Fragment 176-191 (10mg)

(71 customer reviews)

$67.00

Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $63.65$60.30
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Fragment-176-191-10mg Category:

Description

What is the Fragment 176-191 peptide?

Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic effects of hGH without inducing the same side effects. Therefore, the peptide may potentially be used for anti-obesity treatments.

Specifications

AKA: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

CAS Number: 66004-57-7

Reconstitution: Required

Research

Frag 176-191, Fat Burning and Weight Loss
The fat-burning potential of Frag 176-191 stems from the peptide’s hypothetical ability to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesisscle. Research indicates that genetically modified mice that lack ADRB3 are resistant to the effect of hGH / Fragment 176-191. One experimental study observed that treatment of Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there may be secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.

Frag 176-191 and blood sugar levels
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions suggest that Frag 176-191 has the potential to treat prediabetes and type-2 diabetes.

Frag 176-191 and cartilage regeneration
Experimental research in Frag 176-191 suggests its ability to promote cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has observed that weekly administration of Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) appeared to be even more effective. Fragment 176-191 both independently and in combination with HA may help to improve the conditions of osteoarthritis. Thus there is the reason to include Frag 176-191 in the scope of beneficial treatments which may overcome the requirement of surgery.

Safety Studies in Fragment 176-191

Researchers have attempted to address the concern regarding the administration of hGH or its derivatives for weight loss. This concern arises from the fact that hGH has shown that exogenous use over extended periods can have significant physiological side effects such as:
– Diabetes
– Edema (swelling)
– Cancer
– Increased resistance to insulin
– Hypertension (high blood pressure)
– Acromegaly.
The Journal of Endocrinology and Metabolism published a study in 2013 which evaluated six research works conducted on the rate and relevance of detrimental effects of Fragment 176-191 peptide. The study is based strictly on the work that has abided by the placebo-controlled, randomized, and double-blinded model of a phase IIb clinical trial with the aim to achieve the highest possible standards of evidence. The study observed that administration of Fragment 176-191 appeared to exhibit no significant alterations compared to placebo control in:
– Physical findings
– Glucose levels
– Laboratory parameters
– Glucose tolerance
– IGF-1 levels
– Insulin sensitivity or,
– Rates of adverse events (such as headaches)
The meta-analysis has highlighted that the peptide may have the potential to deliver the same beneficial effects of hGH treatment without triggering the harmful effects of hGH. The studies speak in favor of regulated use of the synthetic peptide in clinical settings apart from providing insight into the moderation of human growth and development, fat metabolism, and energy homeostasis by the peptide. The studies thus open doors for more comprehensive understanding of energy homeostasis and targeted fat metabolism and ways of manipulating it.
It is important to note that hGH influences muscle growth and development while Fragment 176-191 peptide is strictly catabolic in nature. Studies indicate the peptide appears to trigger lipolysis in adipocytes without bringing about acromegaly or other adverse situations associated with hGH use. Mice models have also observed that the peptide does not appear to promote cellular proliferation.

Summarization of Research Areas of Frag 176-191

The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research in the domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.

References

  1. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
  2. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7. doi: 10.1152/ajpendo.2000.279.3.E501. PMID: 10950816.
  4. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  5. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

71 reviews for Fragment 176-191 (10mg)

  1. Ava Lee

    High-quality products & fast shipping!

  2. Aspen Sanders

    I love this company

  3. Charlie Green

    Legit products and quality company. I am very pleased with my experience so far

  4. Ava Lee

    Keep up the good work

  5. Ana White

    This same product goes for about 5 times as much at a compounding pharmacy. 5/5!

  6. Mildred Adamson

    Great products.
    Fast shipping.
    5 stars for everything.

  7. Corbyn Ezra

    Overall great experience with Biotech Peptides. Despite confusion at the start and a little struggle getting one of my prodcuts, they were kind enough to send 2 free-of-charge products along with my missing one!

  8. Odessa Burton

    I have ordered from Biotech Peptides a few times over the last year and they are always super quick delivering! You get text message updates about your order too. If you sign up for the newsletter you get discount codes regularly – Great job guys! Keep it up

  9. Archie Holmes

    Great service and quality stuff what more could you want!!!

  10. Dexter Webb

    USPS lost my package but I was sent a replacement. Free of charge! 4 stars for the delay even though I realize its not your fault/

  11. Tyra Campbell

    Amazing!

  12. Carlo Melwani

    Shipping is fast and reasonably priced.

  13. Deven Krantz

    Lots of information on their website to help find what you need. I have even bought or looked into peptides I was never interested in as well interested of it. It’s opened my curiosity to a new realm of research as well. Looking forward to working with topical options too!

  14. Kalyn Nicholson

    Everything I’ve ordered has been good quality so far.

  15. Russel Banks

    Prompt service

  16. Stephen Webb

    I’ve placed a bunch of orders with Biotech so far and have never had any issues. A quick turnaround and a good product. I guess I have been fortunate and have not run into issues with peptides being out of stock, they usually have everything I need when it is time for repurchase.

  17. Elizabeth Greg

    One of the most affordable places to get peptides! They also have some items on sale here and there. Even better is they offer deals when buying in bulk.

  18. Travis Edrington

    Best customer service and products I have ever had. And I have been a customer with other peptide sites before.

  19. Craig Osborne

    the promotions they send from time to time are great

  20. Halie Martin

    Just made my third order in 2 months! wish the sizes were a bit bigger! But they have good quality peptides.

  21. Richard Wilson

    Been with them for a while. Had got a promtoional email from them so decided to try them out. Their stuff checks out and They’re good at sending our promotions and have frquent sales.

  22. jacob harvey

    Give them two thumbs up

  23. Ben Kennedy

    I have been a loyal cutsomer since July and I can say this is the first time I was sent a broken vial. After inspecting it I’m not sure if it happened when packaging or during transit. I called them and spoke to Danny who was extremly helpful. They did not even ask me for any kid of proof and they just explained to me that I should be getting a new confirmation email with a new order shortly. And due to the headache they even threw in a disocunt code for the next few orders. Such a great company in every way.

  24. PK Lewis

    Like the disocunts they send out periodically!

  25. james messar

    The customer service provided is unmatched. My order came in this morning and even though the box clearly says “FRAGILE” the carrier mishandelded it. All my peptides were broken except a few here and there. I took a picture and emailed it to biotech and immediatly got a responce from Danny. They apologised even though it was not their fault and put in a rush order for me. The tracking number says I should be recieving it by tomorrow morning so fingers crossed.

  26. pete newman

    My peptides showed up in perfect condition. Vials were all in their box and were packaged safley.

  27. Kyle Edwards

    Got a disocunt code for my one year of buying with them!

  28. Alex Avila

    Searched for this product for a while and this is the only company that sells a qualitative and unaltered one.

  29. Taylor Taylor

    This is the best place to buy peptides, especially in bulk as they’re in stock with everything most of the time.

  30. Nick Perez

    La mejor compañía de péptidos. lo recomiendo con confianza

  31. Shawn Lachman

    Never had a better shopping experience than with Biotech

  32. Lupe Ortiz

    Customer service lived up to my expectation. It seems their was an issue with their site and they had a product on sale that was not supposed to be on sale. Customer service contacted me to let me know the mix up but that they would honor the sale prices listed this one time.

  33. Ruich Gillet

    The customer service of this company is second to none.

  34. Steven Welsh

    I like that when you can you get a person talking to you and not a machine/robot. Call times are also fast, typically if I need to call in my issue is fixed within 20 minutes.

  35. micheal golovanevsky

    Company is great. Straight forward and to the point with the entire process.

  36. Bobby kohan

    The quality of their products is unmatched

  37. Justin Gellman

    Found you guys from a google search. Peptides are fairly priced and I like that theres discount codes sent out periodically as well.

  38. Eli Reinach

    Peptides are great quality and highest purity I have found.

  39. Cameron Sheron

    My company has been working with Biotech since the start and we never had any issues with them whatsoever. We highly recommend them. Don’t be scared to contact them to work put potential deals or see if they’d have a discount. Like I previously said, i work for a lab company and we like to place big orders. If you need to request anyone Taylor or Danny would be your best bet!

  40. Nick Jaffe

    They never fail to amaze me with the quality of their products

  41. James Adam

    I have bought this product from other suppliers before, but this exceeded all my expectations.

  42. Edwin Marque

    This product works just as described. Follow the storage directions to a T and they’ll last you a while. Just a suggestion I’d make an extra page explaining how it all works as well. I know when I first started out working with peptides I felt a little lost and had to do a lot of research about it. I saw their blog page and it doesn’t seem to have any directions on that (or I did not find it).

  43. Chris Lopez

    Nunca volveré a comprar a otros proveedores. Esta es la compañia perfecta

  44. Chase Nelson

    I never needed a peptide Biotech did not have. They have such a huge range of peptides, it’s crazy

  45. Ciley Kappetta

    This product improved my research considerably.

  46. Rehan Choudhury

    I would recommend this to those working with peptides or to anyone interested in conducting high quality research. They are effective and high quality. I also caution anyone storing them to not freeze and thaw them too much, Has happened to me a few times where even the highest and purest quality peptides just get ruined and then you’re left with a useless peptide.

  47. Ricardo Gonzalez

    Estoy muy satisfecho con mi pedido. Volvere a comprar seguro

  48. Yusuf Bey

    Five stars from me for sure!

  49. Chris O’Connor

    I recommended them to all my colleagues. Their peptides are remarkable and they have them in stock more frequently than other places.

  50. Annie Cheng

    New customer here! I have placed 3 orders so far and they were honoured amazingly, plus they gave me a discount after making my first purchase with them.

  51. Joe Amin

    I bought this in bulk and everything went smoothly. Products came in one big box rather than in separate boxes and deliveries. They seemed pretty well packages as well and I wasn’t worried about any damages.

  52. Eric Chavez

    I will be buying again for sure. Products are fantastic

  53. Noam Belkin

    Blogs are a nice way to understand some of the peptides and what works better with what type of research.

  54. Kevin Harvey

    Very good product

  55. Travis Crom

    Acts faster than any other compound of its kind.

  56. Wayne Robinson

    Unmatched quality, I do see a difference in my work. Also very content with working with them as they fix issues right away and handle it professionally as well.

  57. Chris Anderson

    Products are consistently great. Feel like they changed their shipping company because I used to get packages with a vial or two broken from transit but it’s been smooth sailing for a while.

  58. Nate Adams

    Coworkers rave about the peptides from here and after my research I can see why.

  59. Haiwei Luo

    I usually buy this in bulk and not once I had any problems storing it for a later use. If you do it right it will last a while just like any peptide. But if you store it incorrectly, you’ll be placing more orders than you’d like.

  60. AJ Cardenas

    The shelf life on this one is amazing if you follow the directions correctly

  61. Jose Costa

    Los mejores péptidos que he probado seguro

  62. Cal Goldsman

    Just got my order in!Got it a day before estimated so nice surprise. I was able to start working on my projects earlier as well. I have been shopping here for a few months now and they are one company that sticks to a tight schedule and gets products out as quickly as they come in.

  63. Tony Pipkin

    I will be buying this product again. It performed beautifully in my research

  64. Aria Hillas

    Fantastic product, works very well and the purity speaks for itself. Great find and can’t wait to utilize more of Biotech’s peptides.

  65. Peter Stewart

    A must-try, for sure

  66. Tim Wesler

    This is my all time favorite product. Versatile and when store correctly lasts a while. That’s how you know the quality is equally as great as well. I will say the prices are fair as well. Not the cheapest but better than some other places.

  67. Eddie Kean

    I will be buying again for sure

  68. Jon Bechtel

    Oustanding service and amazing products

  69. Hal Vapnik

    Everything from quality, purity, customer service and delivery is top notch

  70. Ron Anderson

    Quite effective. switched to this from AOD 9604 and I definitely made the right choice.

  71. Kris Ornelas

    My company has switched to BP as a supplier received a month ago and we have not had any issues. We ordered 50 vials of the Frag and received a free Bac water on the house.

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