Syn-coll peptide improves skin firmness and moisture while reducing the appearance of wrinkles.

Syn-coll or Palmitoyl Tripeptide-5 is a peptide that promotes the production of Type I and Type III collagen while inhibiting its degradation. It is also known as Palmitoyl Tripeptide-5 or Tripeptide-5. Syn-coll peptide performs all these functions by activating the transforming growth factor.

Humans can find Collagen type I in bones, muscles, and skin. Type III collagen can be found in the skin, the vascular system, and the lungs. Syn-coll improves wound healing, skin strength, the vascular supply to the skin, and skin hydration by increasing Type I and Type III collagen.

Syn-coll peptide functions similarly to Thrombospondin-1. It stimulates the breakdown of collagen caused by transforming growth factors.

The Benefits of Syn-coll Peptide

A naturally occurring peptide called TSP-1 promotes TGF- activity. Syn-coll peptide has the same properties as TSP-1 in increasing Type I and III collagen levels in dermal (skin) fibroblasts. According to experimental results, Syn-coll raises type I and III collagen levels by 2-3 folds above normal levels. This effect lasts for about 72 hours before it fades.

TSP-1 is a protein found in the extracellular matrix (ECM), and it lives in the skin alongside collagen and elastin. TSP-1 is harvested in part for use in Syn-coll peptide production. This section activates latent TGF-.

  • Palmitoyl Tripeptide-5, like TSP-1, works to improve wound healing. It participates in the development of skin structures after birth.
  • Syn-coll peptide also inhibits matrix metalloproteinase I and III activity (MMP1 and MMP3). Enzymes that degrade collagen are known as matrix metalloproteinases. These enzymes are beneficial because they recycle collagen after aging but are uncontrollably increased to abnormal levels in conditions such as inflammation. As a result, premature skin damage, lines, wrinkles, and other signs of aging may appear.
  • Cosmeceutical science seeks to improve skin health by using Syn-coll peptide. Therefore, increased collagen synthesis or decreased collagen degradation enhances skin health. Palmitoyl Tripeptide-5 boosts collagen synthesis by about 119%. As a result, wrinkle appearance improves, skin firmness improves, and fine lines fade, making the skin appear younger and healthier.
  • Syn-coll peptide may help the body eliminate toxins and reduce the appearance of wrinkles and fine lines. Syn-Coll interacts with the skin, keeping toxins at bay. This procedure shields the body from the harmful effects of free radicals.
  • By inhibiting MMP1 and MMP3 activity, Syn-coll peptide can help to prevent collagen breakdown. These findings suggest that Syn-coll peptide can promote the formation of Type I and Type III collagen while inhibiting collagen breakdown by the enzymes, as mentioned earlier.
  • Syn-coll, a synthetic peptide component, has two effects. It increases collagen production by replicating the human body’s technique for activating latent transforming growth factor beta, TGF (Tissue Growth Factor), a critical component in collagen synthesis. It also protects collagen from breakdown by inhibiting matrix metalloproteinases (MMP). Both activities work together to keep the skin’s structural integrity intact.
  • Compared to a placebo, Syn-coll peptide is about 3.5 times more effective at reducing wrinkles. According to the researchers, Palmitoyl Tripeptide-5 is 60% more effective than Palmitoyl Pentapeptide.

Syn-coll peptide is in different forms such as creams, lotions, powders, serums, sprays, and sticks. And can be applied as anti-aging products, body balms, creams & lotions, face cream & lotions, and hand cream.

  • Syn-coll peptide alters the effects of photo-aging damage.
  • The peptide improves skin texture, elasticity, and firmness.
  • Syn-coll is a peptide that prevents stretching. It can also be cold processed.
  • Palmitoyl Tripeptide-5 moisturizes, protects, and restores the skin’s natural color.

The Adverse Effects of Syn-coll Pepide

Even though experts are still reviewing Syn-coll peptide, no adverse effects have been documented. There haven’t been reports of allergic reactions, toxicity, sensitivity, or hormone disruption.

Those with sensitive skin are irritated by anti-aging products. Common skin reactions include itching, redness, and stinging at the application site. But suppose one of these side effects occurs. In that case, the patient should see a dermatologist to see if Syn-coll peptide is the cause.


Syn-coll peptide also improves skin firmness and moisture while reducing the appearance of wrinkles. Syn-coll accomplishes all these tasks by activating the transforming growth factor-. Syn-coll peptide also inhibits collagen degradation by stimulating the TSP-1-induced transforming growth factor.

Syn-Coll (Palmitoyl Tripeptide-5) is a wrinkle-reducing and anti-aging peptide. However, this peptide/chemical is only for educational and scientific purposes and should not be consumed or used by humans.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

Role of Copper Peptide in the Improvement of the Growth of Hair Follicle

Copper Peptide is formed as a result of the affinity of the human peptide, GHK (glycyl-L-histidyl-L-lysine), to the Cu(2+) (Copper 2+). In the human body, the Copper Peptide has varied roles like collagen stimulation, anti-inflammatory, anti-oxidant effects, enhancing...

How does Epitalon reverse aging?

Epitalon is a peptide that has been majorly studied for its anti-aging influence. The findings have been restricted to animal studies. Hence the efficacy of the molecule in humans is subject to conjecture. The molecule has been shown to reverse the aging process...

Unique Effect of Sermorelin on Sleep

What is Sermorelin peptide? Sermorelin peptide is a synthetic analog of the naturally occurring growth hormone-releasing hormone (GHRH). GHRH is a 44 amino acid long peptide, and Sermorelin peptide comprises the first 29 amino acids. The shortened peptide is...

Ipamorelin and GHRP-2

Ipamorelin and GHRP-2 are synthetic peptides that enhance the secretion of growth hormones. Owing to the identical physiological role, they are often mistaken to be the same. On the contrary, both molecules are distinctly different and only share a common functional...

Peptides for BodyBuilding: Do They Work and Are They Safe?

Peptides are short amino acid sequences of constant interest in the bodybuilding community. They are considered an important tool in improving the performance of bodybuilders, especially those who pursue it as a profession. Hence, the growth hormone secretagogue (GHS)...