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AOD 9604 (5mg)
$44.00
AOD 9604 peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
| Quantity | 5 - 9 | 10 + |
|---|---|---|
| Discount | 5% | 10% |
| Price | $41.80 | $39.60 |
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Description
AOD 9604 Peptide
AOD 9604 is a modified peptide initially developed as an offshoot in obesity research. It modifies the peptide Fragment 176-191 of the growth hormone hGH by adding a tyrosine residue to the N-terminus. The proposed mode of action of AOD 9604 has been suggested by researchers to be restricted to promoting lipolysis, thus linking the synthetic compound to obesity research.[1] The peptide does not appear to affect levels of insulin or IGF1 in studies thus far; therefore, it does not appear to trigger diabetes development or induce glucose intolerance in test models, though further studies are necessary to explore this aspect.[2]
Specifications
Other Known Titles: AOD-9604
Molecular Formula: C78H123N23O23S2
Molecular Weight: 1815.1 g/mol
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
AOD 9604 Research
AOD 9604 Structure
Scientists hypothesize that different parts of the hGH molecule may possess different properties and induce different effects in test models.[3] It has been suggested that only the last 15 amino acids may mediate any fat-burning potential of the hormone. The fragment was initially named hGH 177-191 and was subsequently modified by adding tyrosine to create AOD 9401, potentially to help stabilize the molecule. This modification led to the production of a 16-amino acid fragment called AOD 9604.[4] Interestingly, the researchers comment, “AOD 9604 does not interact with the hGH receptor.” This modification may have made the hGH Fragment 176-191 relatively more stable than other peptides.
AOD 9604 Mechanism of Action
AOD 9604 has mainly been studied in murine models, and significant experiments have involved relatively large amounts of AOD 9604.[5] These experiments reportedly resulted in a 50% reduction in weight following exposure to the research models. However, it is important to note that the fragment appears to lack any other associated action of hGH, such as a potential increase of IGF-1 (insulin-like growth factor-1), insulin resistance, or cell proliferation. Therefore, the compound may not possess the potential muscle-preserving and anabolic action typically associated with growth hormones. Nevertheless, it appears that AOD 9604 may stimulate weight loss through mechanisms similar to hGH, as it may trigger various cellular pathways that might lead to the release of fatty acids from adipose cells.
Additionally, researchers have posited that the peptide may affect the activity of lipases, a group of enzymes that prevent the return of fat to adipose tissues.[6] It is worth noting that AOD 9604 does not appear to affect natural hGH production and does not appear to act as a growth hormone secretagogue. Moreover, it does not appear to impact hunger hormone signaling to either increase or decrease appetite. Murine models comparing AOD 9604 and hGH have reported different outcomes in lean and obese cases.[4] In lean murine models, hGH appears to increase lean body mass, whereas AOD 9604 or a placebo did not appear to produce the same action. Hence, researchers have speculated that AOD 9604 may not be effective in increasing the size of muscle cells and contributing to muscle hypertrophy. However, in obese murine models, both hGH and AOD 9604 appear to exert a weight loss potential. The scientists also commented that there was an apparent 40% reduction in adipose tissue in the hGH group compared to 28% with AOD 9604.
Therefore, experiments suggest that AOD 9604 may hold reduced potential compared to hGH in stimulating the release of fats from adipose cells.[7] The researchers also posit that “the lipolytic actions of both hGH and AOD 9604 are not mediated directly through the β3-AR although both compounds increase β3-AR expression, which may subsequently contribute to enhanced lipolytic sensitivity.” Growth hormone likely promotes a greater release of fats from adipose cells due to its proposed impact on insulin resistance. By reducing glucose uptake, it may force cells to potentially utilize more fat instead. In contrast, the fragment AOD 9604 does not appear to increase insulin resistance. Additionally, anecdotal data suggests that AOD 9604 may potentially offer some impact, including modest improvements in cholesterol levels and insulin sensitivity, but it is yet to be confirmed by murine models.
AOD 9604 and Obesity
AOD 9604 has been brought into clinical trials with the objective of targeting obesity using a peptide similar to hGH. Phase 2b clinical trials conducted on 300 obese test subjects in Australia observed that the peptide appeared to result in consistent weight loss over 12 weeks when introduced once daily.[8] The rate of weight reduction in test subjects was consistently compared to the placebo cohort, and weight loss appeared to hold steady over the entire study period. This observation indicated that the peptide is unlikely to generate resistance, and thus continued influence of the peptide might result in a pronounced effect. Study in this area is ongoing. Researchers have also utilized mice models to explore the underlying mechanism of AOD 9604.
An initial hypothesis proposed that AOD 9604 may bind and activate β-3-adrenergic receptors, which are present on the surface of white adipose tissues. Upon binding to the cognate receptors, the peptide may trigger downstream signaling, which may mobilize the fat cells from storage mode to a usable state by enhancing the rate of metabolism. Interestingly, mice genetically mutated in β-3-adrenergic receptors underwent fat loss, possibly through apoptosis of the white adipose tissues.
AOD 9604 and Cardiac Disease
AOD 9604 may host the potential to improve cardiac function indirectly by mobilizing fat and reducing obesity. The peptide may reduce the chances of cardiac disease induced by obesity. Apart from its proposed principal function of decreasing fat burden, research teams have suggested other mechanisms by which the peptide might improve cardiac conditions. These pathways are independent of β-3-adrenergic receptors and appear to improve general metabolism, improving cardiac function.[9]
AOD 9604 and Joints
Research suggests that AOD 9604 may influence arthritic joints in rabbits, and may have contributed to an improvement in pain perception and decreased movement disability.[10] Researchers have speculated that AOD 9604 may promote the growth of cartilage tissue in the arthritic joints but have yet to fully investigate this hypothesis. Experimental examination and microscopic cartilage structure analysis in affected joints have indicated positive results upon AOD 9604 influence in osteoarthritis test subjects.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Ng, F. M., Sun, J., Sharma, L., Libinaka, R., Jiang, W. J., & Gianello, R. (2000). Metabolic studies of a synthetic lipolytic domain (AOD 9604) of human growth hormone. Hormone research, 53(6), 274–278. https://doi.org/10.1159/000053183
- Cox, H. D., Smeal, S. J., Hughes, C. M., Cox, J. E., & Eichner, D. (2015). Detection and in vitro metabolism of AOD 9604. Drug testing and analysis, 7(1), 31–38. https://doi.org/10.1002/dta.1715
- Ng, F. M., Jiang, W. J., Gianello, R., Pitt, S., & Roupas, P. (2000). Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats. Journal of molecular endocrinology, 25(3), 287-298.
- Heffernan, M. A., Thorburn, A. W., Fam, B., Summers, R., Conway-Campbell, B., Waters, M. J., & Ng, F. M. (2001). Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 25(10), 1442–1449. https://doi.org/10.1038/sj.ijo.0801740
- Ng, F. M., Sun, J., Sharma, L., Libinaka, R., Jiang, W. J., & Gianello, R. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone research, 53(6), 274–278. https://doi.org/10.1159/000053183
- Kopchick, J. J., Berryman, D. E., Puri, V., Lee, K. Y., & Jorgensen, J. O. (2020). The effects of growth hormone on adipose tissue: old observations, new mechanisms. Nature Reviews Endocrinology, 16(3), 135-146.
- Heffernan, M., Summers, R. J., Thorburn, A., Ogru, E., Gianello, R., Jiang, W. J., & Ng, F. M. (2001). The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice. Endocrinology, 142(12), 5182-5189.
- Bray, G. A., & Greenway, F. L. (2007). Pharmacological treatment of the overweight patient. Pharmacological reviews, 59(2), 151–184. https://doi.org/10.1124/pr.59.2.2
- Heffernan, M., Summers, R. J., Thorburn, A., Ogru, E., Gianello, R., Jiang, W. J., & Ng, F. M. (2001). The effects of human GH and its lipolytic fragment (AOD 9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology, 142(12), 5182–5189. https://doi.org/10.1210/endo.142.12.8522
- Kwon, D. R., & Park, G. Y. (2015). Effect of Intra-articular Injection of AOD 9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Annals of clinical and laboratory science, 45(4), 426–432.
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This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
| Brand | Biotech Peptides |
|---|
63 reviews for AOD 9604 (5mg)
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Ignatiy Leyton –
thanks for the free BAC water! happy customer here – Ignatiy
Jake Thomas –
A+ for the professional packaging and overall reliability. Products are also top notch…
Logan Watson –
I cant say enough about the selection of peptides here. Ive ordered multiple times and it’s always on time. Customer service has been very helpful so far.
Milo Ramos –
Will order from here again. 5mg is the perfect amount so it doesn’t end up sitting in your fridge going bad.
Aurora Clark –
Highly efficient peptide. Works really well with my research. Am curious to see how the other peptides I bought will react. On another note i did also enjoy the blog and the information it had. Made me curious about a few other peptides I had not looked into much.
Callum Morton –
Great company. Ordered from here four times now. The peptides are of high quality. Shipping is fast and reliable. There are also many different payment options.
Fallon Swift –
I find it very useful that the company offers different ways of payment and I always receive my parcel very quickly.
Harlow Pham –
The product is very effective and looks as how it is described. The vials were the perfect size but careful with dealing with them, the glass is extremely fragile.
Alexis Paytas –
I received a broken vial but a replacement was sent out right away after I reached out with no questions asked. Got the peptides the next day and did not have to pay extra for anything. They even threw in a Bac water on them for my trouble!!
Oliver Singh –
Fantastic Company. I have tried many other peptide companies and was disappointed. However, the quality here is top class. Whatever it says on the vial is in the vial.
Mai Yang –
Out of all the peptide stores I’ve used I have found this one to be the best. Great products, fast delivery, and superb support when you need it.
Koleen Farrugia –
Great products — not like some of the cheap alternatives on the market that don’t mix properly. Smooth service and speedy delivery. Highly recommended.
Sarah Diaz –
Great team. Speedy, helpful knowledgeable, and trustworthy service.
Trevor Miles –
Fantastic service and great value for money considering the quality.
Vanessa Walker –
Professional customer service! They have refunded me my extra payment for next day delivery, because of a small misunderstanding
Jack Petty –
I had a great experience with my first purchase from Biotech pepides. The order arrived safley but I wish they had better packaging. I’d order again tho
Lord Shmup –
I really love this company but I’d make a suggestion. I think it would be good to incorporate more rewards for loyal customers and repeat buyers
John Rowekamp John Rowekamp –
Transactions were completed in a matter of minutes. Not a hassle at all, looking forward to receiving the purchases.
Galina Ryabova –
Fast delivery and simple purchase. I haven’t gotten around to evaluating the quality of the goods yet. I have heard through the grape vine that they have some very nice products that have shown a difference in many others researches.
David Shwartz –
This was recommended to me by a person I work with and since I started purchasing from you guys I never switched suppliers again
Nathanael R. Odom –
Customer service is as great as they said. I ran into a problem this week with the company(shocker). They sent me only three of my products instead of the five that I ordered. That’s a problem. I got ahold of one of their representatives and not going to lie I was really frustrated. The guy on the other end understood why and explained this is not a common occurrence at all. Nevertheless, they made sure to take care of it right away and refunded me for the missing products as well as give me a discount for the next purchase. I got my missing products within a few days. The whole process was a headache but they made up for it. I’m going to give them a try again and hopefully no more mishaps.
Alex Morales –
Been purchasing products from Biotech since August! hasn’t seemed to fail me yet
Joanna Marszalek –
Taylor is awesome, always helpful, and knows their stuff!! The product was out of stock and they were able to recommend a peptide that’s a substitute for the one I needed.
Shiv Patel –
Had a small issue with getting the products in time due to traveling all the way to India. I am happy to report that the peptides were no ruined in the process. Packaged perfectly
Leo Murphy –
Always amazed with the quality. Purity checks out everytime. Peptides are as true as they can be.
Harry Gagnon –
Have encountered a few times where peptides were broken but didn’t say anything as it was just one vial out of the bunch so it didn’t effect me too much. This morning when I opened my package almost all the peptide were shattered. Must have been a rough delivery process. Had to contact them but was not worried as i’ve seen some remarks about this happening to others. They didn’t even ask me for proof, Taylor just asked for the order number and confirmed the address.
Emily Roy –
Just put in my order with them again. I have been shopping with them for the past year. I have not had one bad experience with them. Really good company!
Christopher Adams –
They are a decent site to get peptides. Usually in stock of everything you need. Did notice the abundance of peptides as well. Haven’t seen a site with this many products in stock before.
Susan Stivalo –
Taylor is great at what they do. In my bundle I put in the wrong peptide. Sent a quick email to Taylor and they were able to make the corrections happen.
Omar Sanchez –
Got 3 free bac waters instead of the 2 that were promised! Nice surprise
Ken Walters –
Taylor was amazing at answering all questions and handleing all my needs. They knew all the peptides and orders which was refreshing as you call some other places and the employees don’t know much. Customer service can’t be beat.
Clay Thomas –
You get what you pay for with them which is great quality peptides and great service!
Amber Wilson –
Quick and easy check out. Already got an email that my orders been shipped out!
Landon Powell –
Had no issues with shipment. Customs could usually be an issue out here in Canada but was a smooth experience and I got everything in a timely manner.
Akito Taylor –
Products were great and showed up in perfect condition.
Guerra Harold –
They are always in stock of the peptides I need. Have seen them be out of stock just a few times however their restock time is fast.
Alex castro –
I place orders constantly for our lab. Biotech is truly a reliable and great peptide supplier. We have been working with them for about 8 months now, since the end of 2021. Maybe its becuase we are loacted in Southern California as well but peptides have come in perfect condition and we have not experinced any significant delays thus far.
Nico Trujillo –
Prices are the best I found for the quality. It just seems like the prices for everything just keep going up but I noticed Biotech didn’t go crazy like some other places.
Bruce Zacuto –
Have tried various sites and Biotech is my favorite by far.
Alec Cannold –
I had a great experince. Products I needed were in stock. Check out was standard and I was glad they took many forms of payment!
Yarden Mazor –
Love the company, get what you pay for
Ajay Cheema –
Very happy my products came in on time and in perfect condition even with the major heat wave.
Shane Baumel –
Storage life is great, just follow the directions and you should be good for the time being. I wouldn’t worry too much about it as it’s pretty easy to store it correctly if you literally just follow the directions of what to do.
Adam Bilmes –
Company is great, Peptides are even better.
Ziad Hijazi –
I had placed a rushed order for my peptides and they arrived on time! No peptides were missing and they even through in a free Bac water on the house. Absolutely love their service and work ethic.
Russell posin –
Amazing peptide quality
Jon Walters –
The researchers at my lab love the peptides from biotech! We’ve made it out sole provider. If a shipping issue or a product is missing they make it an easy and stress free process to get a hold of them AND they handle it quickly. I have never had to call twice to fix an issue, they get the job done right away the correct way unlike so many other companies!
Hiep Dang –
Appreciate the frequent emails and promos!
Hal Louis –
Peptides met all expectation in regards to quality and pureness!
Brandon Nguyen –
Not too difficult to store, just need to follow directions and you’re good to go. Seems like people have issues with it sometimes but even the call center here will tell you just follow the exact directions and you should be good.
Jason Sirak –
Get a sense of quality over quantity with them. Did notice they’re adding some new peptides to the site as well though!!
Gabby Helton –
I was recommened here by a work friend, can’t wait to test these peptides out, I’ve been told my research will see some good changes.
Vic Carrizalez –
Swicthed over to biotech after hearing great stuff about the service and peptides. They don’t dissapoint!
Yu Ning –
Very pure, very high end stuff
Andy Peters –
Got the products shipped all the way here in Canada. Peptides have arrived safley and in great condition. Wouldn’t say they came from the US.
George T. –
I wish their sales were a bit better. Feel like the discount doesn’t do much of a difference on the end total.
Karly Lucht –
Got my stuff within 48 hours of ordering.
Adam Jewell –
Had no issues getting them out here in Canada! In the past with other companies its taken a few weeks to get them in but only took a little less than a week with biotech.
AL Armstrong –
Would purchase from them again!
Yvonne Mercedes –
Got my package when estimated and everything inside was properly protected. Box even has fragile written on it on a red tag so nice to know they’re doing all they can to prevent anything from going wrong.
Travis Olinger –
Was scared the peptides could be effected by the heat but everything looks good! Peptides came as safely as they possibly could. Heat did not seem to do anything to it and they work as they typically should.
Amy Trahan –
Discounts are great, and they give them pretty often. It’s also pretty nice that they don’t expire for a while so you can use it up till a few months. I also noticed I can use it on sale peptides as well which is always great.
Teria Harris –
I was a bit concerned when initially ordering. I must say the products are fantastic! I am also very impressed with how quickly I received them. This is the new spot for all my peptide needs.