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Fragment 176-191 (10mg)
Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
|Quantity||5 - 9||10 +|
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
What is the Fragment 176-191 peptide?
Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic effects of hGH without inducing the same side effects. Therefore, the peptide may potentially be used for anti-obesity treatments.
AKA: Frag 176-191
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
CAS Number: 66004-57-7
Frag 176-191, Fat Burning and Weight Loss
The fat-burning potential of Frag 176-191 stems from the peptide’s hypothetical ability to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesisscle. Research indicates that genetically modified mice that lack ADRB3 are resistant to the effect of hGH / Fragment 176-191. One experimental study observed that treatment of Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there may be secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.
Frag 176-191 and blood sugar levels
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions suggest that Frag 176-191 has the potential to treat prediabetes and type-2 diabetes.
Frag 176-191 and cartilage regeneration
Experimental research in Frag 176-191 suggests its ability to promote cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has observed that weekly administration of Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) appeared to be even more effective. Fragment 176-191 both independently and in combination with HA may help to improve the conditions of osteoarthritis. Thus there is the reason to include Frag 176-191 in the scope of beneficial treatments which may overcome the requirement of surgery.
Safety Studies in Fragment 176-191
Researchers have attempted to address the concern regarding the administration of hGH or its derivatives for weight loss. This concern arises from the fact that hGH has shown that exogenous use over extended periods can have significant physiological side effects such as:
– Edema (swelling)
– Increased resistance to insulin
– Hypertension (high blood pressure)
The Journal of Endocrinology and Metabolism published a study in 2013 which evaluated six research works conducted on the rate and relevance of detrimental effects of Fragment 176-191 peptide. The study is based strictly on the work that has abided by the placebo-controlled, randomized, and double-blinded model of a phase IIb clinical trial with the aim to achieve the highest possible standards of evidence. The study observed that administration of Fragment 176-191 appeared to exhibit no significant alterations compared to placebo control in:
– Physical findings
– Glucose levels
– Laboratory parameters
– Glucose tolerance
– IGF-1 levels
– Insulin sensitivity or,
– Rates of adverse events (such as headaches)
The meta-analysis has highlighted that the peptide may have the potential to deliver the same beneficial effects of hGH treatment without triggering the harmful effects of hGH. The studies speak in favor of regulated use of the synthetic peptide in clinical settings apart from providing insight into the moderation of human growth and development, fat metabolism, and energy homeostasis by the peptide. The studies thus open doors for more comprehensive understanding of energy homeostasis and targeted fat metabolism and ways of manipulating it.
It is important to note that hGH influences muscle growth and development while Fragment 176-191 peptide is strictly catabolic in nature. Studies indicate the peptide appears to trigger lipolysis in adipocytes without bringing about acromegaly or other adverse situations associated with hGH use. Mice models have also observed that the peptide does not appear to promote cellular proliferation.
Summarization of Research Areas of Frag 176-191
The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research in the domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.
- Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
- Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
- Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7. doi: 10.1152/ajpendo.2000.279.3.E501. PMID: 10950816.
- Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
- Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
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This same product goes for about 5 times as much at a compounding pharmacy. 5/5!
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Overall great experience with Biotech Peptides. Despite confusion at the start and a little struggle getting one of my prodcuts, they were kind enough to send 2 free-of-charge products along with my missing one!
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USPS lost my package but I was sent a replacement. Free of charge! 4 stars for the delay even though I realize its not your fault/
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Shipping is fast and reasonably priced.
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Lots of information on their website to help find what you need. I have even bought or looked into peptides I was never interested in as well interested of it. It’s opened my curiosity to a new realm of research as well. Looking forward to working with topical options too!
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Best customer service and products I have ever had. And I have been a customer with other peptide sites before.
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the promotions they send from time to time are great
Halie Martin –
Just made my third order in 2 months! wish the sizes were a bit bigger! But they have good quality peptides.
Richard Wilson –
Been with them for a while. Had got a promtoional email from them so decided to try them out. Their stuff checks out and They’re good at sending our promotions and have frquent sales.
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Give them two thumbs up
Ben Kennedy –
I have been a loyal cutsomer since July and I can say this is the first time I was sent a broken vial. After inspecting it I’m not sure if it happened when packaging or during transit. I called them and spoke to Danny who was extremly helpful. They did not even ask me for any kid of proof and they just explained to me that I should be getting a new confirmation email with a new order shortly. And due to the headache they even threw in a disocunt code for the next few orders. Such a great company in every way.
PK Lewis –
Like the disocunts they send out periodically!
james messar –
The customer service provided is unmatched. My order came in this morning and even though the box clearly says “FRAGILE” the carrier mishandelded it. All my peptides were broken except a few here and there. I took a picture and emailed it to biotech and immediatly got a responce from Danny. They apologised even though it was not their fault and put in a rush order for me. The tracking number says I should be recieving it by tomorrow morning so fingers crossed.
pete newman –
My peptides showed up in perfect condition. Vials were all in their box and were packaged safley.
Kyle Edwards –
Got a disocunt code for my one year of buying with them!
Alex Avila –
Searched for this product for a while and this is the only company that sells a qualitative and unaltered one.
Taylor Taylor –
This is the best place to buy peptides, especially in bulk as they’re in stock with everything most of the time.
Nick Perez –
La mejor compañía de péptidos. lo recomiendo con confianza
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Never had a better shopping experience than with Biotech
Lupe Ortiz –
Customer service lived up to my expectation. It seems their was an issue with their site and they had a product on sale that was not supposed to be on sale. Customer service contacted me to let me know the mix up but that they would honor the sale prices listed this one time.
Ruich Gillet –
The customer service of this company is second to none.
Steven Welsh –
I like that when you can you get a person talking to you and not a machine/robot. Call times are also fast, typically if I need to call in my issue is fixed within 20 minutes.
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Company is great. Straight forward and to the point with the entire process.
Bobby kohan –
The quality of their products is unmatched
Justin Gellman –
Found you guys from a google search. Peptides are fairly priced and I like that theres discount codes sent out periodically as well.
Eli Reinach –
Peptides are great quality and highest purity I have found.
Cameron Sheron –
My company has been working with Biotech since the start and we never had any issues with them whatsoever. We highly recommend them. Don’t be scared to contact them to work put potential deals or see if they’d have a discount. Like I previously said, i work for a lab company and we like to place big orders. If you need to request anyone Taylor or Danny would be your best bet!
Nick Jaffe –
They never fail to amaze me with the quality of their products
James Adam –
I have bought this product from other suppliers before, but this exceeded all my expectations.
Edwin Marque –
This product works just as described. Follow the storage directions to a T and they’ll last you a while. Just a suggestion I’d make an extra page explaining how it all works as well. I know when I first started out working with peptides I felt a little lost and had to do a lot of research about it. I saw their blog page and it doesn’t seem to have any directions on that (or I did not find it).
Chris Lopez –
Nunca volveré a comprar a otros proveedores. Esta es la compañia perfecta
Chase Nelson –
I never needed a peptide Biotech did not have. They have such a huge range of peptides, it’s crazy
Ciley Kappetta –
This product improved my research considerably.
Rehan Choudhury –
I would recommend this to those working with peptides or to anyone interested in conducting high quality research. They are effective and high quality. I also caution anyone storing them to not freeze and thaw them too much, Has happened to me a few times where even the highest and purest quality peptides just get ruined and then you’re left with a useless peptide.
Ricardo Gonzalez –
Estoy muy satisfecho con mi pedido. Volvere a comprar seguro
Yusuf Bey –
Five stars from me for sure!
Chris O’Connor –
I recommended them to all my colleagues. Their peptides are remarkable and they have them in stock more frequently than other places.
Annie Cheng –
New customer here! I have placed 3 orders so far and they were honoured amazingly, plus they gave me a discount after making my first purchase with them.
Joe Amin –
I bought this in bulk and everything went smoothly. Products came in one big box rather than in separate boxes and deliveries. They seemed pretty well packages as well and I wasn’t worried about any damages.
Eric Chavez –
I will be buying again for sure. Products are fantastic
Noam Belkin –
Blogs are a nice way to understand some of the peptides and what works better with what type of research.
Kevin Harvey –
Very good product
Travis Crom –
Acts faster than any other compound of its kind.
Wayne Robinson –
Unmatched quality, I do see a difference in my work. Also very content with working with them as they fix issues right away and handle it professionally as well.
Chris Anderson –
Products are consistently great. Feel like they changed their shipping company because I used to get packages with a vial or two broken from transit but it’s been smooth sailing for a while.
Nate Adams –
Coworkers rave about the peptides from here and after my research I can see why.
Haiwei Luo –
I usually buy this in bulk and not once I had any problems storing it for a later use. If you do it right it will last a while just like any peptide. But if you store it incorrectly, you’ll be placing more orders than you’d like.
AJ Cardenas –
The shelf life on this one is amazing if you follow the directions correctly
Jose Costa –
Los mejores péptidos que he probado seguro
Cal Goldsman –
Just got my order in!Got it a day before estimated so nice surprise. I was able to start working on my projects earlier as well. I have been shopping here for a few months now and they are one company that sticks to a tight schedule and gets products out as quickly as they come in.
Tony Pipkin –
I will be buying this product again. It performed beautifully in my research
Aria Hillas –
Fantastic product, works very well and the purity speaks for itself. Great find and can’t wait to utilize more of Biotech’s peptides.
Peter Stewart –
A must-try, for sure
Tim Wesler –
This is my all time favorite product. Versatile and when store correctly lasts a while. That’s how you know the quality is equally as great as well. I will say the prices are fair as well. Not the cheapest but better than some other places.
Eddie Kean –
I will be buying again for sure
Jon Bechtel –
Oustanding service and amazing products
Hal Vapnik –
Everything from quality, purity, customer service and delivery is top notch
Ron Anderson –
Quite effective. switched to this from AOD 9604 and I definitely made the right choice.
Kris Ornelas –
My company has switched to BP as a supplier received a month ago and we have not had any issues. We ordered 50 vials of the Frag and received a free Bac water on the house.