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Mod GRF 1-29 (CJC-1295 NO DAC) (5mg)

Mod GRF 1-29 (CJC-1295 NO DAC) (5mg)

(24 customer reviews)

$46.00

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SKU: Mod-GRF-1-29-5mg Category:

Description

What is the Mod GRF (1-29) Peptide?

Mod GRF (1-29) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It was first developed in the 1980s when studies revealed that the first 29 amino acids of GHRH possessed all of the biological roles associated with the full-length 44 residue protein.[1] The initially designed peptide, known as GRF (1-29), is the shortest segment of GHRH, and appears to possess all the properties of the full-length hormone. A different truncated synthetic form of GHRH known as Sermorelin or GRF 1-29 also has 29 amino acids. Modified GRF (1-29) undergoes alteration to include four substituted amino groups in its chain.[2] The intention behind these amino modifications is to protect the peptide from both oxidation and degradation during manufacture and transport and in vivo. The modification also appears to increase the binding affinity to GHRH receptors. Though GRF happens to be biologically potent like GHRH, the duration of action is restricted due to a short half-life (less than 10 minutes). As a result, researchers have modified it hoping to enhance its half-life with better therapeutic potential. Modified GRF (1-29) is also known as Mod GRF or Tetra-substituted GRF (1-29). The latter name clarifies that the modified peptide differs from GRF (1-29) as a result of changes in four of its amino acids. Modified GRF (1-29) is identical to CJC-1295 without DAC.

Specifications

AKA: Mod GRF (1-29)

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

PubChem: CID 56841945

CAS Number: 863288-34-0

Reconstitution: Required

Mod GRF (1-29) Research

Modified GRF has been studied for its potential to mediate the same biological effects as GHRH, including muscle growth (hypertrophy), improved bone development, enhanced lipolysis, accelerated metabolism, and wound healing. It also may positively influence the immune system and blood sugar regulation.

Modified GRF 1-29 and Cardiac Function
Research in rodent models has observed that modified GRF and other GHRH derivatives may improve the capacity of the heart to pump blood even after a heart attack.[3] More specifically, the researchers comment that “Various studies demonstrate that GHRH agonists promote repair of cardiac tissue, producing improvement of ejection fraction and reduction of infarct size in rats, reduction of infarct scar in swine, and attenuation of cardiac hypertrophy in mice.” This could be of immense potential in improving the quality of life and reducing death over the long term in patients diagnosed with cardiac failure. Modified GRF has the potential to be effective in the treatment of pulmonary hypertension, cardiac failure, heart attack, and diverse congenital heart conditions.

Modified GRF 1-29 and the Intestine
Early studies have highlighted that growth hormone (GH) may be beneficial for Crohn’s disease, short bowel syndrome, and other inflammatory bowel conditions. Unfortunately, the adverse effects of long-term use exceed the benefits of the hormone. Thus, researchers have looked into GHRH analogs for mediating a similar effect. Research in monkeys suggested that Mod GRF 1-29 binds with vasoactive intestinal peptide (VIP) receptors and improves bowel motility, as improved bowel movement is crucial in inflammatory bowel diseases associated with constipation. The peptide appears to interact with VIPC1, present on the smooth muscle of the reproductive, gastrointestinal as well as urinary systems.[4] [5] These conditions trigger a great deal of morbidity and are difficult to address due to the lack of alternative drug options.

Mod GRF 1-29 and Thyroid, Growth Hormone
Malfunctioning of the thyroid gland is often associated with concomitant issues in GH release. Research studies have suggested that individuals who suffer from hyperthyroidism and receive the thyroid replacement hormone demonstrate stronger reactions to GRF, providing a possible a link between thyroid hormone and GH.[6] The scientists commented that “These data indicate that thyroid hormone […] enhances the responsiveness of the somatotroph to GRF 1-29.” Thus, peptides like Modified GRF may contribute towards a better understanding of human physiology. Experimental studies in Modified GRF 1-29 note that the peptide appears to exhibit mild side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage required in mice (per kg) does not scale to that suitable for humans.

References

  1. Cen, L. P., Ng, T. K., Chu, W. K., & Pang, C. P. (2022). Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection. Neural regeneration research, 17(12), 2643–2648. https://doi.org/10.4103/1673-5374.336135
  2. Jetté, L., Léger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D. P. (2005). Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology, 146(7), 3052–3058. https://doi.org/10.1210/en.2004-1286
  3. Schally, A. V., Zhang, X., Cai, R., Hare, J. M., Granata, R., & Bartoli, M. (2019). Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology, 160(7), 1600–1612. https://doi.org/10.1210/en.2019-00111
  4. Ito, T., Igarashi, H., Pradhan, T. K., Hou, W., Mantey, S. A., Taylor, J. E., Murphy, W. A., Coy, D. H., & Jensen, R. T. (2001). GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides, 22(7), 1139–1151. https://doi.org/10.1016/s0196-9781(01)00436-3
  5. Waelbroeck, M., Robberecht, P., Coy, D. H., Camus, J. C., De Neef, P., & Christophe, J. (1985). Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology, 116(6), 2643–2649. https://doi.org/10.1210/endo-116-6-2643
  6. Valcavi, R., Jordan, V., Dieguez, C., John, R., Manicardi, E., Portioli, I., Rodriguez-Arnao, M. D., Gomez-Pan, A., Hall, R., & Scanlon, M. F. (1986). Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clinical endocrinology, 24(6), 693–698. https://doi.org/10.1111/j.1365-2265.1986.tb01666.x
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Biotech Peptides

24 reviews for Mod GRF 1-29 (CJC-1295 NO DAC) (5mg)

  1. Gabriel Miller –

    You get what you pay for. I had found antoher cheaper supplier but I think it was bunk. no effects whatsoever. The results were obvious with this product after ordering here/

  2. Noah White –

    The website is easy to use, orders are easy to track, products arrived on time and everything was as it was promised to be

  3. Luca James –

    Everything went very smoothly so far. I am very pleased with the experience

  4. Beckett Black –

    This product is a Holy Grail

  5. Blake Rivera –

    Everything was as expected

  6. Heather Watson –

    Very transparent staff. I love it

  7. Rachel Wilkens –

    The company I work for has researched a bunch of peptide companies over the years and as soon as BP came on the market, we gave it a shot and never switched suppliers again

  8. Ken Eberle –

    Retrun time is great. Had an issue with payment and put the wrong payment method. Taylor was the one I was emailing with, they were able to fix that right up for me.

  9. Simon Cambell –

    There’s some shitty quality stuff out there. Biotech’s peptides are not one of them.

  10. Lin Teng –

    This company makes it very easy to buy in bulk. We really appreciate that and the fact that you have amazing stock

  11. Greg Fedorowski –

    They sent 2 Bac waters which was a nice surprise! Thanks!!

  12. Maggie Yuse –

    Everything was shipped overseas in one peice.

  13. Marty Quin –

    peptides work well and are great with my research. quality is top tier.

  14. tony pann –

    Was recommended to them from an old classmate. Needed a new peptide spot as mine raised their prices. I love the effects it is having on my research. I also love how great their CS is as they know the products they’re selling.

  15. roberta mand –

    The matto is excellent, and the company seems to constantly be looking out for the customer’s interests. The coupon codes they give out on a regular basis are fantastic! That is a bonus for me as well. Even when my purchase wasn’t very expensive, I noticed they would sometimes include a complimentary bottle of Bac water in the package.

  16. jarod buckley –

    When I called Danni, they were able to take my order for me. When I couldn’t figure out how to make the last payment, I decided to give them a call and see if I could get through to someone. I’m glad it wasn’t one of those computerized assistance systems.

  17. Mike Ritter –

    customer service and peptides are unmatched

  18. Efren Maldonado –

    Recomendé esta empresa a todos mis amigos.

  19. Josh Engle –

    My bacteriostatic water was missing from the package when it arrived, even though I met the minimum order, and when I reached out to them they apologized and sent me an express package with 2 bacteriostatic waters and one more vial of the peptide I ordered before.

  20. Jake Davenport –

    Best peptide company out there

  21. Tomas Calland –

    Like the blog updates every week! Nice, short, and to the point. Makes it easy to understand the peptide as well and what it’s best used for! Can find some good substitution options as well.

  22. Dave Picard –

    I once left a review saying I’d like to see more blends and here they are. I love that they take suggestions and make them happen. Big plus for me

  23. Kenny Blazon –

    I think their prices are just a bit on the high end, but I would recommend buying in batches

  24. Rod Kirsch –

    No DAC works better for what my research entails and I am very happy I have found a company that can supply this product in bulk with no issue

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