Epitalon (Epithalon) – A Potential Anti-Aging Peptide

Epitalon is a short peptide derived from the pineal gland in the epithalamus region of the brain. It is also known as epithalamine due to its origin of extraction. Vladimir Anisimov conducted studies on this biological peptide. He discovered the active agent of epitalon, a low molecular weight peptide.

Potential Benefits of Epitalon

Epitalon regulates the cell cycle through telomere activity; and suppression of memory tumor genes.
Epitalon peptide changes the action of oncogene expression and increases the lifespan. Research shows that it has the potential to improve sleep and suppress oncogenes.

● Resetting the age-related pineal disturbances:
Melatonin levels are higher at night and lower in the daytime. It signals the brain and makes the body ready for sleep. Old age can disturb the release time and quantity of melatonin. Studies with monkeys involving Epithalon resulted in a notable increase in plasma concentrations of melatonin in the animal subjects. It had no effects on the young monkeys.

● Inhibition of Rapid Aging of Elderly:
Epitalon tested in different animal species proved its effect on aging. It decreased the mortality rate by 52% in Melanogaster. The reduction was 52% in rats and 27% in mice. Research hinted that the antioxidant properties of this peptide enhanced the lifespan of these three animal species. After animals, epitalon was tested in the elderly with 15 years of follow-up.

Studies showed the long-term effects of epithalamine on the elderly.
These include reduced loss of physical endurance and decelerated aging of the cardiovascular system. An improved metabolic rate, and enhanced melatonin production was noted.

It also caused a decrease in the number of lymphocytes and increased neutrophils in the old age group. Adequate melatonin stops the early release of alkaline phosphatase (ALP). Higher ALP accelerates the process of aging. A lower level of ALP could mean a decline in the aging process.

● Potential Slowing of Leukemia:
Studies on Epitalon found that it inhibited the progression of leukemia in the testing group compared to the control group. It did not influence spontaneous tumor cells but may have helped the body slow it down.

● Improving the Neural Activity:
Epitalon also might improve neural discharge in old age and patients with low brain activity.

● Induction of Telomere Activity:
Cells cannot give rise to newer cells after completing their 64 divisions. DNA contains a telomere protein, which is present at its ends. When a cell divides, the telomere gets attached to the new partition. It continues to decrease in length. The continued division and shortening of telomeres cause cell death. In studies, Epitalon peptide triggered the telomere activity and increased its size to overcome the cell division limit.

● Activated Chromatin in Old Age:
Chromatin performs the function of packaging DNA into small volumes. This function helps fit DNA into the nucleus and helps protect its structure against damage. This packed DNA allows for division, prevents chromosomes from breakage, and helps in DNA replication. Epitalon activates some ribosomal genes. This activation suppresses the condensation of chromatin to maintain an active status.

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