Description
AOD 9604 SPECIFICATIONS
AKA: AOD-9604
Molecular Formula: C78H123N23O23S2
Molecular Weight: 1815.1 g/mol
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
PubChem: CID 16131447
CAS Number: 386264-39-7
Reconstitution: Required
What is AOD 9604 peptide?
AOD 9604 is a modified peptide initially developed for the treatment of obesity. It modifies the peptide fragment 176-191 of human growth hormone (HGH). Interestingly, the mode of action of AOD 9604 is restricted to promoting lipolysis in the body, making it a popular choice for treating obesity. The peptide does not affect levels of insulin or IGF1 in the body. Therefore, using AOD 9604 does not trigger a clinical risk of developing diabetes or intolerance towards glucose. Also, because it is structurally similar to HGH, it does not induce immunogenic reactions and is immunologically safe.
Research
AOD 9604 and Obesity
AOD 9604 has been brought into clinical trials with the objective of targeting obesity using a peptide similar to HGH. Phase IIb clinical trials conducted on 300 obese individuals in Australia have shown that the peptide has resulted in consistent weight loss over 12 weeks when administered once daily. The rate of weight reduction in patients undergoing treatment has been greatly compared to the placebo cohort, and weight loss has been steady over the entire study period. This observation indicated that the peptide is unlikely to generate resistance, and thus continued treatment would result in a pronounced effect.
Researchers have worked on mice models to explore the underlying mechanism of AOD 9604. An initial hypothesis has proposed that AOD 9604 binds and activates β-3-adrenergic receptors, which are present on the surface of white adipose tissues. Upon binding to the cognate receptors, the peptide triggers downstream signaling, which mobilizes the fat cells from storage mode to a usable state by enhancing the rate of metabolism. Interestingly, mice genetically mutated in β-3-adrenergic receptors also have undergone fat loss, possibly through apoptosis of the white adipose tissues.
AOD 9604 and Cardiac Disease
AOD 9604 improves cardiac health indirectly by mobilizing fat and reducing obesity. The peptide thus reduces the chances of cardiac disease caused by obesity. Interestingly, apart from its principal function of decreasing the fat burden in the body, there are other mechanisms by which the drug improves cardiac conditions. These pathways are independent of β-3-adrenergic receptors and improve general metabolism, leading to improved cardiac health. Drugs are often known to induce various independent positive effects on the body. Some drugs such as acipimox and pioglitazone are known to improve metabolism without directly influencing fat reduction.
Joint Pain and Function
Improvement of cartilage growth has always been a persistent clinical challenge. Studies involving AOD9-604 have demonstrated that it helps to address this issue. Research have shown that introducing the peptide directly into arthritic joints in rats improves pain management, decreases movement disability, and enhances general quality of life. AOD 9604 can promote the growth of cartilage tissue in the arthritic joints, but the effect is pronounced in conjunction with other existing therapies. Clinical examination and microscopic cartilage structure analysis in the affected joints have shown positive results upon the AOD 9604 treatment of osteoarthritis. This highlights that application of this peptide can be beneficial in both the prevention and treatment of the above condition.
The peptide shows consistently minimal adverse effects and high bioavailability in the subcutaneous region of mice. However, the dosage administered to mice (per kg) cannot be scaled up for human administration.
All orders ship same day if placed by 2pm PST. Synthesized and lyophilized in the USA.This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.
Ignatiy Leyton –
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Milo Ramos –
Will order from here again. 5mg is the perfect amount so it doesnt end up sitting in your fridge going bad.
Aurora Clark –
Highly efficient peptide. Works really well
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The product is very effective, as described
Alexis Paytas –
I received a broken vial but it was a replacement sent no questions 🙂
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Fantastic Company. I have tried many other peptide companies and was disappointed. However, the quality here is top class. Whatever it says on the vial is in the vial.
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Professional customer service! They have refunded me my extra payment for next day delivery, because of a small misunderstanding
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Fast delivery and simple purchase. I haven’t gotten around to evaluating the quality of the goods yet.
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Nathanael R. Odom –
Customer service is as great as they said. I ran into a problem this week with the company(shocker). They sent me only three of my products instead of the five that I ordered. That’s a problem. I got ahold of one of their representatives and not going to lie I was really frustrated. The guy on the other end understood why and explained this is not a common occurrence at all. Nevertheless, they made sure to take care of it right away and refunded me for the missing products as well as give me a discount for the next purchase. I got my missing products within a few days. The whole process was a headache but they made up for it. I’m going to give them a try again and hopefully no more mishaps.
Alex Morales –
Been purchasing products from Biotech since August! hasn’t seemed to fail me yet
Joanna Marszalek –
Taylor is awesome, always helpful, and knows their stuff!! The product was out of stock and they were able to recommend a peptide that’s a substitute for the one I needed.
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Had a small issue with getting the products in time due to traveling all the way to India. I am happy to report that the peptides were no ruined in the process. Packaged perfectly
Leo Murphy –
Always amazed with the quality. Purity checks out everytime. Peptides are as true as they can be.
Harry Gagnon –
Have encountered a few times where peptides were broken but didn’t say anything as it was just one vial out of the bunch so it didn’t effect me too much. This morning when I opened my package almost all the peptide were shattered. Must have been a rough delivery process. Had to contact them but was not worried as i’ve seen some remarks about this happening to others. They didn’t even ask me for proof, Taylor just asked for the order number and confirmed the address.
Emily Roy –
Just put in my order with them again. I have been shopping with them for the past year. I have not had one bad experience with them. Really good company!
Christopher Adams –
They are a desent site to get peptides. Usually in stock of everything you need.
Susan Stivalo –
Taylor is great at what they do. In my bundle I put in the wrong peptide. Sent a quick email to Taylor and they were able to make the corrections happen.
Omar Sanchez –
Got 3 free bac waters instead of the 2 that were promised! Nice surprise
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Products were great and showed up in perfect condition.
Guerra Harold –
They are always in stock of the peptides I need. Have seen them be out of stock just a few times however their restock time is fast.
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I place orders constantly for our lab. Biotech is truly a reliable and great peptide supplier. We have been working with them for about 8 months now, since the end of 2021. Maybe its becuase we are loacted in Southern California as well but peptides have come in perfect condition and we have not experinced any significant delays thus far.
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Prices are the best i found for the quality.
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storage life is great, just follow the directions and you should be good to go
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Company is great, Peptides are even better.
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