KPV & it’s Potential Anti-Inflammatory Effects

by | Apr 25, 2022 | Research

What Is KPV?

KPV is the newest immunomodulating peptide to have emerged as a result of ongoing research. It is a peptide found in the body as a part of the hormone alpha-MSH. This C-terminal peptide derivative of the alpha-MSH has been tested for its photoprotective properties, owing to which it can protect against ischemia, inflammation, and hypoxic injuries. It is also said to have benefits in feeding and energy homeostasis mechanisms. The KPV peptide is made up of lysine-proline-valine subunits and is said to be a potential anti-inflammatory.

Its anti-inflammatory effect is very pronounced in the small intestines, where it has been investigated for its use in inflammatory bowel disease (IBD).

Apart from the small intestine, KPV peptide has also shown potent anti-inflammatory effects in the central nervous, vascular, GIT, and lungs.


KPV as an Anti-Inflammatory

Clinical data and analysis have suggested that KPV produces anti-inflammatory effects via different mechanisms.

KPV inactivates the inflammatory pathways inside the cells by directly interacting with the inflammatory signaling molecules that mediate the inflammatory response. It usually enters the nucleus, inactivates, and stops the inflammatory processes.

This process is the mechanism by which it exerts its anti-inflammatory effect in the gut. KPV can also stop the pro-inflammatory mechanisms in intestinal epithelial and cells responsible for immunity.

It can interact straight with immune cells, which can reduce inflammation. Research showed that KPV significantly decreased inflammation in colitis. It decreases the inflammatory response by inhibiting pro-inflammatory cytokine (molecule) synthesis and secretion. KPV may help in the case of IBDs through inhibited immune responses.


KPV Peptide As An Anti-microbial

Ongoing research has revealed that in addition to its anti-inflammatory effects, it also has some anti-microbial effects.
This anti-microbial activity is against two particular microbes. These pathogens are Staphylococcus Aureus and Candida Albicans. Studies showed that KPV  significantly inhibited the growth of S. aureus into colonies.


KPV Peptide In Wound Healing And Skin

Ongoing research has shown that KPV peptide can accelerate wound healing by reducing infection (anti-microbial) and fighting inflammation (anti-inflammatory).

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