KPV (4mg)

(14 customer reviews)

$39.00

KPV peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $37.05$35.10
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: KPV-4mg Category:

Description

KPV Peptide

KPV, the C-terminal peptide stretch of alpha-melanocyte-stimulating hormone (alpha-MSH), has been explored for its potential photoprotective characteristics, possible action against ischemia, and other consequences in feeding behavior, inflammation, and energy homeostasis.[1]

Specifications

Other Known Titles: MSH(11-13), ACTH(11-13), alpha-MSH(11-13)

Molecular Formula: C16H30N4O4

Molecular Weight: 342.43 g/mol

Sequence: Lys-Pro-Val

KPV Peptide Research

KPV Peptide and Intestinal Inflammation
The primary subject of KPV research has been focused on its potential for reducing intestinal inflammation. In mouse models of inflammatory bowel disease (IBD), it appeared to reduce inflammatory infiltrates, MPO activity, and overall histological evidence of inflammation. KPV appeared to help mice to recover faster and gain weight. Delivery of KPV using nanoparticles functionalized with hyaluronic acid appeared to help direct inflammation to targeted intestinal locations.[2] Thus the suppression of TNF-alpha may reduce inflammation and cause mucosal healing in mice. The researchers note that: “These results collectively demonstrate that our HA-KPV-NP/hydrogel system has the capacity to release HA-KPV-NPs in the colonic lumen and that these NPs subsequently penetrate into colitis tissues and enable KPV to be internalized into target cells, thereby alleviating ulcerative colitis.” Studies have suggested that the peptide also may reduce NF-kappaB and mitogen-activated protein kinase (MAPK) activity.[3] TNF-alpha, NF-kappaB, and MAPK inhibition together ameliorate the inflammatory changes in the intestine. Mice exposed to KPV appeared to exhibit less colonic infiltration and average colon lengths than the control group.

KPV Peptide and General Inflammation
Studies in rabbits dating back to 1984 posited that KPV may have anti-inflammatory and fever reducing (antipyretic) characteristics.[4] However, the peptide exhibited lower potency in these trials than the total length alpha-MSH molecule, suggesting that KPV lacked crucial sequences of alpha-MSH necessary for complete antipyretic activity. Researchers explored various analogs of alpha-MSH to reduce inflammation in a broad spectrum of diseases such as fever, irritant, allergic contact dermatitis, vasculitis, fibrosis, arthritis, and inflammation of the eyes, brain, lungs, and gastrointestinal tract.[5] The scientists reported that “This study indicates that KPV is transported into cells by PepT1 and might be a new [research] agent for IBD.”  The apparent anti-inflammatory impact of KPV may differ from alpha-MSH only marginally. The parent molecule is suggested to be better at suppressing late inflammatory responses, indicating that it might be influencing immune modulation, which is separate from immediate inflammatory responses only marginally. Wound healing is a complex process that involves three general phases in the wound healing process: inflammatory, proliferative, and remodeling. Most of these cells involved in wound healing express a Melanocortin 1 receptor (MC1R) that binds alpha-melanocyte-stimulating hormone and analogs like KPV and KdPT. KVP peptide researchers found that the peptide appeared to reduce the inflammatory properties without inducing the pigmentation associated with natural scar formation in the study setting. KPV may have both anti-inflammatory and anti-microbial activities. It appears to inhibit the growth of both Candida albicans and Staphylococcus aureus and may prevent infection in the setting of severe wounds like burns.

KPV Peptide and Scar Formation
KPV may decrease chronic inflammation, which appears to lead to hypertrophic scarring (e.g., keloid).[6] Hypertrophic scarring is considered to be caused by widespread macrophage infiltration, TNF immunoreactivity, and neutrophil abundance. Use of alpha-MSH in this setting may induce comparatively more minor scars and a less of an harsh inflammatory response. In comparison to related hormones, Alpha-MSH appears to exhibit greater potential impact than KPV but researchers posit that the molecule may have one serious disadvantage to KPV, inducing an increase in melanin production and pigmentation along the skin surface. The possible anti-inflammatory effects of KPV are mediated through a different pathway compared to those of alpha-MSH. Whereas alpha-MSH binds to specific melanocortin receptors, KPV does not appear to.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Elliott RJ, Szabo M, Wagner MJ, Kemp EH, MacNeil S, Haycock JW. alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells. J Invest Dermatol. 2004 Apr;122(4):1010-9. doi: 10.1111/j.0022-202X.2004.22404.x. PMID: 15102092.
  2. Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804.
  3. Zhu W, Ren L, Zhang L, Qiao Q, Farooq MZ, Xu Q. The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation. Mediators Inflamm. 2020 Sep 9;2020:6817156. doi: 10.1155/2020/6817156. PMID: 32963495; PMCID: PMC7499337.
  4. Richards DB, Lipton JM. Effect of alpha-MSH 11-13 (lysine-proline-valine) on fever in the rabbit. Peptides. 1984 Jul-Aug;5(4):815-7. doi: 10.1016/0196-9781(84)90027-5. PMID: 6333677.
  5. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008 Jan;134(1):166-78. doi: 10.1053/j.gastro.2007.10.026. Epub 2007 Oct 17. PMID: 18061177; PMCID: PMC2431115.
  6. Song J, Li X, Li J. Emerging evidence for the roles of peptide in hypertrophic scar. Life Sci. 2020 Jan 15;241:117174. doi: 10.1016/j.lfs.2019.117174. Epub 2019 Dec 13. PMID: 31843531.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

14 reviews for KPV (4mg)

  1. Alex Ranaudo

    Before doing business with a company, I prefer to conduct some research on them. So far, I’d give Biotech Peptides my highest recommendation to any researcher or business!

  2. PORTER BLACK

    When I’ve purchased from Biotech Peptides in the past, they’ve always been on time! You’ll also get SMS message notifications on your purchase.

  3. Darron Ashley

    Bacteriostatic water is pretty good quality! They even sent me 2 instead of one once!

  4. Jimmy D

    It’s a breeze from start to finish. All I have to do to check out is click a couple buttons and all my information is already stored. This is a pain in the neck at times, but I also like that I can see what I’ve previously purchased.

  5. R. Fulper

    Great quality peptide, lasted a while and I was able to use it for multiple experiments.

  6. Rattan Sharma

    Ordered a few of days ago. Earlier today, I received an email from their representative informing me that they are now sold out but would have more in stock shortly. Having to deal with it is a little irritating. I’m happy someone was able to contact me rather than leaving me to worry what happened to my purchase.

  7. Bryan Hu

    As always, great service and peptides speak for themselves.

  8. Shaun McSean

    Never had any issues with them. They always deliver great products on time

  9. Elise Tobias

    The shelf life on these peptides is amazing. You can buy in bulk and not worry about the peptides losing their properties, because they preserve really well

  10. Leon Valverde

    Muy buenos péptidos. Estoy muy satisfecho con el servicio aquí.

  11. Richie Newman

    All the researchers I know buying from here is highly pleased

  12. Anothony Anitsky

    Nice selection of Peptides. legit company with decent quality stuff as well.

  13. Lawrence Micheals

    The process of ordering from them is so easy and headache-free. Very easy to use site and standard check out process. Do wish they took apple pay however.

  14. Zac Weston

    There are very few companies online selling KPV and most of them are questionable. I am glad to have found Biotech and I can honestly say it is worth the investment

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