Research studies in 1973 showed that the administration of Epithalamin was followed by restoring the estrous cycle in old female rats with persistent estrus syndrome. This lowered the threshold of sensitivity of the hypothalamo-pituitary complex to feedback inhibition by estrogens in old animals. Long-term treatment with the preparation has been shown to prolong the animal’s life span, slow down the reproductive system’s aging, improve the immune function parameters and inhibit the development of spontaneous tumors induced by some chemicals or X-irradiation and transplanted tumors.
Multiple Studies Show Epitalon Helped Stabilize Circadian Rhythms
The night release of endogenous melatonin is recovered due to the peptide preparations of the pineal gland, and the circadian hormone rhythm is normalized in the blood plasma. People with pineal gland functional insufficiency show an increase in the night melatonin level, for which Epithalamin and Epitalon have shown modulatory effects in elderly people. The pineal gland preparations effectively increase melatonin concentration and have no side effects.
Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People
Epithalamin (peptide medication) was given along with the regular courses in 39 coronary patients for over three years, while 40 coronary patients (control group) received basic therapy alone. Long-term treatment with epithalamin (six courses over three years) showed a decrease in the aging of the cardiovascular system, age-associated impairment of physical endurance was prevented, and the circadian rhythm of melatonin production lipid and carbohydrate metabolism were normalized. The geroprotective effects of the peptide preparation from the pineal gland were also observed as patients treated with epithalamin and basic treatment showed a significant decrease in mortality rates.
Epitalon Activates Chromatin in Old Age
The function of chromatin is to protect the DNA structure and sequence and effectively pack DNA into a small volume to fit into the nucleus of a cell. The packing of DNA into the chromatin allows meiosis and mitosis, prevents the breakage of chromosomes, and controls the expression of genes and DNA replication.
The activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions are induced Epitalon. Thereby, Epitalon has shown its potential to activate chromatin by modifying the heterochromatin and heterochromatinized chromosome regions in the cells of elderly persons.
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells and Overcomes the Hayflick Limit
Each cell consists of DNA as an instructional guide showing how to divide and grow. The telomeres shield the DNA inside each cell. During cellular division, a new cell takes some telomeres from its originating cell to shield the DNA of the new cell. After every cell division, the telomeres shorten because the new cell can only take a portion of the telomeres from the previous cell; otherwise, the DNA of the previous cell will become completely unprotected.
The division of cells stops when there are no leftover telomeres to take. This happens after a single cell divides and grows about 64 other cells, known as the Hayflick limit, a limit that exists since cells without shielding material are more vulnerable to DNA damage. Suppose the DNA of a cell becomes damaged. In that case, the cell will follow broken instructions because the cell may not be able to eliminate itself through apoptosis-like it is expected to under normal conditions.
The treatment of epitalon to the cells has shown to increase the telomerase enzyme, which strengthens telomeres; therefore, an approximate increase of 33% was observed in the length of the telomeres.
Epitalon Lowers a Type of White Blood Cells Associated with Accelerated Aging
Melatonin prevents the age-specific decrease in the levels of blood lymphocytes in the standard photoperiod. In contrast to melatonin, epithalon has significantly reduced the lymphocyte count and increased the neutrophil count in some age period. During aging, there was an increase in the leukocytes’ alkaline phosphatase activity. As compared with other light conditions, constant light has been shown to promote an early increase in the alkaline phosphatase activity (at 12 months), associated with accelerated development of the pathological process in the organism.
Boosts Endorphins by Inhibiting the Enzyme that Destroys Them
Epitalon has been shown to inhibit the enkephalin-degrading enzymes from human serum.
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