AHK-cu, often termed ‘copper AHK,’ is a peptide with an associative (chemically related to) copper ion attached to it. It is a dermal (endothelial) growth stimulant and anti-aging peptide. It is found in the bloodstreams of mammals and is vital in regulating the development, growth, and death of vascular endothelial cells—cells that line the inner wall of blood vessels. The mentioned effects of AHK-cu are because of its ability to enhance the production of a growth peptide termed the Vascular Endothelial Growth Factor (VEGF).

This peptide is of interest to researchers and is studied extensively because of its ability to improve hair growth and prevent aging effects on the skin. Due to its various effects on the skin, it is now being extensively investigated as an anti-aging agent.

According to research, the primary interest is AHK-cu’s effect on fibroblasts – cells responsible for the growth and maintenance of extracellular matrix.

The Benefits of AHK-cu (Topical)

The market value for hair loss and anti-aging products is worth trillions of dollars. Therefore, researchers keep digging in search of new ways to reverse the effects of aging and hair loss. A peptide without side effects would be as treasurable as gold with boundless potential in this terrain.

According to research, AHK-cu could be beneficial in the following areas:
● Hair Loss: AHK-cu impacts hair loss in two ways. First, it improves the growth of blood vessels by enhancing the secretion of VEGF. Second, it down-regulates the action of TGF beta-1. Blood vessels and enhanced blood flow to the scalp are necessary for supplying vital nutrients to hair follicles. AHK-cu’s research on animal models shows that its effects are not limited to the increase of blood flow to existing hair follicles, as it bolsters the growth of new hair follicles by promoting the growth of blood vessels.
Dihydrotestosterone is the hormone responsible for the development of male characteristics along with the uprise of male pattern baldness and thinning hair in both women and men as they age. The effects of DHT are via the action of TGF beta-1. Therefore, the down-regulation of TGF beta-1 can allow for the direct reduction of DHT by AHK-cu. Subsequently, protecting hair follicles from adverse stress.
● Hair Growth Stimulation: AHK-cu can improve hair growth, causing the hair to become longer, stronger and thicker. Hair follicles go through three stages of development – anagen, catagen, and telogen. The anagen stage is the active stage of hair growth that anteces the catagen and telogen. This stage of development is notable via brisk division and differentiation. Research shows that AHK-cu can help hair follicles remain in the anagen stage and retain strands in the anagen stage for about 3-5 years.
● Reduction of Wrinkles and the Anti-aging effect: Copper peptides and copper are potent ancillaries in skin and sunscreen creams. AHK-cu research in animal models shows that it is a remarkable stimulant of collagen synthesis. Collagen has lots of benefits for the skin—it gives structure to the skin, strengthens the skin, and enhances its elasticity and hydration. These effects of collagen help reduce the emergence of lines and wrinkles. The key point is that AHK-cu can reduce the emergence of wrinkles in animal models.

The aging of the skin results in the rapid deterioration in the number of fibroblasts. This causes a reduction in the amount of elastin and collagen in the skin, allowing for the emergence of aging—characterized by saggy skin, wrinkles, crow’s feet, harsh texture, and tone.

The administration of AHK-cu can help counteract the aging signs by stimulating the growth and development of new fibroblasts. Through its effect on TGF beta-1 and VEGF, AHK-cu activates the replication and development of body cells termed fibroblasts. The abundance of fibroblasts in the skin will usher in an increase in collagen and elastin. AHK-cu, according to research, stirs up the production of Type 1 collagen by 300%.


AHK-cu shows promising results regarding the growth of fibroblasts and endothelial cells. According to research, it is also a potent anti-aging peptide.

However, extensive research is still ongoing in animal and laboratory models by cosmeceutical industries to further ascertain a wide range of AHK-cu’s abilities and their effects on skin health, collagen synthesis, and hair growth.

Despite the eye-catching benefits accompanying the AHK-cu peptide, it is limited to educational and scientific purposes, and not for human consumption.Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

Role of Copper Peptide in the Improvement of the Growth of Hair Follicle

Copper Peptide is formed as a result of the affinity of the human peptide, GHK (glycyl-L-histidyl-L-lysine), to the Cu(2+) (Copper 2+). In the human body, the Copper Peptide has varied roles like collagen stimulation, anti-inflammatory, anti-oxidant effects, enhancing...

The Benefits of Epitalon in Anti-Aging and Cell Health

Epitalon is a peptide that has been majorly studied for its anti-aging influence. The findings have been restricted to animal studies. Hence the efficacy of the molecule in humans is subject to conjecture. The molecule has been shown to reverse the aging process...

Unique Effects of Sermorelin in Regulating Sleep

What is Sermorelin peptide? Sermorelin peptide is a synthetic analog of the naturally occurring growth hormone-releasing hormone (GHRH). GHRH is a 44 amino acid long peptide, and Sermorelin peptide comprises the first 29 amino acids. The shortened peptide is...