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KPV Peptide – The Newest Anti-Inflammatory Peptide
What Is KPV Peptide?
KPV is the newest immunomodulating peptide to have emerged as a result of the ongoing research on peptides and their uses. It is a peptide found in the body as a part of the hormone alpha-MSH. This C-terminal peptide derivative of the alpha-MSH has been tested for its photoprotective properties, owing to which it can protect against ischemia, inflammation, and hypoxic injuries. It is also said to have benefits in feeding and energy homeostasis mechanisms. The KPV peptide is made up of lysine-proline-valine subunits and is said to be an extremely potent anti-inflammatory.
Its anti-inflammatory effect is very pronounced in the small intestines, where it has been investigated for its use in inflammatory bowel disease (IBD).
Apart from the small intestine, KPV peptide has also shown potent anti-inflammatory effects in the central nervous system, vascular system, GIT, and lungs.
KPV Peptide As An Anti-Inflammatory
Clinical data and analysis have suggested that KPV produces anti-inflammatory effects via different mechanisms.
KPV peptide inactivates the inflammatory pathways inside the cells by directly interacting with the inflammatory signaling molecules that mediate the inflammatory response. It usually enters the nucleus, inactivates, and stops the inflammatory processes.
This process is the mechanism by which it exerts its anti-inflammatory effect in the gut. KPV can stop the pro-inflammatory mechanisms in intestinal epithelial and cells responsible for immunity.
It can interact straight with immune cells, which can reduce inflammation. KPV significantly decreased inflammation in colitis. It decreases the inflammatory response by inhibiting pro-inflammatory cytokine (molecule) synthesis and secretion. KPV may help in the case of IBDs through inhibited immune responses.
When taken via the oral route, KPV reduces the concentration of the pro-inflammatory cytokines. This decrease reduces colitis.
KPV Peptide As An Anti-microbial
Some ongoing research on the KPV peptide revealed that in addition to its anti-inflammatory effects, it also has some anti-microbial activity.
This anti-microbial activity is against two particular microbes. These pathogens are Staphylococcus Aureus and Candida Albicans. Studies showed that KPV peptide use significantly inhibited the growth of S.aureus into colonies.
Its anti-inflammatory and anti-microbial activity make it a potent agent in combating these pathogens and wound healing.
KPV Peptide In Wound Healing And Skin
Ongoing research has shown that KPV peptide accelerates wound healing by reducing infection (anti-microbial) and fighting inflammation (anti-inflammatory).
This process leads to overall better cosmetic results because scar formation reduces.
The KPV peptide can treat some very severe injuries, such as burn injuries. Producing effects at a physiologic concentration.
KPV can reduce inflammation that leads to hypertrophic scar (keloid) apparition. Using KPV (a-MSH) in this setting leads to more minor scars and less inflammatory action. Some of the benefits of reducing scar prominence appear to come from its ability to modulate collagen metabolism.
Clinical data from individuals with psoriasis, a skin disease that causes red, itchy, scaly patches, most commonly on the knees, elbows, trunk, and scalp, has shown some beneficial effects of KPV peptide. Its anti-inflammatory and anti-microbial properties are very marked in this condition.
This auto-immune condition, usually treated by steroid therapy, can be very effective and treated by the KPV peptide. It reduces the itchiness, dryness, redness, and peeling of the skin without long-term steroid therapy side effects.
Clinical Applications Of KPV Peptide
It finds its use in the following clinical settings:
● It is helpful in the treatment of eczema and acne
● It is helpful to reduce the symptoms of psoriasis on the skin
● It has been used in the treatment of ulcerative colitis
● It has been used in the treatment of inflammatory bowel disease
● It has been used in the treatment of Crohn’s Disease
● It is helpful to treat a wide variety of inflammatory conditions
● It is helpful to strengthen the immune system
● It is helpful as an anti-microbial
● It is helpful to improve skin health
● It is helpful in healing wounds & injuries
KPV is a potent anti-inflammatory peptide that can help many conditions. Most of the research involved IBD treatment (irritable bowel disease), where results have been very positive. KPV is safe when administered orally, subcutaneously, and topically. KPV is an organically derived peptide without any notable side effects. Research has shown that KPV offers many benefits that speed up wound healing, reduce infection, and fight inflammation.
Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.