Differences of BPC-157 and TB-500 in Tissue Repair

by | Sep 26, 2021 | Research

Peptides are short stretches of amino acids and can be either sourced from naturally prevalent proteins or synthesized. The amino acid sequences are so chosen that they retain the biological function of their full-length protein counterparts and mimic their biological functions. They play diverse roles from hormones, catalysts, and stimulants. The role of peptides in the various biological processes – whether by initiating a reaction, speeding processes up, stopping the action of catalytic enzymes, or stimulating the release of hormones – varies and is highly dependent on their mechanisms of action.

In this article, we will be comparing BPC-157 vs. TB-500, two very popular peptides, in terms of their chemistry, mechanism of action, and physiological influence.

Chemistry of BPC-157 vs. TB-500

Both BPC-157 and TB-500 are synthetic in origin, implying that they are not found in nature and don’t have common sequence homology with natural peptides.
BPC-157 is a pentadecapeptide of BPC or Body Protection Compound. BPC has been identified and isolated from the gastric juice of humans. BPC-157 is a partial sequence of BPC and comprises a chain of 15 amino acids.
TB-500, on the contrary, is also a synthetic form of Thymosin Beta 4, which is a water-soluble and regenerative compound found abundant in tears, saliva, and cerebrospinal fluid. TB-500 is the isolated (17)LKKTETQ(23) segment of Thymosin Beta 4 and also happens to be the segment responsible for its effects.

Mechanism of Action

The two peptides are very similar in their mode of action. However, extensive research is guaranteed to explain the mode of action for both molecules in greater detail.
Research indicates that BPC-157 mediates upregulation of growth hormones, modulates Nitric Oxide synthesis, enhances blood vessel production, and modifies collagen production as well as bone proteins.
TB-500 principally associates with actin, promotes cellular migration and regeneration, and blocks inflammatory chemokines and cytokines.

Effects of BPC-157 vs TB-500

Both the molecules have proven their role in several animal studies and in-vivo experiments.


The role of BPC-157 is centered on its ability to increase angiogenesis or the production of blood vessels by modifying the expression of Vascular Endothelial Growth Factor 2 (VEGFR2). This increase in angiogenesis triggers a cascade of different effects from faster wound healing, improved tendon and bone repair, and tissue regeneration in research subjects.
Another notable effect of BPC-157 is its unique ability to enhance the tendon repair process and reduce the recovery time needed for damaged tendons to return to their original strength.
BPC-157 also shows a cytoprotective effect, especially in the gastric mucosa, apart from the liver, pancreas, heart, and brain neurons. It is currently being researched for its effect on treating Inflammatory Bowel Syndrome (IBS), anxiety, depression, Parkinson’s, and multiple sclerosis.


The effects of TB-500, on the other hand, are based on its ability to bind with actin and improve tissue regeneration, tissue formation, and wound healing. It also improves several cell migration, re-epithelialization, and angiogenesis that are crucial in tissue repair and wound healing.
The peptide also exhibits an anti-inflammatory effect by suppressing the release of chemokines and cytokines responsible for inflammation. It is currently being studied for its cardioprotective and neuroprotective potentials.
In-vitro and in-vivo tests in animal models also show the ability of TB-500 to inhibit premature apoptosis or cell death in the heart and the hippocampal region of the brain.

Conclusion of BPC-157 vs TB-500

Based on theoretical deductions and scientific facts, both the peptides are useful in wound healing and tissue formation. They showcase angiogenesis and cytoprotective influence, although they affect different factors in the process.
The difference is that BPC-157 influences tendon and bone repair while TB-500 doesn’t. This means it could potentially be more beneficial in injuries that damaged tendons, ligaments, and bones. It also has more neurological effects compared to the latter.
TB-500, on the other hand, has anti-inflammatory, cardioprotective, and neuroprotective roles that BPC-157 lacks.


Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.