The Best Peptides for Hair Growth

by | Dec 3, 2022 | Research

Hair loss can occur in men and women, but men experience it more frequently[1]. Alopecia is the medical term for hair loss and has degrees of severity. Hair loss on the scalp and body can either be temporary or permanent. Androgenic Alopecia is hair loss caused by genetics; it worsens with age and can result in baldness.

Other causes of hair loss may be medical conditions, hormonal changes, and medications and supplements used to treat cancer, depression, heart problems, arthritis, etc. Furthermore, hair loss can be caused by stress, head radiation therapy, certain hairstyles, and treatments. However, age, diabetes, lupus, and poor nutrition are all significant risk factors for hair loss. Hair loss is widespread in all ages and can affect children and the elderly.

Scientists used treatments now shown to be ineffective in stopping hair loss and stimulating growth. However, research is developing to show that peptides suitable for hair growth exist. They are making it possible to gain access to adequate and simple supplementary treatments for hair loss.

 

The best peptides for the prevention of hair loss and substantial hair growth

There are many peptides used to prevent hair loss and stimulate growth. However, research shows that the following are the best peptides for hair growth:

AHK-Cu: AHK-Cu is a tripeptide that contains copper. It is found in mammalian blood and is essential for growth regulation, death, and vascular endothelial cells. According to research, AHK-Cu is effective for the prevention and enhancement of hair loss and hair growth[2]. This is accomplished by increasing the levels of vascular endothelial growth factor and endothelial cells, which promotes nutrient supply to hair follicles.

AHK-Cu stimulates blood vessel growth, which keeps the hair healthy, long, and firm. Furthermore, AHK-Cu prevents hair loss by slowing the transforming growth factor beta’s activities, reducing dihydrotestosterone’s effect on hair loss. AHK-Cu prevents hair loss while protecting hair follicles from negative stress by downregulating the effects of dihydropteroate. Furthermore, AHK-Cu increases hair thickness and size while also extending hair lifespan. Because of its products and functions, AHK-Cu is regarded as one of the best peptides for hair.

PTD-DBM: The Protein Transduction Domain-fused Disheveled Binding Motif (PTD-DBM) prevents hair loss and promotes growth. PTD-DBM prevents hair loss by interfering with CXXC5 and Dvl protein-protein interactions, extending the anagen phase of hair follicles[3]. This effect encourages hair growth, strength, and health while preventing hair loss.

PTD-DBM stimulates Wnt/-catenin signaling, which increases hair follicle cellular proliferation, promoting the formation of new hair follicles and the growth of existing follicles.

GHRP-2: Growth Hormone Releasing Peptide (GHRP-2), or Pralmorelin, is a growth hormone secretagogue/growth hormone secretagogue receptor. GHRP-2 can stimulate the pituitary gland’s release of human growth hormone.

Following the ineffectiveness of DHT-blockers, one of the leading causes of hair loss is a lack or low level of Insulin-like growth factor 1 (IGF-1). GHRP-2, on the other hand, is regarded as the best hair peptide because it prevents hair loss and promotes hair growth by positively modulating insulin-like growth factor 1. (IGF-1).

Thymosin Beta-4 (TB-500): Thymosin Beta-4, which thrives in human and animal cells, is synthesized as TB-500. TB-500 increases angiogenesis and the growth of new blood cells from pre-existing vessels by four to six folds. In addition, the peptide attracts endothelial cells and produces enzymes required for extracellular matrix degradation.

Initial research has shown that TB-500 promotes hair growth by influencing the active phases of the hair follicle cycle, such as stem cell migration and their progeny to the follicle’s base, extracellular matrix remodeling, and differentiation[4]. The peptide also increases the duration of hair growth in the anagen phase. Furthermore, TB-500 is the best peptide for hair because it promotes hair regrowth and accelerates hair growth.

BPC-157: Body protection compound (BPC)-157 is a fragment of the parent protein, body protection compound (BPC), extracted and purified from gastric juice. BPC-157 is regarded as one of the best peptides for hair because it stimulates the production of extracellular matrix proteins such as collagen by increasing fibroblast recruitment[5].

Furthermore, BPC-157 promotes vascular growth by activating the VEGFR2 pathway and accelerating endothelial cell growth and proliferation. These are necessary for hair follicle growth, multiplication, and longevity, thereby preventing hair loss and improving hair density and overall health.

CJC-1295 DAC: CJC-1295 with added DAC is a synthetic fragment of growth hormone-releasing hormone that increases plasma levels of insulin-like growth factor-1 and growth hormone. CJC-1295 DAC is one of the best hair peptides because it promotes hair growth, prevents hair loss, and maintains hair density and color. This is accomplished by actively regulating physiological levels of growth hormone while increasing production. It also indirectly stimulates the production of hormones such as insulin-like growth factor 1 (IGF-1), which is required for active hair growth[6].

 

Conclusion

The peptides listed above are thought to be the best for hair growth because of their ability to stop hair loss, encourage hair growth, and improve overall hair health. These peptides, however, are just a few from a long list of valuable peptides for hair growth. Scientists are still looking into the various mechanisms of action these peptides can use to impact hair growth positively.

 

References


  1. Ho CH, Sood T, Zito PM. Androgenetic Alopecia. [Updated 2022 Aug 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430924/
  2. Pyo, H. K., Yoo, H. G., Won, C. H., Lee, S. H., Kang, Y. J., Eun, H. C., Cho, K. H., & Kim, K. H. (2007). The effect of tripeptide-copper complex on human hair growth in vitro. Archives of pharmacal research, 30(7), 834–839. https://doi.org/10.1007/BF02978833
  3. Lee, S. H., Seo, S. H., Lee, D. H., Pi, L. Q., Lee, W. S., & Choi, K. Y. (2017). Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. The Journal of investigative dermatology, 137(11), 2260–2269. https://doi.org/10.1016/j.jid.2017.04.038
  4. Cha, H. J., Philp, D., Lee, S. H., Moon, H. S., Kleinman, H. K., & Nakamura, T. (2010). Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth. The International journal of developmental biology, 54(1), 135–140. https://doi.org/10.1387/ijdb.082735hc
  5. Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug design, development and therapy, 9, 2485–2499. https://doi.org/10.2147/DDDT.S82030
  6. Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of clinical endocrinology and metabolism, 91(3), 799–805. https://doi.org/10.1210/jc.2005-1536

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