PT-141 ( bremelanotide ) has a molecular mass of 1025.2 grams per mol. and its chemical formula is C50H68N14O10.

Systematic Name (IUPAC)

(3S 6S 9R 12S 15S)-15-[(N-acetyl-L-norleucyl)amino]- 9-bynzyl-6-{3-[(diaminomethylidine)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaa zacyclotricosane-23-carboxylic acid is the systemic name for PT-141.

 

Pharmacokinetic and other information

Bremelanotide is considered ‘unscheduled’ by the United States government at present which indicates that PT-141 is not regulated by law.

Half-life of a compound is defined as the time it takes for the compound to reduce half of its potency value. Bremelanotide has a half-life of about 2 hours.

 

Bremelanotide: The Biochemical Process

PT-141 has been observed to influence the central nervous system directly. Animal studies have revealed the molecule to stimulate both synthesis and activation of the MC-4R and MC-3R melanocortin receptors. Findings suggest that the reaction itself controls certain signals from the brain to the body. The signals regulating blood flow and inflammatory response are specifically suppressed. The brain is enabled to moderate the signals better once the switch to these specific receptors gets altered by the molecule.
Bremelanotide and Reperfusion Shock
Organ tissues are known to suffer from ‘reperfusion damage’ when they have been cut off from the blood supply by any occurrence such as a stroke. When the healthy state gets restored, renewal of blood supply can create a surge of oxygen into the affected tissue leading to oxidative stress.
Such injuries in smallest of tissues can be fatal as they often lead to strokes or cardiac arrests and even result in complete failure of brain function. PT-141 works on the neurological circuit of our body thereby activating the receptors which stabilize the signals related to the restriction of blood flow, thereby easing, if not completely stopping, the chances of occurrence of reperfusion shock.

Hemorrhagic Shock and PT-141 Interaction

Bremelanotide, helps to control the proper blood circulation in the brain through stimulation of neural flexes. Hemorrhagic shock results from a ‘lower tissue perfusion’ or the administration of oxygen to the tissue manually through a variety of methods, which tends to worsen due to increased lack of oxygen to the area over time.

Hemorrhagic shock can be classified into following four types:
Neurogenic
Cardiogenic
Septic (or ‘vasogenic’)
Hypovolemic
Treatment of these four types can be difficult individually as even at a cellular level as the responses are different between two individual cells.

Current related research and findings regarding PT-141 (Bremelanotide)

The peptide has been studied till date on animal models only. The studies have been conducted in controlled and stabilized environment. The drug is still in an active research space. Hence it is strictly recommended to be used for research and in a supervised manner. The plans to conduct a clinical study involving on the peptide in 2007 was postponed as the drug was observed to trigger increase in blood pressure and can be fatal in many situations.

Developmental information regarding Bremelanotide

Bremelanotide (PT-141) is direct derivative of the peptide hormone ‘Melanotan II’. It was developed as a sunless tanning compound because of its direct influence on skin tone.During the course of development the peptide also showed to be effective in female arousal as well as causing erections in males on a spontaneous basis. Such findings were not expected and occurred in 90% of male subjects used in the study.

In 2012 a study was conducted wherein administered PT-141 was administered to premenopausal female subjects, and high-level results were reported all across the cohort, showing effectiveness in the treatment and significant reduction of a number of diverse menopausal symptoms which usually manifest.

The influence of Bremelanotide on the libido of either gender has been found to work in absolutely different pathway when compared to enhancement drugs such as Cialis or Viagra, both of which alter the blood flow to the sex organs. Rather PT-141 has been proven to trigger sexual desire by invigorating the parts of the brain which control sexual desire, thereby improving libido and performance. To date the peptide has continued to be closely studied and monitored, and is currently readily available for purchase for research only as the FDA approval is pending. Use of any supplement or medication that is not FDA approved can be dangerous and may cause serious health issues. 

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

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