Mod GRF 1-29 (CJC-1295 NO DAC) (5mg)

(24 customer reviews)


Discount per Quantity

5 - 95%$36.10
10 +10%$34.20
SKU: Mod-GRF-1-29-5mg Category:


Modified GRF 1-29 5mg SPECIFICATIONS

AKA: Mod GRF (1-29)

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

PubChem: CID 56841945

CAS Number: 863288-34-0

Reconstitution: Required

What is Mod GRF (1-29) peptide?

Mod GRF (1-29) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It was first developed in the 1980s when studies revealed that the first 29 amino acids of GHRH possessed all of the biological roles associated with the full-length 44 residue protein. The initially designed peptide, known as GRF (1-29), is the shortest segment of GHRH, which has all the properties of the full-length hormone. A different truncated synthetic form of GHRH known as Sermorelin or GRF 1-29 also has 29 amino acids.
Modified GRF (1-29) undergoes alteration to include four substituted amino groups in its chain. These amino modifications protect the peptide from both oxidation and degradation during manufacture and transport and in vivo. The modification further increases the binding affinity to GHRH receptors.
Though GRF happens to be biologically potent like GHRH, the duration of action is restricted due to a short half-life (less than 10 minutes). As a result, researchers have modified it to enhance its half-life with better therapeutic potential. Modified GRF (1-29), also known as mod GRF or tetra-substituted GRF (1-29). The latter name clarifies that the modified peptide differs from GRF (1-29) as a result of changes in four of its amino acids. Modified GRF (1-29) is identical to CJC-1295 without DAC.


Modified GRF mediates the same biological effects as GHRH, including muscle growth (hypertrophy), improved bone development, enhanced lipolysis, accelerated metabolism, and wound healing. It also positively influences the immune system and blood sugar regulation.

Modified GRF and Cardiac Function
Research in rodent models has highlighted that modified GRF and other GHRH derivatives can improve the capacity of the heart to pump blood even after a heart attack. This could be of immense potential in improving the quality of life and reducing death over the long term in patients diagnosed with cardiac failure. Modified GRF has the potential to be effective in the treatment of pulmonary hypertension, cardiac failure, heart attack, and diverse congenital heart conditions.

Modified GRF and the Intestine
Early studies have highlighted that growth hormone (GH) is beneficial for Crohn’s disease, short bowel syndrome, and other inflammatory bowel conditions. Unfortunately, the adverse effects of long-term use exceed the benefits of the hormone. Thus, researchers have looked into GHRH analogs for mediating a similar effect. Research in monkeys indicates that mod GRF binds with vasoactive intestinal peptide (VIP) receptors and improves bowel motility, as improved bowel movement is crucial in inflammatory bowel diseases associated with constipation. The peptide happens to interact with VIPC1, present on the smooth muscle of the reproductive, gastrointestinal as well as urinary systems. These conditions trigger a great deal of morbidity and are difficult to address due to the lack of alternative drug options.

The Interaction between Thyroid Hormone and Growth Hormone
Malfunctioning of the thyroid gland is often associated with concomitant issues in GH release. Patients suffering from hypothyroidism have been treated with modified GF to prove the above hypothesis. It has been observed that individuals who receive the thyroid replacement hormone demonstrate stronger reactions to GRF, proving a link between thyroid hormone and GH. Thus, peptides like modified GRF may contribute towards a better understanding of human physiology.
Modified GRF exhibits milder side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage required in mice (per kg) does not scale to that suitable for humans.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

24 reviews for Mod GRF 1-29 (CJC-1295 NO DAC) (5mg)

  1. Gabriel Miller

    You get what you pay for. I had found antoher cheaper supplier but I think it was bunk. no effects whatsoever. The results were obvious with this product after ordering here/

  2. Noah White

    The website is easy to use, orders are easy to track, products arrived on time and everything was as it was promised to be

  3. Luca James

    Everything went very smoothly so far. I am very pleased with the experience

  4. Beckett Black

    This product is a Holy Grail

  5. Blake Rivera

    Everything was as expected

  6. Heather Watson

    Very transparent staff. I love it

  7. Rachel Wilkens

    The company I work for has researched a bunch of peptide companies over the years and as soon as BP came on the market, we gave it a shot and never switched suppliers again

  8. Ken Eberle

    Retrun time is great. Had an issue with payment and put the wrong payment method. Taylor was the one I was emailing with, they were able to fix that right up for me.

  9. Simon Cambell

    There’s some shitty quality stuff out there. Biotech’s peptides are not one of them.

  10. Lin Teng

    This company makes it very easy to buy in bulk. We really appreciate that and the fact that you have amazing stock

  11. Greg Fedorowski

    They sent 2 Bac waters which was a nice surprise! Thanks!!

  12. Maggie Yuse

    Everything was shipped overseas in one peice.

  13. Marty Quin

    peptides work well and are great with my research. quality is top tier.

  14. tony pann

    Was recommended to them from an old classmate. Needed a new peptide spot as mine raised their prices. I love the effects it is having on my research. I also love how great their CS is as they know the products they’re selling.

  15. roberta mand

    The matto is excellent, and the company seems to constantly be looking out for the customer’s interests. The coupon codes they give out on a regular basis are fantastic! That is a bonus for me as well. Even when my purchase wasn’t very expensive, I noticed they would sometimes include a complimentary bottle of Bac water in the package.

  16. jarod buckley

    When I called Danni, they were able to take my order for me. When I couldn’t figure out how to make the last payment, I decided to give them a call and see if I could get through to someone. I’m glad it wasn’t one of those computerized assistance systems.

  17. Mike Ritter

    customer service and peptides are unmatched

  18. Efren Maldonado

    Recomendé esta empresa a todos mis amigos.

  19. Josh Engle

    My bacteriostatic water was missing from the package when it arrived, even though I met the minimum order, and when I reached out to them they apologized and sent me an express package with 2 bacteriostatic waters and one more vial of the peptide I ordered before.

  20. Jake Davenport

    Best peptide company out there

  21. Tomas Calland

    Like the blog updates every week! Nice, short, and to the point. Makes it easy to understand the peptide as well and what it’s best used for! Can find some good substitution options as well.

  22. Dave Picard

    I once left a review saying I’d like to see more blends and here they are. I love that they take suggestions and make them happen. Big plus for me

  23. Kenny Blazon

    I think their prices are just a bit on the high end, but I would recommend buying in batches

  24. Rod Kirsch

    No DAC works better for what my research entails and I am very happy I have found a company that can supply this product in bulk with no issue

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