AOD 9604 SPECIFICATIONS
Molecular Formula: C78H123N23O23S2
Molecular Weight: 1815.1 g/mol
PubChem: CID 16131447
CAS Number: 386264-39-7
What is AOD 9604 peptide?
AOD 9604 is a modified peptide initially developed for the treatment of obesity. It modifies the peptide fragment 176-191 of human growth hormone (HGH). Interestingly, the mode of action of AOD 9604 is restricted to promoting lipolysis in the body, making it a popular choice for treating obesity. The peptide does not affect levels of insulin or IGF1 in the body. Therefore, using AOD 9604 does not trigger a clinical risk of developing diabetes or intolerance towards glucose. Also, because it is structurally similar to HGH, it does not induce immunogenic reactions and is immunologically safe.
AOD 9604 and Obesity
AOD 9604 has been brought into clinical trials with the objective of targeting obesity using a peptide similar to HGH. Phase IIb clinical trials conducted on 300 obese individuals in Australia have shown that the peptide has resulted in consistent weight loss over 12 weeks when administered once daily. The rate of weight reduction in patients undergoing treatment has been greatly compared to the placebo cohort, and weight loss has been steady over the entire study period. This observation indicated that the peptide is unlikely to generate resistance, and thus continued treatment would result in a pronounced effect.
Researchers have worked on mice models to explore the underlying mechanism of AOD 9604. An initial hypothesis has proposed that AOD 9604 binds and activates β-3-adrenergic receptors, which are present on the surface of white adipose tissues. Upon binding to the cognate receptors, the peptide triggers downstream signaling, which mobilizes the fat cells from storage mode to a usable state by enhancing the rate of metabolism. Interestingly, mice genetically mutated in β-3-adrenergic receptors also have undergone fat loss, possibly through apoptosis of the white adipose tissues.
AOD 9604 and Cardiac Disease
AOD 9604 improves cardiac health indirectly by mobilizing fat and reducing obesity. The peptide thus reduces the chances of cardiac disease caused by obesity. Interestingly, apart from its principal function of decreasing the fat burden in the body, there are other mechanisms by which the drug improves cardiac conditions. These pathways are independent of β-3-adrenergic receptors and improve general metabolism, leading to improved cardiac health. Drugs are often known to induce various independent positive effects on the body. Some drugs such as acipimox and pioglitazone are known to improve metabolism without directly influencing fat reduction.
Joint Pain and Function
Improvement of cartilage growth has always been a persistent clinical challenge. Studies involving AOD9-604 have demonstrated that it helps to address this issue. Research have shown that introducing the peptide directly into arthritic joints in rats improves pain management, decreases movement disability, and enhances general quality of life. AOD 9604 can promote the growth of cartilage tissue in the arthritic joints, but the effect is pronounced in conjunction with other existing therapies. Clinical examination and microscopic cartilage structure analysis in the affected joints have shown positive results upon the AOD 9604 treatment of osteoarthritis. This highlights that application of this peptide can be beneficial in both the prevention and treatment of the above condition.
The peptide shows consistently minimal adverse effects and high bioavailability in the subcutaneous region of mice. However, the dosage administered to mice (per kg) cannot be scaled up for human administration.
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