Unique Effects of Sermorelin in Regulating Sleep

by | Mar 8, 2021 | Research

What is Sermorelin peptide?

Sermorelin peptide is a synthetic analog of the naturally occurring growth hormone-releasing hormone (GHRH). GHRH is a 44 amino acid long peptide, and Sermorelin peptide comprises the first 29 amino acids. The shortened peptide is biologically potent like the parent molecule and has been used to address hormone deficiency in animal studies.
Sermorelin peptide (also known as Geref) is used clinically to assess growth hormone secretion, but the peptide is of additional interest for its abilities to:

– Decrease tissue scarring post-cardiac attack

– Enhances bone density

– Improves nutrition in chronic illness

– Enables a better renal function

– Combats the effects of dementia

– Reduces seizure activity


Why do we need to sleep?

The biological purpose of sleep has not been completely deciphered by researchers yet. Sleep influences every tissue and system of the body ranging from metabolism to cardiac function to the brain. Insomnia/chronic lack of sleep leads to various severe physiological disorders, including cardiovascular disease, diabetes, obesity, and depression. Sleep improves overall metabolism, good health, and youthfulness. The quality of sleep experienced is inversely influenced by biological age. Studies have shown that young animals require a lot of sleep. The need for sleep progressively decreases with age.


Effect of Sermorelin peptide on sleep

Animal studies have observed the peptide to reverse the effect of aging on sleep. The production of growth hormone and slow-wave sleep decreases by about two to threefold with progression in age. Sermorelin peptide treatment induces slow-wave sleep, which in turn promotes increased production of GH.

Orexins are metabolic regulators of the sleep-wake cycle. Sermorelin peptide has been observed to influence the function of orexins. GH axis has been conjectured to regulate orexin levels, thereby influencing energy homeostasis. Recent observations prove the regulation of orexins by Sermorelin peptide. The peptide has been effective in the treatment of conditions arising from dysfunctional orexin release. One such condition is a neurological disorder known as narcolepsy, which adversely affects the sleep-wake pattern.


What is Orexin?

The brain possesses relatively less abundant orexin neurons-about 10,000 to 20,000. Orexin neurons are better known as hypocretin. They are prevalent throughout the brain and spinal cord. Cognate receptors for orexin are also present throughout the nervous system. Orexin receptors are often terms as “multi-tasking” as they regulate metabolism, energy homeostasis, sleep-wake patterns, feeding behavior, mood, cognitive ability, and reward systems. Dysregulation experienced in the oxinergic system can lead to pathological conditions. Due to its regulation of fat metabolism, a deficiency in orexin receptors causes obesity and narcolepsy. On the other hand, excess of the receptors leads to a significant alteration in reward-seeking behavior. Modulation of orexin brings positive outcomes in treating medical conditions like overeating, addiction, and other medical conditions. Sermorelin peptide indirectly promotes orexin neurons and thus increases the overall level of orexin in the nervous system.



The connection between Sermorelin peptide and sleep is still subjective to further study as many aspects are hitherto unknown. An important aspect of the study is to explore the function and regulation of sleep and the influence of Sermorelin peptide towards improving the condition of sleep. Sermorelin peptide is not yet available for human or animal consumption.


Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.