Unique Potential of Sermorelin Peptide in Regulating Sleep

by | Mar 8, 2021 | Research

Sermorelin peptide is a synthetic analog of the naturally occurring growth hormone-releasing hormone (GHRH). GHRH, a 44 amino acid long peptide, comprises the first 29 amino acids of Sermorelin peptide. This shortened peptide is thought to be biologically potent akin to the parent molecule and has been examined in animal studies to address hormone deficiency.

Sermorelin peptide has been evaluated in research studies to determine its impact on growth hormone secretion. Research in the peptide has lead to a diverse set of hypotheses related to the peptide’s physiological impact, summarized here:

  • Potential anti-fibrotic impact on cardiac tissues post-attack
  • Potential increase in bone density
  • Potential improvement in renal function
  • Potential in neurological dysfunction including dementia
  • Potential reductive action in seizure activity
  • Potential regulation of sleep/wake cycles


Sermorelin Peptide and Sleep Research

Animal study findings observed the peptide to potentially reverse the impact of cell aging on the circadian rhythm and sleep-wake cycle. The production of growth hormone and slow-wave sleep purportedly decreases with time, by about two to threefold. Sermorelin peptide exposure was suggested to induce slow-wave sleep, which in turn may promote increased production of growth hormone.

Orexins, considered to be metabolic regulators of the sleep-wake cycle, may potentially be influenced by Sermorelin peptide. The growth hormone axis has been conjectured to regulate orexin levels, thereby influencing energy homeostasis. Recent observations suggest the regulation of orexins by Sermorelin peptide. The peptide was evaluated by research teams within the context of conditions arising from dysfunctional orexin release, such as a neurological disorder known as narcolepsy, which adversely affects the sleep-wake pattern.


Orexin-Sermorelin Correlation

The brain appears to possess relatively fewer abundant orexin neurons, estimated to be about 10,000 to 20,000. Orexin neurons, also known as hypocretin, appear prevalent throughout the brain and spinal cord. Cognate receptors for orexin may also be present throughout the nervous system. Orexin receptors are often termed as “multi-tasking” as they may potentially regulate metabolism, energy homeostasis, sleep-wake patterns, feeding behavior, mood, cognitive ability, and reward systems. Dysregulation experienced in the oxinergic system may potentially lead to pathological conditions. Due to its speculated regulation of fat metabolism, a deficiency in orexin receptors may cause obesity and narcolepsy. On the other hand, an excess of the receptors could lead to a significant alteration in reward-seeking behavior. Modulation of orexin may bring positive outcomes in mitigating the onset of specific conditions. Sermorelin peptide might indirectly promote orexin neurons and thus increase the overall level of orexin in the nervous system.


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