What Is PTD-DBM Peptide?
PTD-DBM peptide, or Protein Transduction Domain-fused Dishevelled Binding Motif, is the newest peptide in a series of other similar ground-breaking discoveries. It is an artificial peptide that significantly affects hair follicle growth. It is under investigation as a potent anti-hair loss peptide.
Apart from its hair growth stimulating properties, it also improves wound healing.
How Was PTD-DBM Peptide Discovered?
In South Korea, research was conducted on a condition called androgenetic alopecia. It is one of the most common types of hair loss in both men and women. It is also more commonly known as pattern baldness. Professor Choi Kang-yeol of Yonsei University and his team of researchers discovered a protein linked to the hair loss that occurred in androgenetic alopecia. The protein was named CXXC5. This discovery led the team to discover the PTD-DBM peptide, which directly interacted with this protein to bring about changes in the hair loss mechanism of the disease. It also indirectly promoted hair follicle growth in lab mice treated with the peptide.
Mechanism Of Action – How It Promotes Hair Growth
PTD-DBM peptide mainly works by interfering with an endogenous protein, CXXC5, which is involved in the hair-loss mechanism.
CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway. This method is the main pathway involved in wound healing and hair regeneration. Typically, the protein CXXC5 binds to a protein called the Dishevelled protein and prevents the growth of hair follicles. Consequently, this leads to hair loss and the inability to grow new hair.
This stage is where the peptide PTD-DBM peptide comes in. It is an activator of the Wnt/β-catenin pathway. This activation comes from its interference with the binding of CXXC5 with the Dishevelled (Dvl) protein. When applied topically, PTD-DBM peptide promotes the growth of new hair follicles. It also inhibits the loss of already grown hair. In addition, one of its other significant and valuable properties is its ability to cause wound repair by the process of wound-induced hair neogenesis (WIHN).
Role Of PTD-DBM Peptide In Wound-Healing
The Wnt/β-catenin pathway is common between cutaneous wound healing, dermal fibrosis, and hair regrowth.
CXXC-type zinc finger protein 5 (CXXC5) serves as a negative feedback regulator of the Wnt/β-catenin way by interacting with the Dishevelled (Dvl) protein. The peptide reduced the CXXC5 protein levels in humans’ epidermal keratinocytes and dermal fibroblasts of acute wounds.
Since PTD-DBM peptide is the common link between the protein CXXC5 and the Wnt/β-catenin pathway, its role in regulating the pathway has been thoroughly investigated. Experiments on laboratory mice showed that the inhibition of the CXXC5 protein leads to accelerated cutaneous wound healing and enhanced keratin 14 and collagen synthesis.
The peptide PTD-DBM peptide links with the protein CXXC5 and interferes with regulating the Wnt/β-catenin pathway. This interaction brings about the wound healing action of the peptide.
PTD-DBM Peptide and Valproic Acid
Studies have proven that PTD-DBM peptide is significantly more effective at inducing hair neogenesis when combined with Valproic Acid, which stimulates the Wnt/β-catenin pathway when applied topically. Using this combination post-micro needling is recommended to take advantage of the follicle development induced naturally by the wound healing process.
Both these compounds improve hair follicle growth, reduce hair loss, and have other beneficial effects when used in combination. These include anti-seizure properties, preventing hair loss, alleviating pain in patients with migraine, mood enhancement, sharpening focus by improving cognitive function, and accelerating wound healing and repair.
Clinical Applications Of PTD-DBM Peptide
● Treatment of Pattern Baldness
This disease, which occurs due to genetics and decreasing levels of androgens in the body, is a common condition in women and men. It presents with a pattern of hair loss over the scalp and diffuses thinning of hair.
The search for a successful anti-hair loss drug has continued for quite a long time. The discovery of the peptide PTD-DBM peptide proved to be a breakthrough. This breakthrough is because the peptide prevents hair loss and promotes the growth of new hair follicles.
● Scalp Skin Repair in Bald Men and Women
Due to its wound healing properties, PTD-DBM peptide has also been investigated to repair scalp skin subjected to hair loss.
● Hair Regrowth
One of the reasons why PTD-DBM peptide is such a breakthrough in hair loss drugs is that it also stimulates the growth of newer hair follicles. So, it prevents hair loss and promotes new hair growth.
● Acceleration of Wound Healing
By activating the Wnt/β-catenin pathway, the PTD-DBM peptide induces hair regrowth and wound-induced hair neogenesis (WIHN).
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