Syn-AKE and Cell Regeneration

by | May 6, 2022 | Research

What Is Syn-AKE?

The Syn-AKE peptide is a synthetic analog of the protein Waglerin 1. It is a 21 amino acid protein found in the venom of the Malaysian Temple Viper (Tropidolaemus wagleri).

Syn-AKE consists of only three of the amino acids which are present in the original sequence. It represents the active portion of the protein and produces similar effects as that of the original venomous Waglerin but controlled.


What Are Syn-peptides?

Syn-peptides are synthetically made peptides similar in structure to a naturally occurring peptide. They mimic the action of the naturally occurring form. Peptides are short proteins utilized in skincare formulas as they are often tiny enough to travel through the skin. Syn-peptides have been made to combat the appearance of wrinkles and pigmentation and increase natural skin protection.


How Does Syn-AKE Work?

The venom of the Temple Viper- which Syn-AKE peptide is designed to mimic- paralyzes the muscles to weaken their prey. The Syn-AKE peptide was made to mimic this situation by making a synthetic peptide with the same amino acid chains as the Waglerin-1 peptide. The Waglerin-1 peptide was discovered to cause paralysis in the snake’s venom. The synthetic peptide can produce a similar effect by creating a chemically similar structure. Researchers believe the molecule is small enough to penetrate the skin and work on the facial muscles. However, only tiny quantities of the molecule will penetrate the muscles deep beneath the skin. This signifies that Syn-AKE peptide’s effects are generally temporary, lasting for about a month and reducing the likelihood of off-target effects.

The peptide that Syn-AKE peptide mimics are Waglerin-1. Waglerin-1 prevents sodium uptake by the muscles by working on the mnAchR receptor. Preventing sodium uptake blocks the transmission of nerve impulses to the muscles, and the muscles remain relaxed. Just like botox, this relaxation of the muscles may decrease the appearance of fine lines and wrinkles.

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