Syn-AKE and Cell Regeneration

by | May 6, 2022 | Research

What Is Syn-AKE Peptide?

The Syn-AKE peptide is a synthetic analog of the protein Waglerin-1. It is a 21 amino acid protein isolated from tropidolaemus wagleri. However, Syn-AKE includes only three of the amino acids which are present in the original endogenous sequence. It represents the perceived active portion of the protein and appears to produce similar action as that of the original Waglerin-1, but researchers assert that it appears to act in a controlled way.


What Are Syn-peptides?

Syn-peptides are synthetically developed peptides similar in structure to a naturally occurring peptide. They typically appear to assume the action of the naturally occurring form. Peptides are short proteins which research posits may indeed be short enough to cross the skin barrier in certain organisms.


How Does Syn-AKE Peptide Work?

Syn-AKE peptide is designed to mimic paralytic action. The Syn-AKE peptide was developed with close structural similarities to the Waglerin-1 peptide. The Waglerin-1 peptide was proposed to induce paralysis in laboratory studies, and the synthetic peptide may potentially produce a similar effect via its chemically similar structure. Researchers believe the molecule may small enough to penetrate the skin barrier. However, only tiny quantities of the molecule has been hypothesized to be able to penetrate muscle cells beneath the skin structure.

Waglerin-1 has been proposed by various researchers to induce sodium uptake by muscle cells by interacting with the mnAchR receptor. Preventing sodium uptake may block the transmission of nerve impulses to the muscles, and the muscles remain relaxed.


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