Syn-Coll (Palmitoyl Tripeptide-5) (Topical) (200mg)


Palmitoyl Tripeptide-5 or Tripeptide-5

Discount per Quantity

5 - 95%$206.15
10 +10%$195.30
SKU: Syn-Coll-Palmitoyl-Tripeptide-5-Topical-200mg Category:


What Is Syn-Coll (Palmitoyl Tripeptide-5) (Topical)?

Syn-Coll or Palmitoyl Tripeptide-5 or Tripeptide-5 is a synthetic peptide that enhances the production of type I collagen. Scientific research in animal models shows that it can reduce the prevalence of wrinkles in skin areas prone to aging. It repairs damages caused by photo-aging. Syn-Coll can also regenerate and smoothen skin, refine pore appearance, improve skin elasticity and firmness, and better the texture of the skin.
Palmitoyl Tripeptide-5 is the synthetic equivalent of Thrombospondin 1 (TSP-1). It also mimics the functions of TSP-1, aiding in the prevention of collagen degeneration via stimulating the release of TGF-𝛃 induced by TSP-1.


Sequence: Palmitoyl-Lys-Val-Lys

Molecular Formula: C33H65N5O5

Molecular Weight: 611.9 g/mol

PubChem: CID 11950477

Synonyms: Palmitoyl Tripeptide-5 or Tripeptide-5

Reconstitution: Required

Syn-Coll (Palmitoyl Tripeptide-5) Research

The Benefits of Palmitoyl Tripeptide-5
The potential of Palmitoyl Tripeptide-5 to promote Type I and Type III collagen formation is still under review. Type I collagen, on the other hand, is found in bones, skin, and muscle, and Type II collagen is found in the lungs, skin, and vascular system. Palmitoyl Tripeptide-3 has been shown through animal studies to increase skin strength, promote wound healing, increase vascular supply to the skin, and improve skin moisture by stimulating collagen formation.
Syn-Coll (Palmitoyl Tripeptide-5)is the synthetic counterpart of TSP-1, increasing TGF- activity. TGF- induces an increase in the amount of type I and type III collagen generated by dermal fibroblasts. Animal studies demonstrate that Syn-Coll can boost collagen formation by 2-3 times over baseline levels. This impact lasts at least 72 hours before it starts to fade.
TSP-1 is an extracellular matrix protein; hence it is found in the skin near collagen and elastin. A specific component of TSP-1, acquired for use in Syn-Coll, activates latent TGF-. TSP-1 can promote wound healing and trigger the postnatal growth of skin structures, according to laboratory research employing human dermal fibroblasts generated in tissue culture and scientific investigations in animal models.
According to the study, Syn-Coll can deactivate matrix metalloproteinase-1 and 3 (MMP1 and MMP3)—enzymes that actively limit the formation of type I and type III collagen. These enzymes may recycle collagen as it ages, but in inflammatory situations, it can be drastically enhanced—resulting in the predominance of fine lines, wrinkles, and premature skin damage.

The Role of Syn-Coll in the Reduction of Wrinkles
Collagen is one of the most abundant proteins in the skin. It is responsible for giving the skin a firm appearance. The levels of collagen decline with increasing age and can result in the appearance of signs of aging.
The goal of cosmeceutical science focusing on the skin is to promote collagen health. Collagen health can be enhanced by increasing collagen synthesis or decreasing collagen disintegration. Few compounds and peptides have been discovered by scientific studies to boost collagen formation. Among the few, experts believe that Syn-Coll may stimulate collagen synthesis and production by around 119%, resulting in wrinkle reduction, increased skin firmness, and decreased fine lines. As a result, the skin seems healthier and younger.
It is worth noting that Palmitoyl Tripeptide-5 not only decreases the appearance of wrinkles and fine lines but can also help reduce the number of toxins in the body. Syn-Coll interacts with the skin and prevents toxins from entering the skin. This process safeguards the organism from the harmful effects of free radicals.
In vivo investigations suggest that Syn-Coll can prevent collagen breakdown by suppressing MMP1 and MMP3 activity. These findings imply that Syn-coll can promote type I and type III collagen formation and inhibit collagen breakdown by the abovementioned enzymes. Syn-Coll is approximately 3.5 times more effective than a placebo at reducing the prevalence of wrinkles. Palmitoyl Tripeptide-5, according to scientists, is 60% more powerful than Palmitoyl Pentapeptide.

The Side Effects of Palmitoyl Tripeptide-5 (Syn-Coll)
Although experts are still reviewing Syn-Coll, no visible negative effects have been documented. There have been no reports of allergic reactions, toxicity, sensitivity, or hormone disruption.
Anti-aging products irritate those with delicate skin. Itching, redness, and stinging at the place of application are all frequent skin responses. However, suppose any of these adverse effects occur; In that case, the patient should be sent to a dermatologist to evaluate if Syn-Coll causes them and if alternative treatment options are available.


Syn-Coll is a potent anti-aging and anti-wrinkle peptide. The results of preliminary evidence suggest this peptide has potent anti-aging benefits. This peptide/chemical, however, is just for educational and scientific reasons and is not intended for human intake or usage.

All orders ship same day if placed by 2pm PST. Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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