MOTS-c: Energy balance and obesity are inextricably linked. MOTS-c indirectly causes weight loss by improving energy balance. MOTS-c enhances the body’s consumption of raw materials at the mitochondrial level. MOTS-c increases exercise capacity while decreasing metabolic stress. All of these are necessary for the start of weight loss.
Melanotan 1 and Melanotan 2: Although these peptides primarily increase sexual arousal, research has shown that they can also positively regulate energy balance. Melanotan peptides work through the melanocortin system to simultaneously boost and decrease energy expenditure and intake. As a result, Melanotan administration downregulates calorie intake to about 400 kcal/day.
Semaglutide: Semaglutide is a GLP-1 analog that lowers blood sugar levels by increasing insulin secretion. The peptides influence and delay gastric emptying and decrease intestinal motility, resulting in reduced appetite, increased fullness, and a slight increase in blood sugar levels. This Semaglutide action indirectly induces weight loss and lowers obesity prevalence.
Finally, the peptides mentioned above both directly and indirectly cause weight loss via various mechanisms of action. Although most of these peptides are being researched, some are being tested in clinical trials to determine their properties.
Biochemical processes play critical roles in weight loss, demonstrating that diet and exercise alone will not suffice. However, studies show that other methods, such as peptides, can be used to activate these biochemical changes. The above peptides are some of the best peptides to lose weight.
While exercise and diet are essential for healthy living and weight management, scientists are looking into alternative ways to directly induce weight loss by influencing the biochemical process in the human system.
Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.