Peptides Used to Promote Healthy Skin

by | Dec 1, 2022 | Research

The skin is the largest organ in the human body and performs numerous essential functions, but it is also vulnerable to various skin-harming infections and diseases. The skin is a barrier against thermal, physical, and mechanical injury and obstructive substances. It helps retain moisture and provides a sensory organ for temperature and touch. Furthermore, the skin acts as a temperature regulator, an immunization organ that detects diseases, and produces Vitamin D. The functions our skin provides go on and on.

Over time, cosmetic industries have sought various means to improve the robustness of skin functions. As scientists and researchers have studied peptide effects on skin health, substantial progress has been made. One of the goals of peptide discovery is to amass the ability to improve facial glow, elasticity, firmness, and smoothness of the complexion without invasive or expensive medical treatments.

These peptides act through various mechanisms, including carrier, signaling, neurotransmitter inhibition, and enzyme inhibition. These action mechanisms work together to increase collagen secretion and decrease disintegration.


The best peptides for skin and improving its functions

Aging is a significant threat to the skin resulting from declining collagen production as the body ages[1]. Following this effect, the skin is exposed to various infections and diseases, which can cause grievous harm to the extremities. According to research, the following peptides are the best for the skin and have few or no side effects.

Syn-AKE (Topical): It is one of the best peptides for skin and is also known as dipeptide di-amino-butyryl benzyl amide di-acetate or tripeptide-3. Syn-AKE is the synthetic equivalent of Waglerin-1 peptide, a Temple Viper Venom derivative. According to studies, Syn-AKE can reduce the frequency of muscle motility and cellular mobility, resulting in smoother skin[2]. Syn-AKE is a potent acetylcholine antagonist. The peptide has anti-aging effects by preventing acetylcholine from binding to its receptors. It reduces wrinkle prevalence and fine lines, relaxes facial muscles, and smoothens the skin covering the muscles. It is worth noting that the peptide works similarly to Botox, preventing wrinkles and comparatively improving skin firmness and elasticity.

Melanotan 1 (MT-1): Melanotan 1 is a peptide derived from the alpha-melanocyte-stimulating hormone. The peptide effectively treats patients with erythropoietic protoporphyrin, preventing phototoxicity and other sun-induced skin damage. According to research, Melanotan 1 is the best peptide for the skin because it is used for tanning it under high UV exposure, protecting it from damage and potential melanomas[3].

Thymosin Alpha-1: Thymosin Alpha-1 is a peptide derivative of thymus gland tissue that is considered the best peptide for the skin due to its potent immune function influencer[4]. The peptide also has unwavering antifungal properties.

Dendritic cells can be found in almost every body organ, including the skin. By increasing the production and maturation of dendritic cells, the peptide protects against fungal attacks and infections. In cases of fungal attacks or disease on the skin, the cells stimulate T-helper cells, improving skin health.

GHK-Cu: GHK-Cu is a copper peptide found in saliva, urine, and plasma, with anti-aging and wound-healing properties. The peptide also helps to prevent bacterial infections, inhibit free radicals, stimulate collagen synthesis, and improve skin and fibroblast health.

GHK-Cu is an effective skin health peptide because it promotes dermal regeneration by increasing collagen production, which includes the breakdown of collagen, extracellular matrix, and glycosaminoglycan components[5]. The peptide accomplishes this by attracting endothelial cells, immune cells, and fibroblasts. Cosmetic companies use this peptide in skincare products because it improves skin elasticity, firmness, and tightening. It shields the skin from UV rays, reduces wrinkles and fine lines, and reduces hyperpigmentation.

Furthermore, the peptide reduces scar formation, smooths rough skin, prevents hypertrophic healing, and repairs the structure of aged skin. GHK-Cu also promotes angiogenesis and accelerates wound healing at injury sites. Notably, the peptide induces angiogenesis via its cauterization effect in skin burn conditions.

Argireline: Argireline is a SNAP-25 fragment derivative. Due to its anti-wrinkling and anti-aging properties, it is a valuable peptide for skin enhancement[6]. Argireline decreases muscle motility, reducing wrinkles and fine lines caused by aging and facial expressions. The peptide also increases collagen production. Argireline improves skin elasticity, moisture retention, smoothness, and texture by increasing collagen production.

Finally, the best peptides for the skin are not limited to the ones mentioned above; the list goes on. Promoting skin health is critical, which has prompted scientists to research peptides that benefit the skin with no side effects. However, research is ongoing into how these peptides can improve skin health and function.



  1. Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006). Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. The American journal of pathology, 168(6), 1861–1868.
  2. Errante, F., Ledwoń, P., Latajka, R., Rovero, P., & Papini, A. M. (2020). Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Frontiers in chemistry, 8, 572923.
  3. Dorr, R. T., Ertl, G., Levine, N., Brooks, C., Bangert, J. L., Powell, M. B., Humphrey, S., & Alberts, D. S. (2004). Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers. Archives of dermatology, 140(7), 827–835.
  4. Mandaliti, W., Nepravishta, R., Pica, F., Vallebona, P. S., Garaci, E., & Paci, M. (2017). Thymosin α1 Interacts with Hyaluronic Acid Electrostatically by Its Terminal Sequence LKEKK. Molecules (Basel, Switzerland), 22(11), 1843.
  5. Pickart, L., & Margolina, A. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International journal of molecular sciences, 19(7), 1987.
  6. Wang, Y., Wang, M., Xiao, S., Pan, P., Li, P., & Huo, J. (2013). The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. American journal of clinical dermatology, 14(2), 147–153.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.