What is PT-141, and how does it help with erectile dysfunction?

PT-141 is a peptide derivative of Melanotan 2, which in turn is a synthetic variant of a peptide hormone alpha-melanocyte-stimulating hormone.
Studies have shown that PT-141, also known as Bremelanotide, enhances libido by stimulating the melanocortin receptors MC1R and the MC4R without promoting any tanning. This helps to treat female sexual dysfunction and male erectile dysfunction. The peptide acts through the nervous system instead of the vascular system. The MC-4R produces arousal in the central nervous system, thereby influencing sexual behavior. Upon administration at recommended dosage, the peptide acts within 30 minutes, and the effect can be experienced up to 12 hours. The results can last up to 3 days with a gradually diminishing effect with each day.
The peptide enhances the desire to increase blood flow in the vagina and the clitoris, which returns the feeling of intimacy and passion.
Erectile dysfunction can appear to be a major challenge towards a happy marital life and maintaining a healthy sexual and emotional relationship. Stress, anxiety, and underlying physiological reasons can lead to erectile dysfunction in men. PT-141 has been found to be a wonder molecule that helps to address the ED issue.

The history of PT-141 and Melanotan II

Various studies in the early 1960s demonstrated the influence of melanocyte receptor stimulators that caused sexual arousal in rats.
By the year 1980, analogs of the melanocyte receptor stimulators were developed and were found to be potential tanning agents. Some of those analogs introduced Melanotan-I and Melanotan-II.
One of the scientists, upon self-administration of Melanotan with twice the dose, experienced erection for eight hours.
Further results led to the identification of PT-141 as the active component of Melanotan II, which was responsible for sexual arousal.

Prescribing protocol of the PT-141

For males without erectile dysfunction, 1mg (0.1mL) can be injected via subcutaneous injection in the lower right quadrant of the abdomen 45 minutes prior to the sexual activity.
Males suffering from ED and don’t respond well to Sildenafil 100mg may begin with 4mg (0.4m:) via subcutaneous injection. The administration strategy would be the same as above.
Females with FSAD or HSDD are recommended 750mcs-1mg (0.075mL-0.1mL) via subcutaneous injection 45 minutes prior to the sexual activity. The peptide is recommended to be used only up to two times per week.

What are the benefits of the PT-141?

As mentioned, PT-141 can:
– Enhances sexual desire and performance
– Promotes self-esteem and confidence
– It helps to improve your relationship with your partner.

The other benefits are as follows:


The PT-141 is being investigated as a treatment for acute bleeding as it reduces ischemia by binding both the MC-1R and the MC-4R. It can thus protect the tissues against the inadequate blood supply in the setting of hypovolemic shock.


MC-1R has been observed to possess significant anti-fungal and anti-inflammatory properties. Hence, the PT-141 may be considered an alternative treatment in fungal infections because of its ability to activate the MC-1R.


The MC-1R receptor stimulates the DNA repair pathways. Hence the variants of PT-141 hold promise in terms of treating specific cancers.

What are the effects of the PT-141?

In men
The PT-141 helps to treat sexual dysfunction, such as impotence or erectile dysfunction, and premature ejaculation. Its mode of action is different from Viagra and thus can be used to treat sexual arousal disorders in men and women due to reasons besides reduced blood flow to the genitals.

In women
The PT-141 is the only known medication that can quickly enhance sexual performance and libido in women. It can also promote sexual health. Thus the peptide contributes towards enhanced libido and female sexual fulfillment.

The following may be points you should consider to check if you are a candidate for PT-141:
– Lack of desire and receptiveness in any sexual activity
– Inability to become aroused
– Reduced sensation
– Pain during intercourse
– Inability to achieve an orgasm

Emotional issues like:
– Anxiety
– Embarrassment
– Shame
– Decreased interest in sex

The bottomline

PT-141 is a peptide hormone that acts as a potential treatment for erectile dysfunction and can help rejuvenate sexual vigor. However, doctors’ recommendation is important to rule out chances of any potential complication triggered by the peptide hormone won’t cause any complications in the body.


Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

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