Differences in CJC-1295 vs Sermorelin for GHRH Delivery

by | Jun 3, 2021 | Research

CJC-1295 vs Sermorelin – both Sermorelin and peptide CJC-1295 are the derivatives of growth hormone-releasing hormone (GHRH) and are often compared to one anothers properties and functions. In addition to the number of similar actions they share, both CJC-1295 and sermorelin also have differences. For the desired application, the choice of the best peptide depends more on the differences between them rather than the similarities that they share.

The Structure of CJC-1295 vs Sermorelin

Sermorelin is also known by GHRH 1-29, which means that the first 29 amino acids from a large growth hormone-releasing hormone are sermorelin. The structure of CJC-1295 also consists of the first 29 amino acids of GHRH, but the difference is that there is a modification in some of the amino acids.

The Structure of CJC-1295

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.954 g/mol

The Structure of Sermorelin

Sequence: Tyr-Ala-Asp-Ala-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Met-Ser-Arg

Molecular Formula: C149H246N44O42S

Molecular Weight: 3357.933 g/mol

GRF (1-29) means the growth hormone-releasing factor (1-29) is another name for Sermorelin. The modified form of GRF (1-29), which is sometimes known as Mod GRF (1-29) or tetrasubstituted GRF (1-29), is another name for CJC-1295. The potency of the first 29 amino acids of GHRH is the same as the potency of the full 44 amino acids of GHRH. Still, the natural metabolic clearance processes of the body clear it very rapidly. To decrease the clearance rate and boost the half-life, sermorelin was modified so that CJC-1295 can be made more resistant to enzymatic cleavage. Research studies indicate that sermorelin’s half-life is somewhere around five minutes, while the half-life of CJC-1295 is 30 minutes.

The Argument for CJC-1295 DAC

The modification in CJC-1295 is often done by adding a lysine residue and DAC, i.e., a chemical structure, to the carboxy-terminal end. DAC means drug affinity complex. The role of DAC is mainly to help bind the molecules that it is attached to with the blood protein albumin. This action helps them extend the half-life of these compounds and extend their duration of action. With DAC, the time of total clearance of CJC-1295 can roughly increase from 1 hour to more than 96 hours.

Although different scientists of this field are giving different opinions on whether the name CJC-1295 is used only for mod GRF (1-29) with DAC added or whether the “DAC” component must be specified since mod GRF(1-29) and CJC-1295 can be used interchangeably. The CJC-1295 is considered to be inclusive of DAC by the original developer. In other words, it can be said that when someone says “CJC-1295,” they simply mean mod GRF (1-29) with DAC added to it. Many people specify CJC-1295 with DAC simply to make it clear. In this article, the CJC-1295 mentioned refers to the modified version of mod GRF in which DAC is added.

Plasma Growth Hormone: CJC-1295 vs Sermorelin

The levels of Growth Hormone in the blood are raised by using both the sermorelin and CJC-1295, by the stimulation of the growth hormone-releasing hormone receptor in the anterior pituitary gland. Since both Sermorelin and CJC-1295 operate at the level of the receptor of GHRH, they preserve the normal pulsatile function of Growth Hormone secretion. However, if we talk about one amongst the two, then it is sermorelin that provides the more natural ebb and flow of Growth Hormone because it gets cleared from the body much faster as compared to CJC-1295. The best way to explain the two peptides and their effects on the Growth Hormone curve is that both raise the Growth Hormone levels and also both raise the relative preserving peaks and troughs, while the overall amount of time spent at the higher Growth Hormone levels is extended by CJC-1295. In other words, we can say that the sharp peaks are turned into plateaus to some extent by the CJC-1295. With this, the effects of Growth Hormone are boosted substantially, and the physiology is also altered to some degree. Still, one of the main reasons to prefer Sermorelin over the peptide CJC-1295 is that Sermorelin provides the most natural ebb and flow pattern.

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