Epitalon is a short peptide derived from the pineal gland in the epithalamus region of the brain. It is also known as epithalamine due to its origin of extraction. Vladimir Anisimov conducted studies on this biological peptide. He discovered the active agent of epitalon, a low molecular weight peptide.
Over 25 years, Anisimov extracted and tested the effects of epithalamine peptide for better health and longevity. This mention is the only product that has been scientifically tried and proven in clinical studies in humans.
Potential Benefits of Epitalon
Epitalon is said to be the best finding among all recent peptides. That’s because of its variety of health benefits. It regulates the cell cycle through telomere activity; and suppression of memory tumor genes.
Epitalon peptide changes the action of oncogene expression and increases the lifespan. Research shows that epithalamine is a potent peptide. It has the potential of improving sleep and suppressing oncogenes.
● Resetting the age-related pineal disturbances:
Melatonin levels are higher at night and lower in the daytime. It signals the brain and makes the body ready for sleep. Old age can disturb the release time and quantity of melatonin. Epitalon administration at ten micrograms per animal for ten days resulted in a notable increase in plasma concentrations of melatonin in the animal subjects. It had no effects on the young monkeys. This increase proves that epithalamine can rectify age-related problems of melatonin.
● Inhibition of Rapid Aging of Elderly:
Epitalon tested in different animal species proved its effect on aging. It decreased the mortality rate by 52% in Melanogaster. The reduction was 52% in rats and 27% in mice. Research hinted that the antioxidant properties of this peptide enhanced the lifespan of these three animals species. After animals, epitalon was tested in the elderly with 15 years of follow-up.
Studies showed the long-term effects of epithalamine on the elderly.
These include reduced loss of physical endurance and decelerated aging of the cardiovascular system. Elderly taking epithalamine also had an improved metabolic rate and enhanced melatonin production. Its use improved the circadian rhythm and longevity. This significantly low mortality rate in individuals who took epithalamine has indicated its anti-aging effects.
It also caused a decrease in the number of lymphocytes and increased neutrophils in the old age group. Adequate melatonin stops the early release of alkaline phosphatase (ALP). Higher ALP accelerates the process of aging. A lower level of ALP could mean a decline in the aging process.
● Regulation of Circadian Rhythms:
Our body releases different hormones according to the day and night timings. Our body responds to processes and behavioral changes following a typical pattern known as circadian rhythm. Melatonin is released at night and stimulates the body to relax and nap. Administration of Epitalon hormone improved the night release of endogenous melatonin and reset the natural circadian rhythm.
● Slowing of Leukemia:
Studies on Epitalon found that it inhibited the progression of leukemia in the testing group compared to the control group. It did not influence any spontaneous tumor cells but helped the body prevent leukemia. This fact could mean the effects epithalamine could have on the cell cycle, and it could help the cells to divide in an orderly fashion and prevent complications such as cancer formation.
● Improving the Neural Activity:
Epitalon also improves the neural discharge in old age and patients with low brain activity. Researchers administered a dose of 30 ng of epitalon per animal. Experts measured the neural activity after half an hour. The testing group showed better neural activity than the control.
It could be a potential treatment for age-related brain disorders. These include Parkinson’s disease, Alzheimer’s dementia, and other forms of dementia.
● Induction of Telomere Activity:
Cells cannot give rise to newer cells after completing their 64 divisions. DNA contains a telomere protein, which is present at its ends. When a cell divides, the telomere gets attached to the new partition. It continues to decrease in length. The continued division and shortening of telomeres cause cell death. In studies, Epitalon peptide triggered the telomere activity and increased its size to overcome the cell division limit.
● Activated Chromatin in Old Age:
Chromatin performs the function of packaging DNA into small volumes. This function helps fit DNA into the nucleus and helps protect its structure against damage. This packed DNA allows for division, prevents chromosomes from breakage, and helps in DNA replication. Epitalon activates some ribosomal genes. This activation suppresses the condensation of chromatin to maintain an active status.
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