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Differences in CJC-1295 vs Sermorelin for GHRH Delivery
The Structure of CJC-1295
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.954 g/mol
The Structure of Sermorelin
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.933 g/mol
Clearance and Structure
GRF (1-29) indicates the growth hormone-releasing factor (1-29), and is another name for Sermorelin. The modified form of GRF (1-29), which is sometimes speculated to be known as Mod GRF (1-29) or tetrasubstituted GRF (1-29), is another name for CJC-1295. The potency of the first 29 amino acids of GHRH is speculated to be the same as the potency of the full 44 amino acids of GHRH. Still, the natural metabolic clearance processes may clear very rapidly. To decrease the clearance rate and boost the half-life, Sermorelin can be modified so that CJC-1295 can be made more resistant to enzymatic cleavage. Research studies indicate that Sermorelin’s half-life is somewhere around five minutes, while the half-life of CJC-1295 appears to be 30 minutes.
DAC or no DAC?
The modification in CJC-1295 is often be done by adding a lysine residue and DAC, i.e., a chemical structure, to the carboxy-terminal end. DAC stands for drug affinity complex. The role of DAC is to help bind the molecules that it is attached to with the blood protein albumin. This action may help them extend the half-life of these compounds and extend their duration of action. With DAC, the time of total clearance of CJC-1295 might roughly increase from 1 hour to more than 96 hours.
Plasma Growth Hormone: CJC-1295 vs Sermorelin
The levels of Growth Hormone in the blood are suggested to be raised under the influence of both Sermorelin and CJC-1295, by the stimulation of the growth hormone-releasing hormone receptor in the anterior pituitary gland. Since both Sermorelin and CJC-1295 might operate at the level of the receptor of GHRH, they may preserve the normal pulsatile function of Growth Hormone secretion. However, Sermorelin appears to provides the more natural ebb and flow of Growth Hormone as it appears to be cleared much faster as compared to CJC-1295. The best way to explain the two peptides and their effects on the Growth Hormone curve is that both might raise the Growth Hormone levels and also both raise the preserving peaks and troughs, while the overall amount of time spent at the higher Growth Hormone levels might be extended by CJC-1295. In other words, it might be that the sharp peaks are turned into plateaus to some extent by the CJC-1295. With this, the effects of Growth Hormone may potentially be boosted substantially, and the physiology may also be altered to some degree. Still, one of the main reasons to prefer Sermorelin over the peptide CJC-1295 is that Sermorelin might provide the most speculated natural ebb and flow pattern.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.