Fragment 176-191, is a synthetic peptide fragment of human growth hormone (HGH). It spans from the 176th to the 191st amino acid residues of the human growth hormone. The fragment comprises an additional tyrosine amino acid residue apart from amino acids 177-191. Research has shown that Frag 176-191, being a synthetic Growth Hormone Releasing Hormone (GHRH) agonist is a strong catalyst for catabolism of adipocytes. Interestingly, in 1959, human growth hormone was first associated with fat metabolism as well.

1. Fragment 176-191 and Fat Reduction

Fragment 176-191 exhibits a unique property to stimulate metabolism of adipose tissue. Research findings reveal that the molecule AOD9604 is more effective in triggering burning of fat than AOD9401 which preceded it. It follows the same mechanistic pathway for fat breakdown like HGH. It also inhibits conversion of food rich in fat into body fat. Clinical research and laboratory findings have led to the above observations with respect to the functional capabilities of the peptide fragment.
Long term administration of Frag 176-191 in mice has successfully reduced the fat burden in the treated animals through induction of weight loss. The precise reason for this effect is not yet completely understood. However, scientists opine that the binding of the peptide to beta(3)-adrenergic receptors present on the surface of white adipose tissues trigger the fat metabolism process. These receptors are well known to be associated with the metabolism of fat in the body. Binding of the peptide to the cognate receptors induces downstream signaling for mobilizing the stored fat cells to usable state by increasing the rate of metabolism. Interestingly, mice which genetically lack in β-3-adrenergic receptors also have undergone fat loss possibly through apoptosis of the white adipose tissues. Recent findings have shown that the peptide can also decrease body fat in the mid-abdomen of research subjects who have average build, are overweight or obese.

2. Frag 176-191 and Cardiac Disease

Frag 176-191 improves cardiac health in an indirect manner by mobilizing fat and reducing obesity. It thus reduces the chances of cardiac disease caused by obesity. The drug improves cardiac conditions by other mechanisms as well. These pathways are independent of β-3-adrenergic receptors and contribute towards the improvement of general metabolism, leading to improved cardiac health.

3. Joint Pain and Function

Studies involving Frag 176-191 have demonstrated that it helps to improve cartilage growth. Direct introduction of the peptide into arthritic joints in rats improves pain management, decreases movement disability and enhances general quality of life. The effect is enhanced in conjunction with other existing therapies. Both clinical examination and microscopic cartilage structure analysis in the affected joints have shown positive results upon Fragment 176-191 treatment of osteoarthritis. This highlights that application of this peptide can be beneficial in both prevention and treatment of osteoarthritis.

Other positive features of fragment 176-191

The peptide has shown other relevant physiological effects, apart from fat metabolism. As per studies, it improves bone mineral density and sleep patterns. Studies have also revealed that Fragment 176-191 enhances expression levels of IGF-1. IGF-1 mediates anti-aging effects like the human growth hormone.

Storage of peptides

It is recommended to use unopened vials of fragment 176-191 within 36 months. Once the peptide gets reconstituted, it has a shelf life of 14 days and should be used up within that span. The peptide requires a storage temperature between 2°C and 8°C.

Buy Fragment 176-191

The integrity of the research using the peptide can be ensured by purchasing products of USA origin. The quality of the product from BiotechPeptides is ensured through HPLC and Mass Spectromotery analysis. It is usually available in 5mg or 10mg vials. The peptide is packaged in lyophilized powder form.

In summary

Multiple researches have proven that fragment 176-191 of USA origin is beneficial in treatment of obesity and general reduction of body fat. The peptide also happens to overcome the adverse effects of Human Growth Hormone and hence is considered to be safer than HGH. As per the scientific studies conducted on animal models, use of the peptide over a span of 30 days in animal models has led to a significant decrease in body fat in the treated animals. The peptide has not demonstrated any serious adverse effect as long as it is administered within limits of permissible dosage. At present, Fragment 176-191 can be procured and used for academic research purpose only. It is yet to be approved for clinical administration.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

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