Description
What Is Fragment 176-191 Peptide?
Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined due to research on animal systems which has proven that Fragment 176-191 enhances fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as the suppression of carbohydrate metabolism, altered sensitivity towards insulin, the promotion of long bone growth, and heightened insulin-like growth factor-1(GF-1) levels. Extensive animal studies have shown that the synthetic fragment enhances the lipolytic effects of hGH without inducing the same side effects. Hence the peptide can be used for anti-obesity treatments.
Fragment 176-191 SPECIFICATIONS
AKA: Frag 176-191
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
CAS Number: 66004-57-7
Reconstitution: Required
Physiological effects of Frag 176-191
1. Burning of fat and Weight Loss
The fat-burning action of Fragment 176-191 peptide is brought about by increasing the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the fragment upon interaction with ADRB3 directly enhances fat burning in adipose tissue and triggers thermogenesis in skeletal muscle. Genetically modified mice that lack ADRB3 are resistant to the effect of hGH / fragment 176-191.
Studies have shown treatment of fragment 176-191 causes up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide mediates weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there are secondary pathways involved in energy homeostasis that are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.
2. Decrease in Blood Sugar
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions prove that the fragment has the potential to treat prediabetes and type-2 diabetes.
3. Promotion of Cartilage Regeneration
Among other beneficial effects of Fragment 176-191 is the ability of cartilage regeneration. An article published by a Korean group in 2015 revealed that synthetic peptides could bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has highlighted that weekly injection of Fragment 176-191 improve cartilage growth (within laboratory measures) and its co-administration with hyaluronic acid (HA) is more effective. Fragment 176-191, both independently and in combination with HA helps to improve the conditions of osteoarthritis. Thus there is the scope of a better and more beneficial treatment involving this synthetic fragment which will overcome the requirement of surgery.
Safety Studies for frag 176-191
There is a concern regarding the administration of hGH or its derivatives for weight loss. This concern arises from the fact that hGH has shown that exogenous use over extended periods can have significant physiological side effects such as:
– Diabetes
– Edema (swelling)
– Cancer
– Increased resistance to insulin
– Hypertension (high blood pressure)
– Acromegaly.
The Journal of Endocrinology and Metabolism published a study in 2013 which evaluated six research works conducted on the rate and relevance of detrimental effects of Fragment 176-191 peptide. The study is based strictly on the work that has abided by the placebo-controlled, randomized, and double-blinded model of a phase IIb clinical trial with the aim to achieve the highest possible standards of evidence. The study has revealed that both intravenous and oral use of Fragment 176-191 shows no significant alterations compared to placebo control in:
– Physical findings
– Glucose levels
– Laboratory parameters
– Glucose tolerance
– IGF-1 levels
– Insulin sensitivity or
– Rates of adverse events (such as headaches).
The meta-analysis has highlighted that the peptide offers the beneficial effects of hGH treatment without triggering the harmful effects of hGH. The studies speak in favor of regulated use of the synthetic peptide in clinical settings apart from providing insight into the moderation of human growth and development, fat metabolism, and energy homeostasis by the peptide. The studies thus open doors for more comprehensive understanding of energy homeostasis and targeted fat metabolism and ways of manipulating it.
It is important to note that hGH influences muscle growth and development while Fragment 176-191 peptide is strictly catabolic in nature. It triggers lipolysis in adipocytes without bringing about acromegaly or other adverse situations associated with hGH use. Mice models have also shown that the peptide does not promote cellular proliferation.
Research on Fragment 176-191 peptide
The principal areas of research on Fragment 176-191 peptide explore its role in fat metabolism and weight loss. The findings have led to further research on the interesting domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.
Ava Lee –
High-quality products & fast shipping!
Aspen Sanders –
I love this company
Charlie Green –
Legit products and quality company. I am very pleased with my experience so far
Ava Lee –
Keep up the good work
Ana White –
This same product goes for about 5 times as much at a compounding pharmacy. 5/5!
Mildred Adamson –
Great products.
Fast shipping.
5 stars for everything.
Corbyn Ezra –
Overall great experience with Biotech Peptides. Despite confusion at the start and a little struggle getting one of my prodcuts, they were kind enough to send 2 free-of-charge products along with my missing one!
Odessa Burton –
I have ordered from Biotech Peptides a few times over the last year and they are always super quick delivering! You get text message updates about your order too. If you sign up for the newsletter you get discount codes regularly – Great job guys! Keep it up
Archie Holmes –
Great service and quality stuff what more could you want!!!
Dexter Webb –
USPS lost my package but I was sent a replacement. Free of charge! 4 stars for the delay even though I realize its not your fault/
Tyra Campbell –
Amazing!
Carlo Melwani –
Shipping is fast and reasonably priced.
Deven Krantz –
Lots of information on their website to help find what you need. I have even bought or looked into peptides I was never interested in as well interested of it. It’s opened my curiosity to a new realm of research as well. Looking forward to working with topical options too!
Kalyn Nicholson –
Everything I’ve ordered has been good quality so far.
Russel Banks –
Prompt service
Stephen Webb –
I’ve placed a bunch of orders with Biotech so far and have never had any issues. A quick turnaround and a good product. I guess I have been fortunate and have not run into issues with peptides being out of stock, they usually have everything I need when it is time for repurchase.
Elizabeth Greg –
One of the most affordable places to get peptides! They also have some items on sale here and there. Even better is they offer deals when buying in bulk.
Travis Edrington –
Best customer service and products I have ever had. And I have been a customer with other peptide sites before.
Craig Osborne –
the promotions they send from time to time are great
Halie Martin –
Just made my third order in 2 months! wish the sizes were a bit bigger! But they have good quality peptides.
Richard Wilson –
Been with them for a while. Had got a promtoional email from them so decided to try them out. Their stuff checks out and They’re good at sending our promotions and have frquent sales.
jacob harvey –
Give them two thumbs up
Ben Kennedy –
I have been a loyal cutsomer since July and I can say this is the first time I was sent a broken vial. After inspecting it I’m not sure if it happened when packaging or during transit. I called them and spoke to Danny who was extremly helpful. They did not even ask me for any kid of proof and they just explained to me that I should be getting a new confirmation email with a new order shortly. And due to the headache they even threw in a disocunt code for the next few orders. Such a great company in every way.
PK Lewis –
Like the disocunts they send out periodically!
james messar –
The customer service provided is unmatched. My order came in this morning and even though the box clearly says “FRAGILE” the carrier mishandelded it. All my peptides were broken except a few here and there. I took a picture and emailed it to biotech and immediatly got a responce from Danny. They apologised even though it was not their fault and put in a rush order for me. The tracking number says I should be recieving it by tomorrow morning so fingers crossed.
pete newman –
My peptides showed up in perfect condition. Vials were all in their box and were packaged safley.
Kyle Edwards –
Got a disocunt code for my one year of buying with them!
Alex Avila –
Searched for this product for a while and this is the only company that sells a qualitative and unaltered one.
Taylor Taylor –
This is the best place to buy peptides, especially in bulk as they’re in stock with everything most of the time.
Nick Perez –
La mejor compañía de péptidos. lo recomiendo con confianza
Shawn Lachman –
Never had a better shopping experience than with Biotech
Lupe Ortiz –
Customer service lived up to my expectation. It seems their was an issue with their site and they had a product on sale that was not supposed to be on sale. Customer service contacted me to let me know the mix up but that they would honor the sale prices listed this one time.
Ruich Gillet –
The customer service of this company is second to none.
Steven Welsh –
I like that when you can you get a person talking to you and not a machine/robot. Call times are also fast, typically if I need to call in my issue is fixed within 20 minutes.
micheal golovanevsky –
Company is great. Straight forward and to the point with the entire process.
Bobby kohan –
The quality of their products is unmatched
Justin Gellman –
Found you guys from a google search. Peptides are fairly priced and I like that theres discount codes sent out periodically as well.
Eli Reinach –
Peptides are great quality and highest purity I have found.
Cameron Sheron –
My company has been working with Biotech since the start and we never had any issues with them whatsoever. We highly recommend them. Don’t be scared to contact them to work put potential deals or see if they’d have a discount. Like I previously said, i work for a lab company and we like to place big orders. If you need to request anyone Taylor or Danny would be your best bet!
Nick Jaffe –
They never fail to amaze me with the quality of their products
James Adam –
I have bought this product from other suppliers before, but this exceeded all my expectations.
Edwin Marque –
This product works just as described. Follow the storage directions to a T and they’ll last you a while. Just a suggestion I’d make an extra page explaining how it all works as well. I know when I first started out working with peptides I felt a little lost and had to do a lot of research about it. I saw their blog page and it doesn’t seem to have any directions on that (or I did not find it).
Chris Lopez –
Nunca volveré a comprar a otros proveedores. Esta es la compañia perfecta
Chase Nelson –
I never needed a peptide Biotech did not have. They have such a huge range of peptides, it’s crazy
Ciley Kappetta –
This product improved my research considerably.
Rehan Choudhury –
I would recommend this to those working with peptides or to anyone interested in conducting high quality research. They are effective and high quality. I also caution anyone storing them to not freeze and thaw them too much, Has happened to me a few times where even the highest and purest quality peptides just get ruined and then you’re left with a useless peptide.
Ricardo Gonzalez –
Estoy muy satisfecho con mi pedido. Volvere a comprar seguro
Yusuf Bey –
Five stars from me for sure!
Chris O’Connor –
I recommended them to all my colleagues. Their peptides are remarkable and they have them in stock more frequently than other places.
Annie Cheng –
New customer here! I have placed 3 orders so far and they were honoured amazingly, plus they gave me a discount after making my first purchase with them.
Joe Amin –
I bought this in bulk and everything went smoothly. Products came in one big box rather than in separate boxes and deliveries. They seemed pretty well packages as well and I wasn’t worried about any damages.
Eric Chavez –
I will be buying again for sure. Products are fantastic
Noam Belkin –
Blogs are a nice way to understand some of the peptides and what works better with what type of research.
Kevin Harvey –
Very good product
Travis Crom –
Acts faster than any other compound of its kind.
Wayne Robinson –
Unmatched quality, I do see a difference in my work. Also very content with working with them as they fix issues right away and handle it professionally as well.
Chris Anderson –
Products are consistently great. Feel like they changed their shipping company because I used to get packages with a vial or two broken from transit but it’s been smooth sailing for a while.
Nate Adams –
Coworkers rave about the peptides from here and after my research I can see why.
Haiwei Luo –
I usually buy this in bulk and not once I had any problems storing it for a later use. If you do it right it will last a while just like any peptide. But if you store it incorrectly, you’ll be placing more orders than you’d like.
AJ Cardenas –
The shelf life on this one is amazing if you follow the directions correctly
Jose Costa –
Los mejores péptidos que he probado seguro
Cal Goldsman –
Just got my order in!Got it a day before estimated so nice surprise. I was able to start working on my projects earlier as well. I have been shopping here for a few months now and they are one company that sticks to a tight schedule and gets products out as quickly as they come in.
Tony Pipkin –
I will be buying this product again. It performed beautifully in my research
Aria Hillas –
Fantastic product, works very well and the purity speaks for itself. Great find and can’t wait to utilize more of Biotech’s peptides.
Peter Stewart –
A must-try, for sure
Tim Wesler –
This is my all time favorite product. Versatile and when store correctly lasts a while. That’s how you know the quality is equally as great as well. I will say the prices are fair as well. Not the cheapest but better than some other places.
Eddie Kean –
I will be buying again for sure
Jon Bechtel –
Oustanding service and amazing products
Hal Vapnik –
Everything from quality, purity, customer service and delivery is top notch
Ron Anderson –
Quite effective. switched to this from AOD 9604 and I definitely made the right choice.
Kris Ornelas –
My company has switched to BP as a supplier received a month ago and we have not had any issues. We ordered 50 vials of the Frag and received a free Bac water on the house.