Syn-Coll and it’s Potential to Increase Skin Firmness

by | Sep 21, 2022 | Research


Syn-coll peptide or Palmitoyl Tripeptide-5 is a peptide that can promote the production of Type I and Type III collagen while inhibiting its degradation (1). It is also known as Palmitoyl Tripeptide-5 or Tripeptide-5. Syn-coll peptide performs all these functions by activating the transforming growth factor.

Research has shown potential in improving wound healing, skin strength, the vascular supply to the skin, and skin hydration by increasing Type I and Type III collagen.

Syn-coll peptide functions similarly to Thrombospondin-1 by stimulating the breakdown of collagen caused by transforming growth factors.

A naturally occurring peptide called TSP-1 promotes TGF- activity. Syn-coll peptide has the same properties as TSP-1 in increasing Type I and III collagen levels in dermal (skin) fibroblasts. According to experimental results, Syn-coll raises type I and III collagen levels by 2-3 folds above normal levels. This effect lasts for about 72 hours before it fades (2). Varga et al. further suggest, ‘Our results indicate that TGF beta causes a marked enhancement of the production of types I and III collagens and fibronectin by cultured normal human dermal fibroblasts. The rate of collagen production by fibroblasts exposed to TGF beta was 2-3-fold greater than that of control cells. These effects were associated with a 2-3-fold increase in the steady-state amounts of types I and III collagen mRNAs and a 5-8-fold increase in the amounts of fibronectin mRNAs as determined by dot-blot hybridization with specific cloned cDNA probes. In addition, the increased production of collagen and fibronectin and the increased amounts of their corresponding mRNAs remained elevated for at least 72 h after the removal of TGF beta. These findings suggest that TGF beta may play a major role in the normal regulation of extracellular matrix production in vivo and may contribute to the development of pathological states of fibrosis’ (2)

TSP-1 is a protein found in the extracellular matrix (ECM), and it lives in the skin alongside collagen and elastin. TSP-1 is harvested in part for use in Syn-coll peptide production. This section activates latent TGF-.


Potential Benefits

Research regarding Palmitoyl Tripeptide-5, like TSP-1, shows that this peptide can improve wound healing (3). It participates in the development of skin structures after birth.

  • The Syn-coll peptide also inhibits matrix metalloproteinase I and III activity (MMP1 and MMP3). Enzymes that degrade collagen are known as matrix metalloproteinases. These enzymes are beneficial because they recycle collagen after aging but are uncontrollably increased to abnormal levels in conditions such as inflammation. As a result, premature skin damage, lines, wrinkles, and other signs of aging may appear (3).
  • Cosmeceutical science seeks to improve skin health by using Syn-coll peptides. Therefore, increased collagen synthesis or decreased collagen degradation enhances skin health. Palmitoyl Tripeptide-5 boosts collagen synthesis by about 119% (4). As a result, wrinkle appearance improves, skin firmness improves, and fine lines fade, making the skin appear younger and healthier.
  • Syn-coll may help the body eliminate toxins and reduce the appearance of wrinkles and fine lines. Syn-coll interacts with the skin, keeping toxins at bay. This procedure shields the body from the harmful effects of free radicals.
  • By inhibiting MMP1 and MMP3 activity, Syn-coll peptide can help to prevent collagen breakdown. These findings suggest that Syn-coll peptide can promote the formation of Type I and Type III collagen while inhibiting collagen breakdown by the enzymes, as mentioned earlier.
  • Syn-coll, a synthetic peptide component, has two effects. It increases collagen production by replicating the human body’s technique for activating latent transforming growth factor beta, TGF (Tissue Growth Factor), a critical component in collagen synthesis. It also protects collagen from breakdown by inhibiting matrix metalloproteinases (MMP). Both activities work together to keep the skin’s structural integrity intact.
  • Compared to a placebo, Syn-coll peptide is about 3.5 times more effective at reducing wrinkles. According to the researchers, Palmitoyl Tripeptide-5 is 60% more effective than Palmitoyl Pentapeptide (5).



Syn-coll can also improve skin firmness and moisture while reducing the appearance of wrinkles. Syn-coll seems to accomplish this by activating the transforming growth factor. The Syn-coll peptide may also inhibit collagen degradation by stimulating the TSP-1-induced transforming growth factor.

Syn-coll (Palmitoyl Tripeptide-5) is a wrinkle-reducing and anti-aging peptide. However, this peptide/chemical is only for educational and scientific purposes and should not be consumed or used by humans.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020 Oct 30;8:572923. doi: 10.3389/fchem.2020.572923.
  2. Varga J, Rosenbloom J, Jimenez SA. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J. 1987 Nov 1;247(3):597-604
  3. Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021 Jul 21;14(8):702. doi: 10.3390/ph14080702.
  4. Fadilah NIM, Rahman MBA, Yusof LM, Mustapha NM, Ahmad H. The Therapeutic Effect and In Vivo Assessment of Palmitoyl-GDPH on the Wound Healing Process. Pharmaceutics. 2021 Feb 1;13(2):193. doi: 10.3390/pharmaceutics13020193.
  5. Bucay VW, Day D. Adjunctive skin care of the brow and periorbital region. Clin Plast Surg. 2013 Jan;40(1):225-36. doi: 10.1016/j.cps.2012.09.003
  6. Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021 Jul 21;14(8):702. doi: 10.3390/ph14080702