Syn-Coll (Palmitoyl Tripeptide-5) (Topical) (200mg)


Syn-Coll (Palmitoyl Tripeptide-5) peptides are Synthesized and Lyophilized in the USA.

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Quantity5 - 910 +
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SKU: Syn-Coll-Palmitoyl-Tripeptide-5-Topical-200mg Category:


What is the Syn-Coll (Palmitoyl Tripeptide-5) peptide?

Syn-Coll, otherwise known as Palmitoyl Tripeptide-5 or Tripeptide-5, is a synthetic peptide that was developed to enhance the production of type I collagen. Scientific research in animal models suggest that it may be effective in this intention, reducing the prevalence of wrinkles in skin areas prone to aging. It appears to repair damages caused by photo-aging, and Syn-Coll may also regenerate and smoothen skin, refine pore appearance, improve skin elasticity and firmness, bettering the texture of the skin. Syn-Coll (Palmitoyl Tripeptide-5) is the synthetic equivalent of Thrombospondin 1 (TSP-1). It appears to mimic the functions of TSP-1, possibly aiding in the prevention of collagen degeneration via stimulating the release of TGF-𝛃 induced by TSP-1.[1]


Sequence: Palmitoyl-Lys-Val-Lys

Molecular Formula: C33H65N5O5

Molecular Weight: 611.9 g/mol

PubChem: CID 11950477

Synonyms: Palmitoyl Tripeptide-5 or Tripeptide-5

Reconstitution: Required

Syn-Coll Research

Syn-Coll (Palmitoyl Tripeptide-5) General Research
The potential of Syn-Coll (Palmitoyl Tripeptide-5) to promote Type I and Type III collagen formation is still under review. Type I collagen is found in bones, skin, and muscle, and Type II collagen is found in the lungs, skin, and vascular system. Palmitoyl Tripeptide-3 has been suggest via animal studies to increase skin strength, promote wound healing, increase vascular supply to the skin, and improve skin moisture by stimulating collagen formation. Syn-Coll (Palmitoyl Tripeptide-5) is the synthetic counterpart of TSP-1, developed to increase TGF- activity.[2] TGF- induces an increase in the amount of type I and type III collagen generated by dermal fibroblasts. Animal studies suggest that Syn-Coll may have the ability to boost collagen formation by 2-3 times over baseline levels. This impact appears to last at least 72 hours before it starts to fade.[3] The researchers note that “These effects were associated with a 2-3-fold increase in the steady-state amounts of types I and III collagen mRNAs and a 5-8-fold increase in the amounts of fibronectin mRNAs as determined by dot-blot hybridization with specific cloned cDNA probes.” TSP-1 is an extracellular matrix protein and is found in the skin near collagen and elastin. A specific component of TSP-1, acquired for use in Syn-Coll, appears to activate latent TGF-. TSP-1 can promote wound healing and trigger the postnatal growth of skin structures, according to laboratory research employing human dermal fibroblasts generated in tissue culture and scientific investigations in animal models.[4] The researchers also note that “A TSP-dependent mechanism of activation may be locally important during wound healing and in post-natal development of epithelial structures.” In one study, Syn-Coll was reported to deactivate matrix metalloproteinase-1 and 3 (MMP1 and MMP3) — enzymes that actively limit the formation of type I and type III collagen. These enzymes may recycle collagen as it ages, but in inflammatory situations, it can be drastically enhanced—resulting in the predominance of fine lines, wrinkles, and premature skin damage.

Syn-Coll (Palmitoyl Tripeptide-5) and Wrinkle Reduction
Collagen is one of the most abundant proteins in the skin. It is responsible for giving the skin a firm appearance. The levels of collagen decline with increasing age and can result in the appearance of signs of aging. The goal of cosmeceutical science focusing on the skin is to promote collagen health. Collagen health can be enhanced by increasing collagen synthesis or decreasing collagen disintegration. Few compounds and peptides have been discovered by scientific studies to boost collagen formation. Among the few, experts believe that Syn-Coll may stimulate collagen synthesis and production by up to 119%, resulting in possible wrinkle reduction, increased skin firmness, and decreased fine lines.  It is worth noting that Syn-Coll (Palmitoyl Tripeptide-5) appears to not only decrease the appearance of wrinkles and fine lines but it may also help reduce the number of toxins in the body. Syn-Coll appears to interact directly with the skin and prevents toxins from entering the dermis. This process may add an additional safeguard for the organism from the harmful effects of free radicals. In vivo investigations suggest that Syn-Coll may prevent collagen breakdown by suppressing MMP1 and MMP3 activity. These findings imply that Syn-Coll may promote type I and type III collagen formation and inhibit collagen breakdown by the above-mentioned enzymes. Syn-Coll is reported by researchers to be approximately 3.5 times more effective than a placebo at reducing the prevalence of wrinkles. Syn-Coll (Palmitoyl Tripeptide-5), according to scientists, is 60% more powerful than Palmitoyl Pentapeptide.[5]

Syn-Coll (Palmitoyl Tripeptide-5) Safety Profile
Although experts are still reviewing Syn-Coll, no visible negative effects have been documented. There have been no reports of allergic reactions, toxicity, sensitivity, or hormone disruption. In general, anti-aging products can irritate those with delicate skin. Itching, redness, and stinging at the place of application are all frequent skin responses.


Syn-Coll has been extensively researched for its potential as an effective anti-aging and anti-wrinkle peptide. Preliminary research studies suggest this peptide has potent anti-aging benefits. This peptide/chemical, however, is just for educational and scientific reasons and is not intended for human intake or usage.


  1. Thorsen, M., Yde, B., Pedersen, U., Clauden, K., & Lawesson, S. O. (1983). Studies on amino acids and peptides-V: Syntheses of endothionated melanostatin analogs. Tetrahedron, 39(20), 3429-3435.
  2. Trookman, N. S., Rizer, R. L., Ford, R., Ho, E., & Gotz, V. (2009). Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. The Journal of clinical and aesthetic dermatology, 2(3), 38–43.
  3. Varga, J., Rosenbloom, J., & Jimenez, S. A. (1987). Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. The Biochemical journal, 247(3), 597–604. doi:10.1042/bj2470597.
  4. Murphy-Ullrich, J. E., & Poczatek, M. (2000). Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine & growth factor reviews, 11(1-2), 59–69.
  5. Bucay, V. W., & Day, D. (2013). Adjunctive skin care of the brow and periorbital region. Clinics in plastic surgery, 40(1), 225–236. doi:10.1016/j.cps.2012.09.003.
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