The Anti-Aging Research in Proxofim (FOXO4-DRI) Peptides

by | Mar 4, 2022 | Research

What is FOXO4-DRI peptide?

Proxofim is a recent dutch invention to fight the aging process. It contains a specific peptide antagonist named FOXO4-DRI. In other words, it is a modified type of protein designed to trigger the death of selective old cells. The discovery of this peptide analog has accentuated the attempts for aging reversal. Data suggests promising results during its initial testing in mice. FOXO4-DRI peptide bears the potential to promote longevity, reduce dementia, and suppress tumor cells as well.

For humans, it is natural to wish for an everlasting life full of health and energy. Scientists have long been trying to understand the aging process. We have not found the elixir for eternal youth yet, but research keeps getting us closer to a youthful life. The invention of the FOXO4-DRI peptide is one of the key findings in this attempt to find an effective anti-aging agent.

How does FOXO4-DRI peptide work?

Cellular biologists have found that human cells exhaust after 70 divisions and can no longer produce new cells. There is no way to induce the continual division of cells without any decay. Getting rid of older cells is a viable option to make space for younger cells. Damaged cells tend to spread the decay process as well. Old, decayed cells are suitable for nothing as they produce no energy. In addition, they keep on occupying space within cells and in between cells, hindering the growth of surrounding cells.

FOXO4-DRI peptide mainly works by removing these ‘senescent cells’ that have outlived their usefulness. The most effective senolytic agent to date; ceases the communication of cells with p53 genes and conveys signals that the cell is damaged and needs to be cleared by autophagy. Stem cells produce new cells after the death of old cells. More individual cells replace the older ones culminating in better functioning and longer lives.

Research implications from FOXO4-DRI peptide trials

1- Anti-aging Properties
Aging is a continuous process of natural changes which result in a gradual decline in body functions. The human body consists of billions of cells that act together to make, maintain, and enhance our bodily health in every aspect. Cells further contain smaller subunits called ‘organelles.’ Organelles are smaller and complex structures, and each is responsible for carrying out a specific action.

Two such examples of these cellular entities are mitochondria and lysosomes. Mitochondria is the ‘powerhouse of the cells’ as it generates energy. The energy currency of the body is called Adenosine Triphosphate (ATP). The organisms produce it inside the mitochondria due to several complex reactions. Lysosomes are responsible for removing cellular debris. They work as a dustbin of cells and remove old dead cells. If any of these structures becomes compromised, body functions decline with time.

The effective removal of old cells is the basis for longer life. An accumulation of old dead cells serves no purpose and keeps on occupying space and harming surrounding cells. FOXO4-DRI peptide is supposed to play a role here in removing these decayed old cells.

Experts tested FOXO4-DRI peptide by oral and subcutaneous routes on aging mice by scientific research. Studies found that test mice became healthier as compared to the control group. Mice in the test group achieved better energy levels, enhancing hair growth and improving kidney functions with this protein. Researchers also gave testing mice on chemotherapy substances to see the results of FOXO4-DRI peptide under the stress of this medication. Proxofim was also able to neutralize the toxic side effects of chemotherapy.

2- Potential Diabetes Management
FOXO proteins regulate the signaling of insulin and insulin-like growth factors (IGF). FOXO proteins control cell growth, metabolism, and differentiation through their action on IGF. Mutations in these proteins lead to diabetes, high cholesterol, and even cancer. Future research may explore the effects of FOXO proteins in insulin signaling. This action may improve diabetes management and its related complications.

3- Heart Conditions
Aging leads to a decrease in the function of the heart. Heart conditions mainly result from increased oxidative stress and the build-up of cellular debris. A decline in the action of cellular lysosomes accelerates age-related heart diseases. FOXO-DRI might provide better protection against heart-related conditions by increasing lysosomal activity.

4- Neurodegenerative Conditions
Neurodegenerative conditions such as Parkinson’s and Alzheimer’s result from aging. Some evidence links these neurodegenerative conditions to a decline in the action of lysosomes. FOXO proteins might be able to clear away cellular debris and solve these conditions.

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