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AHK-Cu (topical) (200mg)
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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What Is AHK-Cu Peptide?
AHK-Cu is a tripeptide that contains a copper atom linked with iron. It is a short peptide in which the copper atom is attached between the histidine and alanine residues of the alanine-histidine-lysine tripeptide. The copper atom is linked to three nitrogen atoms in this molecule.
It is found in the blood of most mammals. It is significantly valuable in growth regulation, death, and vascular endothelial cells (these are the cells that make the innermost layer of blood vessels). AHK-Cu has been studied extensively in laboratory models and animals because of its role in hair growth, effects on skin health, collagen synthesis, and hair loss prevention.
It regulates various cellular processes primarily by controlling the production of two compounds: Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor beta (TGF-B). AHK-Cu, by enhancing levels of the Vascular Endothelial Growth Factor, activates fibroblasts and endothelial cells. Fibroblasts lead to the production of two complex compounds; elastin and collagen. These two molecules affect skin texture, tone, and elasticity.
Endothelial cells are responsible for the growth and health of blood vessels that supply nutrition to hair follicles and skin cells. The activation of endothelial cells in association with the fibroblasts leads to reduced fine lines and wrinkles and increased skin elasticity, and improved wound healing. Some laboratory studies done on human skin cells indicated an increase in collagen type 1 production to the extent of as much as 300%. It is quite promising and reassuring for the future applications of AHK-Cu in anti-aging skin-care products.
MOLECULAR FORMULA: C15H25CuN6O4
MOLECULAR WEIGHT: 416.9 g/mol
RESEARCH IMPLICATIONS OF AHK-Cu
AHK-Cu has been of great interest to researchers due to its ability to promote hair growth and slow down the effects of aging on skin and hair. AHK-Cu primarily plays its role by its effect on fibroblasts. These cells function in maintaining and growing the Extracellular Matrix (ECM), which surrounds the cells. Fibroblasts secrete various biological substances, such as Vascular Endothelial Growth Factor (VEGF). These factors lead to the formation of new blood vessels. Because of these attributes, AHK-Cu has been studied extensively by cosmeceutical industries to bring them to use in anti-aging formulations.
ROLE OF AHK-Cu IN THE REDUCTION OF WRINKLES
Copper and its peptide derivates are often used in the formulation of skin creams and sunscreens because of their role in enhancing collagen production. A decline in the skin levels of collagen is the hallmark of the aging process. The body stops producing more collagen with increasing age, and the existing collagen reduces its structural and functional integrity.
Collagen affects the skin in several ways, such as providing structure by making it tauter. Also, it has an affinity for water, so it hydrates the skin cells and the extracellular matrix when it enters the skin.These properties of collagen reduce the appearance of wrinkles and fine lines of the skin. This attribute helps in improving the appearance of sagging skin.
Several scientific studies have shown the effect of AHK-Cu in skin conditioning and making it look younger and healthier.
ROLE OF AHK-Cu IN HAIR LOSS AND HAIR GROWTH
AHK-Cu controls hair loss by two mechanisms. First, it stimulates the secretion of the Vascular Endothelial Growth Factor and leads to the growth of blood vessels in the area surrounding the hair follicles. These blood vessels supply nutrition to hair follicles and promote hair growth. A reduction in the supply of these nutrients, on the other hand, leads to hair loss. Studies have shown that AHK-Cu can also lead to the formation of new hair follicles by promoting new blood vessels and improving blood supply to existing hair follicles. By stimulating the growth of blood vessels, AHK-Cu keeps the hair healthy, strong, and long.
The second mechanism by which AHK-Cu prevents hair loss is down-regulating Transforming Growth Factor beta. This reduces the effect of dihydrotestosterone (DHT) on hair loss. Dihydrosterone is the hormone primarily responsible for male pattern baldness and progressive hair-thinning in both men and women as they age. Reducing the effect of dihydropteroate can prevent hair loss by protecting the hair follicles from negative stress.
By increasing the blood supply to an existing follicle, AHK-Cu increases its size and enhances hair thickness. And this leads to stronger hair.
Studies also show that AHK-Cu can extend the hair growth phase. Generally, the hair growth cycle has 3 phases: Anagen, telogen, and catagen phase. Among these, AHK-Cu both extends and triggers anagen hair growth phase, lasting for 3-5 years. This prolongs the lifespan of hair and reduces hair fall.
It is an interesting tripeptide with profound benefits in slowing down age-related progressively degenerating changes, specifically in hair and skin. The results shown by research in the laboratories are promising. It is expected that soon AHK-Cu will be made available as an over-the-counter anti-aging topical treatment. Researchers consider it a virtually side-effect-free product.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.