PTD-BDM Research in Hair Follicle Regeneration

by | Apr 27, 2022 | Research

What Is PTD-DBM?

PTD-DBM peptide, or Protein Transduction Domain-fused Dishevelled Binding Motif, is the newest peptide in a series of similar groundbreaking discoveries. It is an artificial peptide that significantly affects hair follicle growth. It is under investigation as a potent anti-hair loss peptide.
Apart from its hair growth-stimulating properties, it can also improve wound healing.


How Was PTD-DBM Peptide Discovered?

In South Korea, research was conducted on a condition called androgenetic alopecia. It is one of the most common types of hair loss in both men and women. It is also more commonly known as pattern baldness. Professor Choi Kang-yeol of Yonsei University and his team of researchers discovered a protein linked to the hair loss that occurred in androgenetic alopecia. The protein was named CXXC5. This discovery led the team to discover the PTD-DBM peptide, which directly interacted with this protein to change the disease’s hair-loss mechanism. It also indirectly promoted hair follicle growth in lab mice treated with the peptide.


Mechanism Of Action – How It Promotes Hair Growth

PTD-DBM peptide mainly works by interfering with an endogenous protein, CXXC5, which is involved in the hair-loss mechanism.

CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway. This method is the main pathway involved in wound healing and hair regeneration. Typically, the protein CXXC5 binds to a protein called the Dishevelled protein and prevents the growth of hair follicles. Consequently, this can lead to hair loss and the inability to grow new hair.

This stage is where the peptide PTD-DBM peptide comes in. It is an activator of the Wnt/β-catenin pathway. This activation comes from interfering with the binding of CXXC5 with the Dishevelled (Dvl) protein. When applied topically, PTD-DBM can promote the growth of new hair follicles. It also inhibits the loss of existing hair. In addition, one of its other significant and valuable properties is its ability to cause wound repair by wound-induced hair neogenesis (WIHN).


Role Of PTD-DBM Peptide In Wound-Healing

The Wnt/β-catenin pathway is common between cutaneous wound healing, dermal fibrosis, and hair regrowth.

CXXC-type zinc finger protein 5 (CXXC5) is a negative feedback regulator of the Wnt/β-catenin way by interacting with the Dishevelled (Dvl) protein. The peptide reduced the CXXC5 protein levels in humans’ epidermal keratinocytes and dermal fibroblasts of acute wounds.

Since PTD-DBM peptide is the common link between the protein CXXC5 and the Wnt/β-catenin pathway, its role in regulating the pathway has been thoroughly investigated. Experiments on laboratory mice showed that inhibiting the CXXC5 protein leads to accelerated cutaneous wound healing and enhanced keratin 14 and collagen synthesis.

The PTD-DBM peptide links with the protein CXXC5 and interferes with regulating the Wnt/β-catenin pathway. This interaction brings about the wound-healing properties of the peptide.

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