Comparing CJC-1295 and CJC-1295 with DAC Peptides

by | Apr 22, 2022 | Research

CJC-1295 is available in two forms: CJC-1295 and CJC-1295 DAC. CJC-1295 DAC is similar to CJC-1295 in structure but has a small motif added to it at the end.
This small addition has significant effects on how the two peptides work.

The most crucial difference it creates is its effects on the half-life of the peptide. This small change increases the half-life of CJC-1295 DAC by 6 to 8 days.


What is CJC-1295?

CJC-1295 has several names. It is also known as the ‘Modified GRF (1-29)’ or ‘Mod GRF 1-29‘. All these compounds refer to the same peptide compound. This peptide is smaller in structure compared to the original protein.

Mod GRF 1-29 is a synthetic substitute for Growth Hormone Releasing Hormone (GHRH). Due to its resemblance to GHRH, Mod GRF 1-29 can cause a significant increase in GH levels. Growth Hormone (GH) is a body hormone produced by the thalamus in the brain. It controls several body functions. These functions include glucose metabolism, lipid breakdown, bone health, skin health, and blood pressure regulation. Some other potential effects include preventing signs of aging and improving overall well-being.

The growth hormone levels do not remain constant as you age. Instead, they fluctuate with age. The levels are highest when you hit puberty. That’s why individuals experience a spurt of growth during puberty. After that, the growth hormone experiences a rapid decline. Its levels reach a significant low in the 50s and continue to decline further in the 60s.

Due to its ability to mimic the action of GHRH, the peptide can act on the growth hormone-releasing receptors of the brain. This receptor signals the brain to make more growth hormones. It is an effective strategy for increasing growth hormone levels. It is also effective in reversing the signs of growth hormone deficiency with increasing age.


What is CJC-1295 DAC?

As mentioned, CJC-1295 DAC has a structure similar to CJC-1295. The only difference is that it has a small addition called ‘Drug Affinity Complex (DAC)’ attached to the end of the peptide.

DAC consists of a few nitrogen and oxygen atoms. But this small change can significantly affect how the body treats CJC-1295 DAC compared to CJC-1295.


Differences Between CJC 1295 and CJC 1295 DAC

The main difference between the two molecules is the effect on half-life.
Mod GRF 1-29has a structure similar to the body’s GHRH. The half-life of the peptide is too short. It lasts only 30 minutes. This amount of time is a significant limitation.

CJC-1295 DAC, on the other hand, has a longer half-life. The DAC end of CJC-1295 allows it to bind to the albumin proteins.

This small addition to Mod GRF 1-29 causes a dramatic increase in its half-life. Compared to the CJC-1295 peptide, the half-life of CJC-1295 DAC is approximately 6 to 8 days.

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