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AOD 9604 (5MG)
HPLC - AOD 9604
Mass Spectrometry - AOD 9604
Certificate of Analysis - AOD 9604

AOD 9604 (5mg)

(62 customer reviews)

$43.00

AOD 9604 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$40.85$38.70
Orders over $300 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
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SKU: AOD9604-5mg Category:

Description

What is the AOD 9604 peptide?

AOD 9604 is a modified peptide initially developed for the treatment of obesity. It modifies the peptide fragment 176-191 of human growth hormone (HGH). Interestingly, the mode of action of AOD 9604 is restricted to promoting lipolysis in the body, making it a potential treatment for obesity[1]. The peptide does not appear to affect levels of insulin or IGF1 in the body. Therefore, it is possible that AOD 9604 may not trigger a clinical risk of developing diabetes or intolerance towards glucose. Also, because it is structurally similar to HGH, it is unlikely to induce immunogenic reactions and appears to be immunologically safe under study[2].

Specifications

AKA: AOD-9604

Molecular Formula: C78H123N23O23S2

Molecular Weight: 1815.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

PubChem: CID 16131447

CAS Number: 386264-39-7

Reconstitution: Required

Research

AOD 9604 and Obesity
AOD 9604 has been brought into clinical trials with the objective of targeting obesity using a peptide similar to HGH. Phase IIb clinical trials conducted on 300 obese individuals in Australia, observing that the peptide has resulted in consistent weight loss over 12 weeks when administered once daily[3]. The rate of weight reduction in patients undergoing treatment has been greatly compared to the placebo cohort, and weight loss has been steady over the entire study period. This observation indicated that the peptide is unlikely to generate resistance, and thus continued treatment would result in a pronounced effect.
Researchers have worked on mice models to explore the underlying mechanism of AOD 9604. An initial hypothesis has proposed that AOD 9604 binds and activates ฮฒ-3-adrenergic receptors, which are present on the surface of white adipose tissues. Upon binding to the cognate receptors, the peptide may trigger downstream signaling, which mobilizes the fat cells from storage mode to a usable state by enhancing the rate of metabolism. Interestingly, mice genetically mutated in ฮฒ-3-adrenergic receptors also have undergone fat loss, possibly through apoptosis of the white adipose tissues.

AOD 9604 and Cardiac Disease
AOD 9604 has the potential to improve cardiac health indirectly by mobilizing fat and reducing obesity. The peptide may therefore reduce the chances of cardiac disease caused by obesity. Interestingly, apart from its principal function of decreasing the fat burden in the body, there may be other mechanisms by which the peptide improves cardiac conditions. These pathways are independent of ฮฒ-3-adrenergic receptors and improve general metabolism, leading to improved cardiac health[4]. Peptides are often known to induce various independent positive effects on the body. Some medications such as acipimox and pioglitazone are known to improve metabolism without directly influencing fat reduction.

Joint Pain and Function
Improvement of cartilage growth has always been a persistent clinical challenge. Studies involving AOD 9604 have demonstrated that it helps to address this issue. Research suggests that introducing the peptide directly into arthritic joints in rabbits may improve pain management, decrease movement disability, and enhance general quality of life[5]. AOD 9604 can promote the growth of cartilage tissue in the arthritic joints, but the effect is pronounced in conjunction with other existing therapies. Clinical examination and microscopic cartilage structure analysis in the affected joints have shown positive results upon the AOD 9604 treatment of osteoarthritis. This highlights that application of this peptide has the potential to be beneficial in both the prevention and treatment of the above condition.
Research on the peptide shows consistently minimal adverse effects and high bioavailability in the subcutaneous region of mice. However, the dosage administered to mice (per kg) cannot be scaled up for human administration.

References

  1. Ng, F. M., Sun, J., Sharma, L., Libinaka, R., Jiang, W. J., & Gianello, R. (2000). Metabolic studies of a synthetic lipolytic domain (AOD 9604) of human growth hormone. Hormone research, 53(6), 274โ€“278. https://doi.org/10.1159/000053183
  2. Cox, H. D., Smeal, S. J., Hughes, C. M., Cox, J. E., & Eichner, D. (2015). Detection and in vitro metabolism of AOD 9604. Drug testing and analysis, 7(1), 31โ€“38. https://doi.org/10.1002/dta.1715
  3. Bray, G. A., & Greenway, F. L. (2007). Pharmacological treatment of the overweight patient. Pharmacological reviews, 59(2), 151โ€“184. https://doi.org/10.1124/pr.59.2.2
  4. Heffernan, M., Summers, R. J., Thorburn, A., Ogru, E., Gianello, R., Jiang, W. J., & Ng, F. M. (2001). The effects of human GH and its lipolytic fragment (AOD 9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology, 142(12), 5182โ€“5189. https://doi.org/10.1210/endo.142.12.8522
  5. Kwon, D. R., & Park, G. Y. (2015). Effect of Intra-articular Injection of AOD 9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Annals of clinical and laboratory science, 45(4), 426โ€“432.
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only.ย  Human or animal use and/or consumption is strictly prohibited by law.ย  Only qualified and licensed professionals should handle these products.ย  Any information found on Biotech Peptides is strictly for educational purposes only.ย  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

62 reviews for AOD 9604 (5mg)

  1. Ignatiy Leyton –

    thanks for the free BAC water! happy customer here – Ignatiy

  2. Jake Thomas –

    A+ for the professional packaging and overall reliability. Products are also top notch…

  3. Logan Watson –

    I cant say enough about the selection of peptides here. Ive ordered multiple times and it’s always on time. Customer service has been very helpful so far.

  4. Milo Ramos –

    Will order from here again. 5mg is the perfect amount so it doesn’t end up sitting in your fridge going bad.

  5. Aurora Clark –

    Highly efficient peptide. Works really well with my research. Am curious to see how the other peptides I bought will react. On another note i did also enjoy the blog and the information it had. Made me curious about a few other peptides I had not looked into much.

  6. Callum Morton –

    Great company. Ordered from here four times now. The peptides are of high quality. Shipping is fast and reliable. There are also many different payment options.

  7. Fallon Swift –

    I find it very useful that the company offers different ways of payment and I always receive my parcel very quickly.

  8. Harlow Pham –

    The product is very effective and looks as how it is described. The vials were the perfect size but careful with dealing with them, the glass is extremely fragile.

  9. Alexis Paytas –

    I received a broken vial but a replacement was sent out right away after I reached out with no questions asked. Got the peptides the next day and did not have to pay extra for anything. They even threw in a Bac water on them for my trouble!!

  10. Oliver Singh –

    Fantastic Company. I have tried many other peptide companies and was disappointed. However, the quality here is top class. Whatever it says on the vial is in the vial.

  11. Mai Yang –

    Out of all the peptide stores I’ve used I have found this one to be the best. Great products, fast delivery, and superb support when you need it.

  12. Koleen Farrugia –

    Great products โ€” not like some of the cheap alternatives on the market that donโ€™t mix properly. Smooth service and speedy delivery. Highly recommended.

  13. Sarah Diaz –

    Great team. Speedy, helpful knowledgeable, and trustworthy service.

  14. Trevor Miles –

    Fantastic service and great value for money considering the quality.

  15. Vanessa Walker –

    Professional customer service! They have refunded me my extra payment for next day delivery, because of a small misunderstanding

  16. Jack Petty –

    I had a great experience with my first purchase from Biotech pepides. The order arrived safley but I wish they had better packaging. I’d order again tho

  17. Lord Shmup –

    I really love this company but I’d make a suggestion. I think it would be good to incorporate more rewards for loyal customers and repeat buyers

  18. John Rowekamp John Rowekamp –

    Transactions were completed in a matter of minutes. Not a hassle at all, looking forward to receiving the purchases.

  19. Galina Ryabova –

    Fast delivery and simple purchase. I haven’t gotten around to evaluating the quality of the goods yet. I have heard through the grape vine that they have some very nice products that have shown a difference in many others researches.

  20. David Shwartz –

    This was recommended to me by a person I work with and since I started purchasing from you guys I never switched suppliers again

  21. Nathanael R. Odom –

    Customer service is as great as they said. I ran into a problem this week with the company(shocker). They sent me only three of my products instead of the five that I ordered. That’s a problem. I got ahold of one of their representatives and not going to lie I was really frustrated. The guy on the other end understood why and explained this is not a common occurrence at all. Nevertheless, they made sure to take care of it right away and refunded me for the missing products as well as give me a discount for the next purchase. I got my missing products within a few days. The whole process was a headache but they made up for it. I’m going to give them a try again and hopefully no more mishaps.

  22. Alex Morales –

    Been purchasing products from Biotech since August! hasn’t seemed to fail me yet

  23. Joanna Marszalek –

    Taylor is awesome, always helpful, and knows their stuff!! The product was out of stock and they were able to recommend a peptide that’s a substitute for the one I needed.

  24. Shiv Patel –

    Had a small issue with getting the products in time due to traveling all the way to India. I am happy to report that the peptides were no ruined in the process. Packaged perfectly

  25. Leo Murphy –

    Always amazed with the quality. Purity checks out everytime. Peptides are as true as they can be.

  26. Harry Gagnon –

    Have encountered a few times where peptides were broken but didn’t say anything as it was just one vial out of the bunch so it didn’t effect me too much. This morning when I opened my package almost all the peptide were shattered. Must have been a rough delivery process. Had to contact them but was not worried as i’ve seen some remarks about this happening to others. They didn’t even ask me for proof, Taylor just asked for the order number and confirmed the address.

  27. Emily Roy –

    Just put in my order with them again. I have been shopping with them for the past year. I have not had one bad experience with them. Really good company!

  28. Christopher Adams –

    They are a decent site to get peptides. Usually in stock of everything you need. Did notice the abundance of peptides as well. Haven’t seen a site with this many products in stock before.

  29. Susan Stivalo –

    Taylor is great at what they do. In my bundle I put in the wrong peptide. Sent a quick email to Taylor and they were able to make the corrections happen.

  30. Omar Sanchez –

    Got 3 free bac waters instead of the 2 that were promised! Nice surprise

  31. Ken Walters –

    Taylor was amazing at answering all questions and handleing all my needs. They knew all the peptides and orders which was refreshing as you call some other places and the employees don’t know much. Customer service can’t be beat.

  32. Clay Thomas –

    You get what you pay for with them which is great quality peptides and great service!

  33. Amber Wilson –

    Quick and easy check out. Already got an email that my orders been shipped out!

  34. Landon Powell –

    Had no issues with shipment. Customs could usually be an issue out here in Canada but was a smooth experience and I got everything in a timely manner.

  35. Akito Taylor –

    Products were great and showed up in perfect condition.

  36. Guerra Harold –

    They are always in stock of the peptides I need. Have seen them be out of stock just a few times however their restock time is fast.

  37. Alex castro –

    I place orders constantly for our lab. Biotech is truly a reliable and great peptide supplier. We have been working with them for about 8 months now, since the end of 2021. Maybe its becuase we are loacted in Southern California as well but peptides have come in perfect condition and we have not experinced any significant delays thus far.

  38. Nico Trujillo –

    Prices are the best I found for the quality. It just seems like the prices for everything just keep going up but I noticed Biotech didn’t go crazy like some other places.

  39. Bruce Zacuto –

    Have tried various sites and Biotech is my favorite by far.

  40. Alec Cannold –

    I had a great experince. Products I needed were in stock. Check out was standard and I was glad they took many forms of payment!

  41. Yarden Mazor –

    Love the company, get what you pay for

  42. Ajay Cheema –

    Very happy my products came in on time and in perfect condition even with the major heat wave.

  43. Shane Baumel –

    Storage life is great, just follow the directions and you should be good for the time being. I wouldn’t worry too much about it as it’s pretty easy to store it correctly if you literally just follow the directions of what to do.

  44. Adam Bilmes –

    Company is great, Peptides are even better.

  45. Ziad Hijazi –

    I had placed a rushed order for my peptides and they arrived on time! No peptides were missing and they even through in a free Bac water on the house. Absolutely love their service and work ethic.

  46. Russell posin –

    Amazing peptide quality

  47. Jon Walters –

    The researchers at my lab love the peptides from biotech! We’ve made it out sole provider. If a shipping issue or a product is missing they make it an easy and stress free process to get a hold of them AND they handle it quickly. I have never had to call twice to fix an issue, they get the job done right away the correct way unlike so many other companies!

  48. Hiep Dang –

    Appreciate the frequent emails and promos!

  49. Hal Louis –

    Peptides met all expectation in regards to quality and pureness!

  50. Brandon Nguyen –

    Not too difficult to store, just need to follow directions and you’re good to go. Seems like people have issues with it sometimes but even the call center here will tell you just follow the exact directions and you should be good.

  51. Jason Sirak –

    Get a sense of quality over quantity with them. Did notice they’re adding some new peptides to the site as well though!!

  52. Gabby Helton –

    I was recommened here by a work friend, can’t wait to test these peptides out, I’ve been told my research will see some good changes.

  53. Vic Carrizalez –

    Swicthed over to biotech after hearing great stuff about the service and peptides. They don’t dissapoint!

  54. Yu Ning –

    Very pure, very high end stuff

  55. Andy Peters –

    Got the products shipped all the way here in Canada. Peptides have arrived safley and in great condition. Wouldn’t say they came from the US.

  56. George T. –

    I wish their sales were a bit better. Feel like the discount doesn’t do much of a difference on the end total.

  57. Karly Lucht –

    Got my stuff within 48 hours of ordering.

  58. Adam Jewell –

    Had no issues getting them out here in Canada! In the past with other companies its taken a few weeks to get them in but only took a little less than a week with biotech.

  59. AL Armstrong –

    Would purchase from them again!

  60. Yvonne Mercedes –

    Got my package when estimated and everything inside was properly protected. Box even has fragile written on it on a red tag so nice to know they’re doing all they can to prevent anything from going wrong.

  61. Travis Olinger –

    Was scared the peptides could be effected by the heat but everything looks good! Peptides came as safely as they possibly could. Heat did not seem to do anything to it and they work as they typically should.

  62. Amy Trahan –

    Discounts are great, and they give them pretty often. It’s also pretty nice that they don’t expire for a while so you can use it up till a few months. I also noticed I can use it on sale peptides as well which is always great.

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