PT-141 (Bremelanotide) (10mg)

(39 customer reviews)

$38.00

Discount per Quantity

QuantityDiscountPrice
5 - 95%$36.10
10 +10%$34.20
SKU: PT-141-10mg Category:

Description

What Is PT-141 Peptide?

PT-141, also known as bremelanotide, is occasionally called the female Viagra. It was previously investigated in phase IIb human clinical trials to treat female hypoactive sexual desire disorder (HSDD). It is derived from another synthetic melanocortin known as melanotan 2 (MT-2). PT-141 is a melanocortin that  interacts with melanocortin 4 receptor (MC-4R) and MC-1R. In 2009, PT-141 was studied for treating acute hemorrhage.

PT-141 SPECIFICATIONS

AKA: Bremelanotide

Molecular Formula: C50H68N14O10

Molecular Weight: 1025.2 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

PubChem: CID 9941379

CAS Number: 189691-06-3

Reconstitution: Required

Research related to PT-141 (bremelanotide)

PT-141 Peptide and Sexual Arousal
PT-141 uniquely stimulates MC-4R, which triggers sexual arousal in the central nervous system and affects sexual behavior. Studies in mice agonist binding to MC-4R bring sexual arousal and enhanced copulation in both males and females. The mechanism of PT-141 beings different from Viagra; it helps to treat both male and female sexual arousal disorders that are not caused by reduced blood flow to the genitals.
One-third of men who suffered from erectile dysfunction (ED) but did not respond to sildenafil (Viagra) experienced satisfactory erection for sexual intercourse using PT-141 (administered via nasal spray). The strong dose-dependent response in the trial indicated the effectiveness of PT-141 in some cases. PT-41 thus can be helpful to treat ED when Viagra is non-responsive.
Interestingly, it was removed from clinical trials for treating women with HSDD despite showing increased female sexual satisfaction and reducing female sexual distress scores without side effects. Experts on female sexual dysfunction (FSD) consider a lack of established endpoints for trials of FSD and socio-cultural biases against women’s sexual health as the essential reasons for the  non-approval of PT-41. Experts are hopeful for FDA to issue concrete guidelines for evaluating trials of such potential drugs. They also suggest the PT-41 treatment if combined with other existing modalities will enhance both physiological and psychological efficacies.
In 2017, partly due to the outcry against the cessation of earlier trials, Phase II Reconnect trials were initiated for subcutaneous injections of PT-141 for FSD. The newest variant of PT-141, called Rekynda, might soon be marketed for use in the United States. PT-141, at that point, could be used off-label for treating both male and female sexual dysfunction. The new trials abided by the modified endpoint for effective clinical trial evaluation of such drugs in the treatment of FSD.

Infection
The MC-1R has shown to mediate important anti-fungal and anti-inflammatory effects in a rat model of specific fungal infection. This will be relevant as current drugs have limited mechanisms of action and show adverse effects in some patients. The alternative therapy can control morbidity and mortality, especially in immunocompromised patients.

PT-141 and Hemorrhage
In 2009, modified PT-141 was investigated for use in hemorrhagic shock. The peptide controls ischemia and protects tissues against inadequate blood supply  hypovolemic (hemorrhagic) shock through interaction with both MC-1R and MC-4R. It was further observed in phase IIb trials that the intravenous dose of the drug shows no side effects. The modified version is referred to as PL-6983.

Cancer Research
The MC-1R receptor being an important stimulus of DNA repair pathways, is of relevance in cancer treatment and prevention. People with variants of MC-1R are more prone to both basal cell and squamous cell carcinoma. Altered PT-141 can be used to bind to these variants and prevent or treat these cancers.

Research Directions

Right now, PT-141 is well known for the treatment of sexual dysfunction. There is potential to expand its use for other diseases. For instance, a mutant or deleted MC-4R triggers some instances of obesity and influence about 6% of early-onset obesity cases. PT-141 helps to study this specific reason for obesity and illustrates a pathway for intervention. MC-1R is involved in pain, inflammation, kidney pathology, and the spread of infection; the peptide helps investigate diverse research domains.
PT-141 exhibits minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage (per kg) in mice does not match humans.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

39 reviews for PT-141 (Bremelanotide) (10mg)

  1. Liam Lewis

    Amazing product. I wll be back for more

  2. Liam Lewis

    I found this product to show visible results

  3. Kamari Clark

    Ive ordered twice so far and my bacteriostatic water was missing. Well, it was my fault for not having met the minimum purchase requirement but I was sent one free of charge and they even covered shipping. What more could I ask for. Thank you team at Bio

  4. Felix Stewart

    Great and fast customer service.

  5. Samuel B.

    I highly advise buying peptides from this particular company. They are very transparent

  6. London Wright

    I find this company and its products to be excellent.

  7. Jose Gonzalez

    very good

  8. Leigh Mueller

    Having a reliable peptide source in the United States is a huge blessing for me.

  9. Hayden Foster

    Not sure what happened but we got a few vials that were broken. My company has ordered products from here before with no issues so could be from shipping. They apologized and sent out new ones with overnight shipping. Also threw in a discount code for our next time.

  10. Jean-Carlo Lopez

    Servicio increíble!

  11. James Avenoso

    Please introduce a punch card or something or coupon codes. I’ve brought you a lot of clients and I would love to maybe get a 5% discount for every person using my code

  12. Christian Mendoza

    They have been out of stock of the paticular peptide I need for weeks now. So decided to call and see what was up. They we’re about to get some out shortly and just took my order and payment over the phone. Even threw in a discount because the wait was so long.

  13. Joe McConnell

    Taylor is magnificinet and truly knows their stuff. Anytime I have contacted them to correct something or if i have any questions they were always on top of it and had an answer.

  14. Geroge Salvini

    Had an issue where all my peptide vials came in either broken or completely degraded. Right away reached out to customer service as something went wrong from once it left the facility to ending up at my lab. They were kindhearted enough to put in a rush order for me free of charge and send in a discount code to use for the next few transactions. Now any peptide company could resend orders, but it was the “no problem” attitude and great CS that sets them apart for me.

  15. Matty Donovan

    Great supply of peptides. Like that they take different payment methods!

  16. Gabriel Miller

    Peptides have always come in great condition. I like that they always have the Pt-141 on stock anytime I need it!

  17. Ali Murphy

    I belive their products are one of the best in the market. Can count on them for good quality.

  18. Richard S.

    Great new company, excited to see how they grow.

  19. Declan Walker

    Best prices I have found for this particular peptide. Noticed a lot of your pricing is less that other places as well.

  20. dennis long

    Good source to get Peptides from.

  21. C. Carter

    Had a diffciult time with customs! As I live in Canada there was a whole ordeal with getting the peptides in time. What should have been a two day shipment turned into almost 2 weeks. At that point I knew there’s no way the peptides would be in good condition but I had hope. Low and behold my assumption was right and all the peptides went straight to waste. I contacted Biotech to let them know what was going on. Thankfully they were able to rush me a new order and this time no issues with customs.

  22. Jeremy Schablewski

    Service is unbeatble. The service reps always have an answer to my questions and know a lot about the products and the company itself.

  23. Chad Dela Cruz

    Could not believe how great the qulaity is for the price.

  24. Arthur McAllister

    Amazing company and products. Will buy again

  25. Marco Gonzalez

    great quality, Have ordered with them a few times, have not had a bad experince yet.

  26. Vinny Haley

    Peptides arrived on time. Used it for the first time and my research reacted well to it.

  27. Gavin Markowitz

    Nice selection of peptides, did not see a specific few that I was looking for however.

  28. Danny Williams

    I like how their customer service is always well informed and up to date on all the peptide information. Very helpful staff

  29. Dan Benaroch

    Ordering in bulk from them is so easy, compared to other places I have shopped before

  30. Gabriel Browndorf

    Products are pure. Top 5 peptide companies in my book.

  31. Henry Chan

    Found them off google, happy I did.

  32. Wendy Martinez

    I wish I could give this company more than 5 stars, great in every way

  33. Javier Laurent

    I find it pretty difficult to find this product online on other suppliers’ websites, but Biotech always has everything I need

  34. Edmond Amataj

    Good quality stuff for a great price, no complaints

  35. Danny Hendricks

    Research results are no different with any other peptide source, however the service and fast shipping is what makes biotech my supplier of choice.

  36. Jess Jiang

    Great stuff!

  37. Praneel Gulabrao

    Fantastic service on their end

  38. Mitchell Mauldin

    Been buying their products for months now and can say It’s the best place to get peptides from

  39. Geri Coleman

    I always recommend them to those doing peptide research. Clean and pure peptides as well as great customer service and prices.

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