Vilon: Promising Research and Anti-Aging

by | Jul 29, 2022 | Research

Vilon is an immunomodulatory and anti-aging peptide bioregulator. It can increase the anti-aging effect vital for longevity when administered early in life.

Vilon peptide also reduces and prevents the prevalence/risk of cancer development and succession. Vilon research has also indicated that the peptide can modulate the vascular system and improve hemostasis.

How Vilon May Influence Cancer:

One of Villon’s potential functions is the reduction of cancer prevalence. However, Vilon action results show that the peptide may reduces cance incidence and can potentially prevent cancer progression in cancer patients.[1] Vilon can be considered both a potent chemotherapeutic agent and potent addition to the arsenal for cancer treatment and surgery due to this effect.[2] Researchers note that “Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media.”

It is important to note that the Vilon is still under review to see if its efficacy against cancer is beneficial when administered alone or in combination with other anticancer regimens. 


The Benefits of Vilon in Aging:

Vilon is a potent anti-aging peptide.[3] It may boost physical activities and endurance. Consequent to these Vilon peptide effects, lifespan is extended.

The anti-aging effect of the Vilon peptide extends to the gastrointestinal tract (GI tract). Here, the peptide enhances enzyme activity in the GI tract. Vilon also increases barrier function, thereby decreasing the development of leaky gut, improving disease resistance, and bettering the overall GI tract health. The peptide also increases the absorption of glucose and glycine in the small intestine.[5] The researchers note that “Vilon stimulated active glucose accumulation in the serous sac of the medial small intestine.”


The Function of Vilon in the Immune System:

Vilon peptide is an effective modulator of chromatin structure. The following are related functions: the peptide induces unrolling of chromatin, activates synthetic processes by reactivating ribosomal genes in the unrolled chromatin, releases repressed genes, and does not induce the decondensation of pericentromeric chromatin structure.

The overall benefits of these functions scale down to the reactivation of genes in the DNA that are silent.

Chromatin exists in two states: wound (heterochromatin) and unwound (euchromatin).[6] The apparatus that converts genes into proteins and functional components of the cell cannot access the heterochromatin state. Genes in these DNA regions are unavailable for protein production in general.

Chromatin also modulates the genes available for transcription, and it is a way that different cells or the same cells can have varying functions over a period. Chromatin condensation is one of the causes of aging and senescence and why tissues lose functions with age. The ability of the peptide to reactivate these cells by heterochromatin unraveling can restore immune function in the elderly.[7] The result is evident in lymphocytes—white blood cells of the immune system like the killer cells, T cells, and B cells that produce antibodies and coordinate immune response to pathogens such as cancer.

The peptide also activates interleukin-2 signaling in splenocytes coupled with Vilon activity in lymphocytes. There is protection against microbial infections, and natural protection against autoimmune reactions, due to the activation of splenocytes and lymphocytes.

Vilon plays a role in the thymus, where it increases CD5 T-cell proliferation. CD5 T-cells and cytotoxic CD8 T-cells are a marker of mature T-helper cells. CD8 T-cells are anti-microbial cells, and CD5 T-cells regulate the immune system and prevent autoimmune reactions in the body.

In a nutshell, the Vilon peptide only rejuvenates immune functions by reactivating genes that are silent by chromatin changes. It cannot reactivate genes that are naturally silent in the affected cells. Vilon enhances the immune system while it prevents autoimmune reactions. 


The Functions of Vilon Peptide in the Heart and Kidney:

Scientists believe that Vilon is beneficial in the vascular system. However, this is not well studied and does not have enough results to support this notion. Nonetheless, the Vilon peptide modulates the expression of 36 and more different genes in the heart. When added to Epithalon, the number jumps to 144 genes.

In the kidney, Vilon may reduce transforming growth factor-beta-1 concentration and the micro vessel permeability.

Patients with diabetes exhibited optimized coagulation on the administration of Vilon. The peptide increases natural anticoagulant antithrombin III levels and Protein C while enhancing fibrinolysis.

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  1. Khavinson VKh, Anisimov VN. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits growth of spontaneous tumors and increases life span of mice. Dokl Biol Sci. 2000;372:261-263.
  2. Barykina OP, Iuzhakov VV, Chalisova NI, Kvetnoĭ IM, Konovalov SS. Sochetannoe vliianie vilona i tsiklofosfana na transplanty opukholeĭ i éksplantaty limfoidnoĭ tkani mysheĭ i krys raznogo vozrasta [Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age]. Adv Gerontol. 2003;12:128-131.
  3. Khavinson VK, Anisimov VN, Zavarzina NY, et al. Effect of vilon on biological age and lifespan in mice. Bull Exp Biol Med. 2000;130(7):687-690. doi:10.1007/BF02682106.
  4. Anisimov VN, Loktionov AS, Khavinson VK, Morozov VG. Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mech Ageing Dev. 1989;49(3):245-257. doi:10.1016/0047-6374(89)90075-4.
  5. Khavinson VKh, Egorova VV, Timofeeva NM, Malinin VV, Gordova LA, Gromova LV. Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats. Bull Exp Biol Med. 2002;133(5):494-496. doi:10.1023/a:1019878224754.
  6. Lezhava T, Khavison V, Monaselidze J, et al. Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people. Biogerontology. 2004;5(2):73-79. doi:10.1023/B:BGEN.0000025070.90330.7f.
  7. Lezhava T, Monaselidze J, Kadotani T, Dvalishvili N, Buadze T. Anti-aging peptide bioregulators induce reactivation of chromatin. Georgian Med News. 2006;(133):111-115.
  8. Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med. 2002;133(3):293-299. doi:10.1023/a:1015859322630.