Syn-Coll (Palmitoyl Tripeptide-5) (200mg)


Syn-Coll (Palmitoyl Tripeptide-5) peptides are Synthesized and Lyophilized in the USA.

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Syn-Coll (Palmitoyl Tripeptide-5) Peptide

Syn-Coll, otherwise known as Palmitoyl Tripeptide-5 or Tripeptide-5, is a synthetic peptide that was developed to enhance the production of type I collagen. Scientific research in animal models suggest that it may be effective in this intention, reducing the prevalence of wrinkles in areas prone to increased muscle contraction. It appears to repair damages caused by photo-aging, and Syn-Coll has also been suggested to support the regeneration of skin protein production, such as elastin or collagen. Syn-Coll (Palmitoyl Tripeptide-5) is the synthetic equivalent of Thrombospondin 1 (TSP-1). It appears to mimic the functions of TSP-1, possibly aiding in the prevention of collagen degeneration via stimulating the release of TGF-𝛃 induced by TSP-1.[1]


Sequence: Palmitoyl-Lys-Val-Lys

Molecular Formula: C33H65N5O5

Molecular Weight: 611.9 g/mol

PubChem: CID 11950477

Synonyms: Palmitoyl Tripeptide-5 or Tripeptide-5

Syn-Coll Research

Syn-Coll (Palmitoyl Tripeptide-5) General Research
The potential of Syn-Coll (Palmitoyl Tripeptide-5) to promote Type I and Type III collagen formation is still under review. Type I collagen is found in bones, skin, and muscle, and Type II collagen is found in the lungs, skin, and vascular system. Palmitoyl Tripeptide-3 has been suggest via animal studies to increase skin strength, promote wound healing, increase vascular supply to the skin, and improve skin moisture by stimulating collagen formation. Syn-Coll (Palmitoyl Tripeptide-5) is the synthetic counterpart of TSP-1, developed to increase TGF- activity.[2] TGF- induces an increase in the amount of type I and type III collagen generated by dermal fibroblasts. Animal studies suggest that Syn-Coll may have the ability to boost collagen formation by 2-3 times over baseline levels. This impact appears to last at least 72 hours before it starts to fade.[3] The researchers note that β€œThese effects were associated with a 2-3-fold increase in the steady-state amounts of types I and III collagen mRNAs and a 5-8-fold increase in the amounts of fibronectin mRNAs as determined by dot-blot hybridization with specific cloned cDNA probes.” TSP-1 is an extracellular matrix protein and is found in the skin near collagen and elastin. A specific component of TSP-1, acquired for use in Syn-Coll, appears to activate latent TGF-. TSP-1 is considered to promote wound healing and trigger the postnatal growth of skin structures, according to laboratory research employing dermal fibroblasts generated in tissue culture and scientific investigations in animal models.[4] The researchers also note that β€œA TSP-dependent mechanism of activation may be locally important during wound healing and in post-natal development of epithelial structures.” In one study, Syn-Coll was reported to deactivate matrix metalloproteinase-1 and 3 (MMP1 and MMP3) β€” enzymes that actively limit the formation of type I and type III collagen. These enzymes may recycle collagen as it ages, but in inflammatory situations, it can be drastically enhanced.

Syn-Coll (Palmitoyl Tripeptide-5) and Wrinkle Reduction
Syn-Coll (Palmitoyl Tripeptide-5) has been suggested by researchers to contribute to a reduction in wrinkle depth and may aid preventing toxins from entering the skin barrier. This process may add an additional safeguard from the harmful impacts of free radicals buildup. Studies suggest that Syn-Coll may prevent collagen breakdown by suppressing MMP1 and MMP3 activity. These findings imply that Syn-Coll may promote type I and type III collagen formation and inhibit collagen breakdown, by up to 119%. Syn-Coll is reported by researchers to be approximately 3.5 times more impactful than a placebo in wrinkle depth reduction. Syn-Coll (Palmitoyl Tripeptide-5), according to scientists, may be up to 60% more powerful than Palmitoyl Pentapeptide.[5]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Thorsen, M., Yde, B., Pedersen, U., Clauden, K., & Lawesson, S. O. (1983). Studies on amino acids and peptides-V: Syntheses of endothionated melanostatin analogs. Tetrahedron, 39(20), 3429-3435.
  2. Trookman, N. S., Rizer, R. L., Ford, R., Ho, E., & Gotz, V. (2009). Immediate and Long-term Clinical Benefits of a Treatment for Facial Lines and Wrinkles. The Journal of clinical and aesthetic dermatology, 2(3), 38–43.
  3. Varga, J., Rosenbloom, J., & Jimenez, S. A. (1987). Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. The Biochemical journal, 247(3), 597–604. doi:10.1042/bj2470597.
  4. Murphy-Ullrich, J. E., & Poczatek, M. (2000). Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine & growth factor reviews, 11(1-2), 59–69.
  5. Bucay, V. W., & Day, D. (2013). Adjunctive skin care of the brow and periorbital region. Clinics in plastic surgery, 40(1), 225–236. doi:10.1016/j.cps.2012.09.003.
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This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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