PTD-DBM (5mg)

(9 customer reviews)


PTD-DBM peptides are Synthesized and Lyophilized in the USA.

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PTD-DBM Peptide

PTD-DBM stands for Protein Transduction Domain-fused Disheveled Binding Motif. It is a synthetic peptide which has been studied within a wide range of research areas, including tissue damage, hair follicle development. Researchers have focused on the peptide specifically within the context of follicle development, suggested it may exert stimulating action through interaction with the endogenous proteins linked to follicle damage, CXXC5.[1] It was discovered by Professor Kang-Yell Choi and his team of researchers at the Yonsei University in South Korea. The researchers studied the mechanism of hair follicle loss, and suggested that the cellular pathway Wnt/β-catenin may be crucial for follicle development. The signaling modulated by this pathway appears to control hair morphogenesis, growth, and regeneration.


Molecular Formula: C124H22N61O28S2

Molecular Weight: 3082.65

Sequence: H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys-OH

PTD-DBM Research

PTD-DBM Peptide and Androgenetic Alopecia
Hair follicle growth is considered to occurs in three phases, anagen phase (growth phase), catagen phase (regression phase), and telogen phase (resting phase).The excessive secretion of androgens such as testosterone, may lead to a shorter duration of the anagen phase. In research models of androgenetic alopecia, Wnt/β-catenin signaling appears to be primary among several cellular pathways involved in hair follicle development. This signaling pathway starts with the secretion of Wnt proteins.[2] These proteins appear to bind with the Low-Density Lipoprotein-Related Protein (LRP), which, in turn, may deactivate glycogen synthase kinase-3β (GSK-3β). GSK-3β is an enzyme that is considered to deactivate the β-catenin in the hair follicle. Once stabilized, β-catenin appears to bind with the T-cell factor (TCF)/lymphoid enhancer factor (LEF). The proteins generated by the activation of β-catenin-TCF/LEF are considered to lead to the regulation of hair follicle cellular proliferation.

While in the course of their research, Professor Kang-Yell Choi and team consistently reported that a specific protein called CXXC-type zinc finger protein 5 (CXXC5) appeared to be excessively expressed research models of alopecia. CXXC5 appears to trigger the signaling pathways leading to a downregulation of Wnt/β-catenin. This observation has been confirmed by ancillary studies where murine models not expressing CXXC5 did not exhibit baldness or patching.[3] CXXC5 appears to act by binding with another type of protein called Dvl protein. The CXXC5 and Dvl Protein-Protein Interaction (PPI) may lead to the downregulation of the Wnt/β-catenin pathway. As the Wnt/β-catenin pathway becomes downregulated, it may interfere with the generation of new hair follicles and the growth of existing ones. Based on the findings in various scientific studies, PTD-DBM is assumed to interfere with CXXC5 and Dvl Protein to Protein Interaction (PPI). It may lead to increased growth of hair follicles and due to this interaction, the hair follicles spend more time in the anagen phase of the hair cycle. The action of PTD-DBM appears to be further enhanced when symbiotically combined as with the case of valproic acid.

PTD-DBM Peptide and Tissue Repair
The Wnt/β-catenin pathway is considered to play a crucial role in tissue repair and the fibrosis of skin breaks. One of the regulators of this pathway is CXXC-type zinc finger protein 5 (CXXC5). It appears to function by negative feedback regulation. CXXC5 interacts with the Disheveled (Dvl) protein and downregulates the action of the Wnt/β-catenin signaling pathway.[4] The researchers conclude that “these data suggest that CXXC5 would represent a potential target for future therapies aimed at improving wound healing.” The CXXC5−/−knockout mice examined in the quoted research study exhibited reportedly accelerated healing of skin lesions. They also exhibit increased keratin and collagen synthesis. PTD-DBM may exhibit the potential to function in a preventative action of the CXXC5-Dvl domain. It has been noted by researchers to enact this potential by preventing the Protein-Protein Interaction (PPI) between CXXC5 and Dvl proteins. This may result in an upregulation of the Wnt/β-catenin pathway. This upregulation may lead to hastened tissue repair processes through increasing keratin and collagen synthesis and by accelerating dermal fibrosis.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017 Nov;137(11):2260-2269. doi: 10.1016/j.jid.2017.04.038. Epub 2017 Jun 6. PMID: 28595998.
  2. Kim D, Garza LA. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled. J Invest Dermatol. 2017 Nov;137(11):2248-2250. doi: 10.1016/j.jid.2017.07.826. Epub 2017 Sep 27. PMID: 28967390; PMCID: PMC6399733.
  3. Ryu, Y.C.; Park, J.; Kim, Y.-R.; Choi, S.; Kim, G.-U.; Kim, E.; Hwang, Y.; Kim, H.; Han, G.; Lee, S.-H.; Choi, K.-Y. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells 2023, 12, 555. doi: 10.3390/cells12040555.
  4. Lee SH, Kim MY, Kim HY, Lee YM, Kim H, Nam KA, Roh MR, Min do S, Chung KY, Choi KY. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. J Exp Med. 2015 Jun 29;212(7):1061-80. doi: 10.1084/jem.20141601. Epub 2015 Jun 8. PMID: 26056233; PMCID: PMC4493411.
  5. Ryu YC, Lee DH, Shim J, Park J, Kim YR, Choi S, Bak SS, Sung YK, Lee SH, Choi KY. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021 Jun;178(12):2533-2546. doi: 10.1111/bph.15438. Epub 2021 May 5. PMID: 33751552; PMCID: PMC8251890.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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Biotech Peptides

9 reviews for PTD-DBM (5mg)

  1. dan waller

    Big fan of the company and their quality of peptide. I also enjoy reading the blogs they post. Every few days there’s a new topic of interest with connections to peptides and as someone who is also a professor I have my students read it as well just to get a quick read of the topic (only if it connects to the lesson of course!)

  2. Julian Price

    Biotech does have some good quality peptides. I go back and forth between them and a few other places but I do see myself purchasing more and more at Biotech than anywhere else.

  3. Diego Santiago

    Les doy cinco estrellas. Estoy muy impresionado con sus productos y servicios.

  4. Heather Bowen

    I ordered from them as our lab has listed a few websites they trust to get peptides from. They are one of them.

  5. Kyle rhodes

    Their customer service is phenomenal. Jaimie was knowledgeable on peptides and was able to let me know about a substitue peptide for the one I needed that was out of stock at the moment. Great exeprince.

  6. Ryan P.

    Nothing short of excellent service and peptides.

  7. Chris Costa

    Quality checks out, peptides did wonder for my research.

  8. Kim Catalan

    Peptide quality is fantastic! They also have good shelf life so one order last me a while since my projects don’t require a high dosage.

  9. Gary Hopper

    I had an issue with payment as I used the wrong card they had on file. Sent a quick email to their rep and Taylor responded within 10 minutes. They were able to make the changes and answered a few questions I had about the storage and if there was any sales coming up.

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