Enhancing Muscle Growth with the Help of Peptides

by | Nov 30, 2022 | Research

Over the years, public demand has motivated organizations and their researchers to develop new and more effective ways for individuals to quickly gain lean muscle, lose significant body weight, and be generally fit. Proper diet and regular exercise remain at the top of the list for almost all these goals. However, numerous factors can limit muscle growth and overall body composition.

Researchers have discovered the use of peptides to achieve most of these goals. Studies are still underway, but peptides promise to be the solution of the future for building the body, burning fat, enhancing lean muscle, and promoting muscle gain.


What are the best peptides for muscle growth?

Growth hormone secretagogues are targeted as the best peptides for muscle growth because they can activate the synthesis and release of Human Growth Hormone (HGH)[1]. HGH is essential for indirectly increasing muscle gain and decreasing body fat.

The secretagogues of growth hormones cause significant changes in body composition, recovery, muscle gain, and exercise performance. As a result, the following peptides are regarded as the best for muscle growth due to their HGH compositions:

Follistatin-344: Follistatin is a synthetic version of a naturally occurring body protein. The TGF-1 family protein known as myostatin is a naturally occurring substance that prevents new muscle gain. Research shows that Follistatin is an effective myostatin inhibitor, one factor that makes it the best peptide for muscle growth[2].

Follistatin also promotes muscle gain by increasing the number and mass of muscle fibers, and it does so without the need for other muscle-building factors such as diet, exercise, etc. Follistatin’s ability to increase muscle growth and strength is proving to be an effective method for treating muscular dystrophy. When administered intradermally, Follistatin also has anti-inflammatory effects in muscular dystrophies like Duchenne Muscular Dystrophy. Follistatin is one of the best peptides for muscle growth because of its unique functions.

ACE-031: This protein inactivates myostatin by binding to type IIB activism receptor (ACVR2B) and immunoglobulin G1-Fc (IgG1-Fc). This action is critical in treating neuromuscular and muscle-wasting disorders such as Duchenne Muscular Dystrophy, which results in significant hair growth. Furthermore, the peptide protects muscles from metabolic damage and promotes the vascularization of muscle tissues[3]. The peptide accomplishes this by inhibiting myostatin-regulatory growth, oxidative damage, and fatigue onset.

ACE-031 is one of the best peptides for muscle growth because it inhibits myostatin for hair growth and promotes oxidative respiration, improving muscle thermodynamics. This peptide boosts muscle function, increases lean body mass, and lowers fat accumulation.

Mechano-Growth Factor (MGF): Mechano-growth Factor is an IGF-1 isoform important in muscle remodeling, cellular proliferation, and survival. MGF accelerates muscle cell healing by regulating macrophages. MGF, according to studies, causes hypertrophy and muscle repair by activating muscle stem cells known as satellite cells.

Scientists believe that MGF can improve muscle health in degenerative diseases and increase lean body mass by enhancing the benefits of exercise in muscles[4]. This finding indicates a lower prevalence of obesity and other health risks. 

IGF-1 LR3: It is derived from the insulin-like growth factor 1 (IGF-1) protein, which is required for cell division, proliferation, and cell-to-cell communication. In mouse models of Duchenne Muscular Dystrophy, research shows that IGF-1 LR3 and other IGF-1 derivatives play a critical role in mitigating the side effects of myostatin, thereby protecting muscle cells and reducing apoptosis[5].

IGF-1 LR3’s efficacy on myostatin is due to its stability, and it acts to stimulate MyoD—a muscle protein activated during exercise or tissue damage, inducing hypertrophy.

GHRP-2: Growth Hormone Releasing Peptide (GHRP-2) is a portion of the growth hormone secretagogue/growth hormone secretagogue receptor, also known as Pralmorelin. GHRP-2 is among the best peptides for muscle growth because it promotes muscle gain via two mechanisms: increasing protein synthesis and accumulation and decreasing protein degradation.

According to studies, GHRP-2 reduces muscle atrophy by repressing the atrogin-1 and MuRF1 proteins, which regulate muscle degradation pathways. Furthermore, the peptide promotes muscle protein synthesis by stimulating growth hormone and insulin-like growth factor-1[6]. Because of the combined effect of decreased protein disintegration and increased synthesis, GHRP-2 is one of the best peptides for muscle growth.

Finally, the growth hormone secretagogue (GHS) peptides are thought to be the best for muscle gain because they actively stimulate the human growth hormone, resulting in muscle growth and fat loss. The list of effective peptides for muscle growth is long. Researchers are constantly integrating and running clinical trials to determine the best peptides for muscle growth with no side effects or other health-harming effects.



  1. Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual medicine reviews, 6(1), 45–53. https://doi.org/10.1016/j.sxmr.2017.02.004
  2. Haidet, A. M., Rizo, L., Handy, C., Umapathi, P., Eagle, A., Shilling, C., Boue, D., Martin, P. T., Sahenk, Z., Mendell, J. R., & Kaspar, B. K. (2008). Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4318–4322. https://doi.org/10.1073/pnas.0709144105
  3. Attie, K. M., Borgstein, N. G., Yang, Y., Condon, C. H., Wilson, D. M., Pearsall, A. E., Kumar, R., Willins, D. A., Seehra, J. S., & Sherman, M. L. (2013). A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle & nerve, 47(3), 416–423. https://doi.org/10.1002/mus.23539
  4. Matheny, R. W., Jr, Nindl, B. C., & Adamo, M. L. (2010). Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology, 151(3), 865–875. https://doi.org/10.1210/en.2009-1217
  5. Lozier, N. R., Kopchick, J. J., & de Lacalle, S. (2018). Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength. Frontiers in physiology, 9, 1418. https://doi.org/10.3389/fphys.2018.01418
  6. Hu, R., Wang, Z., Peng, Q., Zou, H., Wang, H., Yu, X., Jing, X., Wang, Y., Cao, B., Bao, S., Zhang, W., Zhao, S., Ji, H., Kong, X., & Niu, Q. (2016). Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation. PloS one, 11(2), e0149461. https://doi.org/10.1371/journal.pone.0149461

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