Comparing CJC-1295 and CJC-1295 with DAC Peptides

by | Apr 22, 2022 | Research

The CJC-1295 peptide is available in two forms: CJC-1295 and CJC-1295 DAC.

The name is different, but the two peptides have a lot of differences.
CJC-1295 DAC is similar to CJC-1295 in structure but has a small motif added to it at the end. That piece is the ‘Drug Affinity Complex (DAC).’
This small addition has significant effects on how the two peptides work.

The most crucial difference it creates is its effects on the half-life of the peptide. This small change increases the half-life of CJC-1295 DAC by 6 to 8 days. This enhancement means the product can remain in the subject’s system for that much time and can produce its clinical effects.

Let’s dive into the details of what makes these peptides different. Let’s get to it.

What is CJC-1295?

CJC-1295 has several names. It is also known as the ‘Modified GRF (1-29)’ or ‘Mod GRF 1-29‘. All these compounds refer to the same peptide compound. This peptide is smaller in structure compared to the original protein.

CJC-1295 is a synthetic substitute for Growth Hormone Releasing Hormone (GHRH). Due to its resemblance to GHRH, CJC-1295 can cause a significant increase in GH levels. Growth Hormone (GH) is a body hormone produced by the thalamus in the brain. It controls several body functions. These functions include glucose metabolism, lipid breakdown, bone health, skin health, and blood pressure regulation. Some other effects include preventing signs of aging and improving overall well-being.

The growth hormone levels do not remain constant as you age. Instead, they fluctuate with age. The levels are highest when you hit puberty. That’s why individuals experience a spurt of growth during their years of puberty. After that, the growth hormone experiences a rapid decline. Its levels reach a significant low in the 50s and continue to decline further in the 60s. That’s why elderly individuals experience effects such as visible signs of aging and a decline in bone health.

Due to its ability to mimic the action of GHRH, the peptide can act on the growth hormone-releasing receptors of the brain. This receptor signals the brain to make more growth hormones. It is an effective strategy for increasing growth hormone levels. It is also effective in reversing the signs of growth hormone deficiency with increasing age.

What is CJC-1295 DAC?

As mentioned, CJC-1295 DAC has a structure similar to CJC-1295. The only difference is that it has a small addition called ‘Drug Affinity Complex (DAC)’ attached to the end of the peptide.

DAC consists of a few nitrogen and oxygen atoms. But this small change can significantly affect how the body treats CJC-1295 DAC compared to CJC-1295.

The 4 Major Differences Between CJC 1295 and CJC 1295 DAC

1. Change in Half-Life

The main difference between the two molecules is the effect on half-life.
CJC-1295 has a structure similar to the body’s GHRH. The half-life of the peptide is too short. It lasts only 30 minutes. This amount of time is a significant limitation.

CJC-1295 DAC, on the other hand, has a longer half-life. The DAC end of CJC-1295 allows it to bind to the albumin proteins in the body. This binding allows the peptide to remain in the body longer and prevents the peptide’s early metabolism.

This small addition to Mod GRF 1-29 causes a dramatic increase in its half-life. Compared to the CJC-1295 peptide, the half-life of CJC-1295 DAC is approximately 6 to 8 days.

2. Change in Dosage and Frequency

Since CJC-1295 has a short half-life, you might need to take a higher dose more frequently. Since GH levels rise and fall in a pulsatile manner, you need to take CJC-1295 almost every day during the GH cycle. Only then will you see the physiological effects of CJC-1295.

On the other hand, CJC-1295 DAC has a longer half-life. You can take a dose only once or twice a week to see favorable outcomes.

3. Difference in Applications

The applications of both peptides are similar. However, there are subtle differences. CJC 1295 DAC affects soft-tissue growth and might help tissue growth after surgery.

Otherwise, both peptides have similar benefits. The peptides help with glucose metabolism, sleep regulation, lipid clearance, and overall well-being.

4. Difference in Dietary Restrictions

Since CJC-1295 has a short half-life, some prerequisites need to be met to obtain maximum benefits.

To ensure CJC-1295 exerts maximum benefits, you need to take it on an empty stomach. You also need to avoid eating for at least 30 minutes after eating.

Since Mod GRF 1-29 has a long half-life, there is no need to follow any dietary restrictions.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.