Sermorelin (5mg)

(18 customer reviews)


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What is Sermorelin Peptide?

Sermorelin is among the growth hormone releasing hormone (GHRH) analogs developed in recent years. It aims to maintain the positive effects of natural GHRH and overcome the adverse outcome of GHRH. Sermorelin (Geref) is used clinically to assess growth hormone secretion, but the peptide is of additional interest for its abilities to:
– Decrease tissue scarring after the  cardiac attack.
– Improve bone density.
– Enhance nutrition in chronic illness.
– Improve renal function.
– Combat the effects of dementia.
– Reduce seizure activity.


Molecular Formula: C149H246N44O42S

Molecular Weight: 3357.9 g/mol

Sequence: Tyr-Ala-Asp-Ala-lle-Phe-DL-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

PubChem: CID 16129620

CAS Number: 86168-78-7

Reconstitution: Required

Sermorelin Research

Sermorelin and Cardiac Health
Cardiac attack, apart from being fatal, can also cause long-term disability secondary to cardiac failure, cardiac conduction abnormalities (arrhythmias), decreased exercise capacity, pain, and more. A number of these issues arise from cardiac remodeling due to damaged myocytes (heart muscle cells). Often, it leads not only to scarring of tissue in the area of damage following a cardiac attack but extends to surrounding healthy tissues as well. Cardiac remodeling leads to long-term problems, and prevention helps to improve outcomes both immediately after a heart attack and years down the line.
In 2016, a study in pigs showed that sermorelin use helps to reduce the remodeling after a cardiac attack. The research showed that sermorelin:
– Decreases cell death in cardiomyocytes.
– Improves the production of extracellular matrix components needed for adequate healing.
– Promotes angiogenesis to damaged tissue.
– Reduces the production of pro-inflammatory substances.
Clinically, it enhances diastolic function, decreases scar size, and increases capillary growth. It is being explored for different cardiac diseases like a cardiac failure and valve disorders.

2. Epilepsy
Gamma-aminobutyric acid (GABA) is a central nervous system signaling molecule that decreases electrical activity in the spinal cord and reduces overall electrical excitability in the central nervous system. Many anti-seizure medications work either to, enhance levels of GABA in the central nervous system or mimic GABA by binding to GABA. In a recent murine model with epilepsy, scientists administered sermorelin to study the effect on seizure activity. GHRH analogs were observed to activate GABA receptors and inhibit seizures. This will open avenues for new drugs as the existing ones have adverse effects.

3. Sermorelin and Sleep
Orexin is a powerful neurochemical secreted by certain neurons in the brain. It has been observed to regulate sleep cycles. Growth and healing of the body by the growth hormone secretion happen maximally during sleep. Studies have found that a functional GHRH axis is required for orexin production and function. In addition, exogenous administration of sermorelin and other GHRH agonists enhances orexin secretion. Sermorelin is being studied to improve sleep disorders.

4. Sermorelin Peptide is Preferred to Growth Hormone
Sermorelin is a growth hormone-releasing hormone derivative that mediates the beneficial effects of GH but not its side effects. Sermorelin is used to increase GH levels in humans over direct use of the hormone itself as the peptide can be regulated through physiological feedback mechanisms that prevent side effects of GH. The adverse effects include overdose, improper dosing, and unintended side effects like edema, joint pain, and dysregulation of normal physiology.
A second reason for sermorelin preference is that it is not subject to tachyphylaxis, the process by which the body becomes acclimatized to a medication dose and requires higher doses to achieve desired effects. In certain cases, tachyphylaxis is so aggravated that a drug holiday (complete stoppage of drug use) is essential to regain the effects of medication. Studies have shown that the body has a unique response to the long-term administration of sermorelin. The body enhances the production of GHRH receptors instead of downregulating them. This prevents the onset of tachyphylaxis and thus the effect of sermorelin is maintained without increasing its dose.
The peptide exhibits moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not match up to human requirements.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

18 reviews for Sermorelin (5mg)

  1. Hughes Evelyn

    Thumbs up for amazing service

  2. Eleanor Calder

    Great product. Honest seller.

  3. Mila Atken

    A+ service and quality

  4. Laurie Barnes

    Shipping was fast. sent out the same day.

  5. Jennifer Vachon

    If you are new like I was, I highly recommend you give them a try. You won’t regret it.

  6. Nathan Cragun

    If I could rate them higher I would

  7. Esther C.

    Incredibly swift and smooth ordering process, professional communication, and excellent quality of products.

  8. Brent Wolfe

    Packaging is always discreet and tamper evident. They go the extra mile.

  9. Kelli Dougal

    Pleasure working with them. Had a few vials come in broken! Called them and they were able to get new ones sent over.

  10. John Rowekamp

    Love that it’s a local and reliable company, I get shipments super fast and happy I don’t need to order from out of state!

  11. Addison Long

    I like that they send out promo codes as often as they can. They are already one of the cheapest places to buy peptides but that extra little money saver is excellent!

  12. Phil W.

    I recently bought peptides from Biotech. They came highly recommended to me and I can see why.

  13. Nick kesler

    Biotech has great service! Dani is the person I bother for everything weather its to fix a mistake on my end or to place a big order that could be more difficult to do online.

  14. antonio ricci

    As far as peptide companies go, they are the best I have found in the past 5 years. They are not that old of a company but they’re beating out the ones that are.

  15. Connie Aracena

    Peptides are okay for the cost, and so far I have had no reason to contact customer service.

  16. Nikko Guzman

    Satisifed customer. From begining to end had great customer service and the peptides are perfect for what they cost.

  17. Andy Benavides

    Smooth and fast check out process! No extra loops to jump over when checking out.

  18. Stepan Thorn

    New to peptide research and a friend actually recommended them. Have been doing some research and they have the best priced Peptides around and the products are of the highest quality. Looking forward to getting to use them and see what they can do for my research.

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