Triptorelin and its Potential Anti-Cancer Properties

by | Jun 17, 2022 | Research

Triptorelin is a synthetic equivalent of the Gonadotropin-Releasing Hormone. The peptide is used in clinical settings to treat advanced prostate cancer as a factor in approaching androgen-deprivation remedial treatment.

Identical to its effects on Luteinizing Hormone-Releasing Hormone, it is an active inhibitor of estrogen and testosterone synthesis on continuous Triptorelin supplementation over a long period.

In the USA, this peptide is used to censor the synthesis and production of estrogen and testosterone in transgender individuals.


The Role of the Compound in Testosterone Secretion

According to research, the peptide increases testosterone levels with prolonged administration and represses production after exposure to the peptide. This testosterone flare occurs during the first few weeks of triptorelin administration. As a result, Triptorelin may be vital in enhancing testosterone levels in some men depending on the dosage and time of administration.


The Effects of Triptorelin are Dependent on its Application

Triptorelin is a synthetic equivalent of GnRH. Therefore, it can enact the anterior pituitary gland to release Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH). If triptorelin is administered in a steady-state format and not in a pulsatile way, it may eventually suppress the secretion of LH, FSH, testosterone, and estrogen.

Triptorelin functions primarily in the treatment of prostate cancer, where it can lower cancer growth by causing a decrease in testosterone levels. Triptorelin decreases the 10-year death rate in hormone-sensitive prostate cancer to less than 5% while reducing the need for surgery. Still, plans are in place to bolster the benefits of Triptorelin by adding other adjuvants.

Recent research posits that GnRH in symbiont with radiotherapy can show similar benefits as total androgen blockade. The blockade of androgen has several side effects. Reducing the side effects and preserving potency can improve the standard of life and boost treatment adherence.

Triptorelin showed positive results in reducing urinary tract symptoms in men with prostate cancer, bringing the frequency of the symptoms from about 54% to about 12%. These results posit that Triptorelin may help treat benign prostatic hyperplasia and other medical ailments that interfere with urinary function in men.


Protection of Fertility

Chemotherapy causes infertility, particularly in younger individuals. The administration of this peptide in young men that undergo chemotherapy shows that the peptide can preserve fertility in some patients.

Research also shows that Triptorelin can reduce the prevalence of early menopause in patients that have undergone chemotherapy by roughly 17%. The administration of this peptide in women with Adenomyosis may increase the degree of spontaneous pregnancy and better the outcomes of the disease itself. Identical benefits are evident in women with endometriosis.

In endometriosis, triptorelin acts to reduce pain by causing a decrease in the number of nodules in the disease. Research posits that Triptorelin may improve the outcomes of laparoscopic surgery for endometriosis. It is specifically effective in increasing the rates of pregnancy after surgery.

In women with colorectal endometriosis, Triptorelin appears to decrease pain in about 80% of patients and diarrhea in about 60%. Triptorelin does not cure but makes endometriosis manageable.


Triptorelin’s role in Immune Function

Research in mouse models shows that LHRH can impact the thymus and the immune system. Aging reduces the LHRH binding sites on the thymus, resulting in a 50% reduction in thymic mass and function.

The LHRH agonist, Triptorelin, may improve proliferation within the thymus and cause a turnaround in aging effects to some extent.

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