Fragment 176-191 (10mg)

(27 customer reviews)


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What Is Fragment 176-191 Peptide?

Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined due to research on animal systems which has proven that Fragment 176-191 enhances fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as the suppression of carbohydrate metabolism, altered sensitivity towards insulin, the promotion of long bone growth, and heightened insulin-like growth factor-1(GF-1) levels. Extensive animal studies have shown that the synthetic fragment enhances the lipolytic effects of hGH without inducing the same side effects. Hence the peptide can be used for anti-obesity treatments.

Fragment 176-191 SPECIFICATIONS

AKA: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

CAS Number: 66004-57-7

Reconstitution: Required

Physiological effects of Frag 176-191

1. Burning of fat and Weight Loss
The fat-burning action of Fragment 176-191 peptide is brought about by increasing the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the fragment upon interaction with ADRB3 directly enhances fat burning in adipose tissue and triggers thermogenesis in skeletal muscle. Genetically modified mice that lack ADRB3 are resistant to the effect of hGH / fragment 176-191.
Studies have shown treatment of fragment 176-191 causes up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide mediates weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there are secondary pathways involved in energy homeostasis that are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.

2. Decrease in Blood Sugar
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions prove that the fragment has the potential to treat prediabetes and type-2 diabetes.

3. Promotion of Cartilage Regeneration
Among other beneficial effects of Fragment 176-191 is the ability of cartilage regeneration. An article published by a Korean group in 2015 revealed that synthetic peptides could bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has highlighted that weekly injection of Fragment 176-191 improve cartilage growth (within laboratory measures) and its co-administration with hyaluronic acid (HA) is more effective. Fragment 176-191, both independently and in combination with HA helps to improve the conditions of osteoarthritis. Thus there is the scope of a better and more beneficial treatment involving this synthetic fragment which will overcome the requirement of surgery.

Safety Studies for frag 176-191

There is a concern regarding the administration of hGH or its derivatives for weight loss. This concern arises from the fact that hGH has shown that exogenous use over extended periods can have significant physiological side effects such as:
– Diabetes
– Edema (swelling)
– Cancer
– Increased resistance to insulin
– Hypertension (high blood pressure)
– Acromegaly.
The Journal of Endocrinology and Metabolism published a study in 2013 which evaluated six research works conducted on the rate and relevance of detrimental effects of Fragment 176-191 peptide. The study is based strictly on the work that has abided by the placebo-controlled, randomized, and double-blinded model of a phase IIb clinical trial with the aim to achieve the highest possible standards of evidence. The study has revealed that both intravenous and oral use of Fragment 176-191 shows no significant alterations compared to placebo control in:
– Physical findings
– Glucose levels
– Laboratory parameters
– Glucose tolerance
– IGF-1 levels
– Insulin sensitivity or
– Rates of adverse events (such as headaches).
The meta-analysis has highlighted that the peptide offers the beneficial effects of hGH treatment without triggering the harmful effects of hGH. The studies speak in favor of regulated use of the synthetic peptide in clinical settings apart from providing insight into the moderation of human growth and development, fat metabolism, and energy homeostasis by the peptide. The studies thus open doors for more comprehensive understanding of energy homeostasis and targeted fat metabolism and ways of manipulating it.
It is important to note that hGH influences muscle growth and development while Fragment 176-191 peptide is strictly catabolic in nature. It triggers lipolysis in adipocytes without bringing about acromegaly or other adverse situations associated with hGH use. Mice models have also shown that the peptide does not promote cellular proliferation.

Research on Fragment 176-191 peptide

The principal areas of research on Fragment 176-191 peptide explore its role in fat metabolism and weight loss. The findings have led to further research on the interesting domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides USA

27 reviews for Fragment 176-191 (10mg)

  1. Ava Lee

    High-quality products & fast shipping!

  2. Aspen Sanders

    I love this company

  3. Charlie Green

    Legit products and quality company. I am very pleased with my experience so far

  4. Ava Lee

    Keep up the good work

  5. Ana White

    This same product goes for about 5 times as much at a compounding pharmacy. 5/5!

  6. Mildred Adamson

    Great products.
    Fast shipping.
    5 stars for everything.

  7. Corbyn Ezra

    Overall great experience with Biotech Peptides. Despite confusion at the start and a little struggle getting one of my prodcuts, they were kind enough to send 2 free-of-charge products along with my missing one!

  8. Odessa Burton

    I have ordered from Biotech Peptides a few times over the last year and they are always super quick delivering! You get text message updates about your order too. If you sign up for the newsletter you get discount codes regularly – Great job guys! Keep it up

  9. Archie Holmes

    Great service and quality stuff what more could you want!!!

  10. Dexter Webb

    USPS lost my package but I was sent a replacement. Free of charge! 4 stars for the delay even though I realize its not your fault/

  11. Tyra Campbell


  12. Deven Krantz

    Lots of information on their website to help find what you need.

  13. Carlo Melwani

    Shipping is fast and reasonably priced.

  14. Kalyn Nicholson

    Everything I’ve ordered has been good quality so far.

  15. Russel Banks

    Prompt service

  16. Stephen Webb

    I’ve placed a bunch of orders with Biotech so far and have never had any issues. A quick turnaround and a good product

  17. Elizabeth Greg

    One of the most affordable places to get peptides! They also have some items on sale here and there. Even better is they offer deals when buying in bulk.

  18. Travis Edrington

    Best customer service and products I have ever had. And I have been a customer with other peptide sites before.

  19. Craig Osborne

    the promotions they send from time to time are great

  20. Halie Martin

    Just made my third order in 2 months! wish the sizes were a bit bigger! But they have good quality peptides.

  21. Richard Wilson

    Been with them for a while. Had got a promtoional email from them so decided to try them out. Their stuff checks out and They’re good at sending our promotions and have frquent sales.

  22. jacob harvey

    Give them two thumbs up

  23. Ben Kennedy

    I have been a loyal cutsomer since July and I can say this is the first time I was sent a broken vial. After inspecting it I’m not sure if it happened when packaging or during transit. I called them and spoke to Danny who was extremly helpful. They did not even ask me for any kid of proof and they just explained to me that I should be getting a new confirmation email with a new order shortly. And due to the headache they even threw in a disocunt code for the next few orders. Such a great company in every way.

  24. PK Lewis

    Like the disocunts they send out periodically!

  25. james messar

    The customer service provided is unmatched. My order came in this morning and even though the box clearly says “FRAGILE” the carrier mishandelded it. All my peptides were broken except a few here and there. I took a picture and emailed it to biotech and immediatly got a responce from Danny. They apologised even though it was not their fault and put in a rush order for me. The tracking number says I should be recieving it by tomorrow morning so fingers crossed.

  26. pete newman

    My peptides showed up in perfect condition. Vials were all in their box and were packaged safley.

  27. Kyle Edwards

    Got a disocunt code for my one year of buying with them!

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