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BPC-157 (5mg & 10mg)
$52.00 – $92.00
BPC-157 peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
| Quantity | 5 - 9 | 10 + |
|---|---|---|
| Discount | 5% | 10% |
| Price | $49.40 – $87.40 | $46.80 – $82.80 |
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Description
What is the BPC-157 peptide?
BPC-157, which stands for Body Protection Compound-157, is obtained from the parent protein known as body protection compound (BPC). BPC is a naturally occurring protein in the digestive tract[1]. Research suggests that it protects the gastrointestinal tract lining from damage, mediates healing, and encourages the growth of blood vessels. BPC 157 is a penta-decapeptide made up of 15 amino acids. It is derived from a stretch of the body protection compound (BPC) discovered and purified from human gastric juice. Animal studies have observed its potential efficacy in healing different wounds such as muscle, tendon, and torn ligaments. It may further protect organs and help to prevent gastric ulcers[2]. Sikiric et al noted that there was a strong protection, noted following intragastric or intraperitoneal administration of BPC 157. BPC-157 also has the potential to enhance the health of the digestive tract and prevent against irritable bowel syndrome (IBS), gastrointestinal cramps, and Crohn’s disease. The peptide also has analgesic properties, and by promoting the blood flow to the damaged tissues, it may help heal skin burns faster.
The synthetic peptide appears to have retained several of the healing properties of its parent molecule, such as:
– Blood vessel growth
– Wound healing
– Nitric oxide generation
– Immune system function
– The coagulation cascade
– Gene expression
– Hormone regulation (specifically in the gastrointestinal, nervous system)
Specifications
AKA: BPC 157
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.5355 g/mol
Sequence: L-Valine,glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-Lprolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-;glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L- alpha-aspartylL-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine
PubChem: CID 108101
Reconstitution: Required
BPC-157 Peptide Research and Clinical Studies
BPC-157 and Wound Healing
The GI tract’s mucosal barrier is considered to help protect the underlying tissues from the harmful actions of bile, gastric acid, and other compounds necessary for the digestion and absorption of nutrients from food. BPC-157 is believed to help preserve the structural integrity of the mucosal layer. The role appears to be partially mediated through the recruitment of fibroblasts. Fibroblasts are considered pivotal to healing wounds as they produce extracellular matrix proteins such as fibrin, collagen, elastin, and others. BPC-157 has been observed to promote the proliferation and faster migration of fibroblasts in a concentration-dependent manner.[3] In another trial it was hypothesized that BPC-157 may have led to an acceleration in wound closure compared to the control group via an improvement in the formation of granulation tissue, reepithelialization, dermal remodeling, and collagen deposition. There is a possibility that BPC-157 may have promoted the expression of vascular endothelial growth factor (VEGF) in the injured skin tissues[4]. Moreover, the researchers commented that BPC-157 may have shown a potential to enhance umbilical vein endothelial cell proliferation (HUVECs). Furthermore, there may have been a significant increase in the migration of HUVECs, as indicated by the comments from wound healing assays. Adding BPC-157 possibly resulted in an upregulation of VEGF-a expression and acceleration of vascular tube formation in vitro. It also appeared that BPC-157 might have regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and their downstream targets, including c-Fos, c-Jun, and Egr-1. These molecules are hypothesized to potentially play significant roles in cell growth, migration, and angiogenesis.[4]
BPC-157 and Vascular Growth and Collateralization
The peptide has the potential as an angiogenic, and studies suggest it may enhance endothelial cells’ growth and proliferation, which line the walls of blood vessels. Research in rats has observed that the peptide may substantially increase the collateral blood vessel growth rate in the setting of ischemia.[5] The above effect has been primarily observed in the GI tract, but research has noted similar observations in muscle, neurological, and cardiovascular tissues. Research using chicken embryos has posited that BPC-157 may also have the potential to promote vascular growth through activation of VEGFR2 pathway. VEGFR2 is a cell surface receptor active in nitric oxide signaling and is considered to help in cell growth, longevity, and proliferation. BPC-157 may promote vascular “running” in cultured cells. Vascular “running” is the growth and development of new blood vessels towards a site of injury or around the area of blood clot to reach out to distal tissues and thus protect cellular function.
BPC-157 and Tendon Healing
BPC-157 studies have observed positive potential in connective tissue healing such as ligament, bone, and tendon. Ligament and tendon injuries take a long time to heal due to the poor blood supply to these tissues. There is slower migration of fibroblasts and wound-healing cells to these sites of injury owing to the poor blood supply, and therefore the repair process is obstructed. The peptide has the potential to improve the collateralization and density of fibroblasts in the sites of injury in research involving rat tendons.[6] More specifically, the study also hypothesized that BPC-157 might significantly accelerate the outgrowth of tendon fibroblasts from tendon explants. This suggests that BPC-157 may potentially promote the growth of new cells in the injured tendon. Further, the survival of the cells to which BPC-157 was applied may be significantly increased when exposed to H(2)O(2) stress, indicating a potential protective action against oxidative stress. BPC-157 may also enhance the migration of tendon fibroblasts, as indicated by the transwell filter migration assay used in the study. This may imply that BPC-157 potentially promotes the movement of tendon fibroblasts, which may be important for tissue repair. Moreover, BPC-157 may accelerate the spreading of tendon fibroblasts on culture dishes, suggesting potentially increased cell adhesion and attachment.[6]
This experimental research has suggested BPC-157 to be a more positive impactor than EFG, bFGF, and VGF hormones. Immunostaining assays involving FITC conjugated phalloidin have observed BPC-157 to enhance F-actin formation in fibroblasts. F-actin is crucial for cell structure and function and promotes cell migration. Immunoblotting experiments have noted that BPC-157 appears to increase the phosphorylation of paxillin and FAK proteins which are crucial for cellular migration. More specifically, BPC-157 may induce F-actin formation in tendon fibroblasts, potentially indicating enhanced cytoskeletal organization and cell motility. Further analysis using Western blotting indicates that BPC-157 may activate the FAK (focal adhesion kinase) and paxillin proteins. The phosphorylation levels of FAK and paxillin may increase with BPC-157, while the total amounts of these proteins may remain unchanged. This potentially suggests that BPC 157 may activate the FAK-paxillin pathway, which may be involved in the promotion of tendon fibroblast migration and cell adhesion.[6]
BPC-157 and Antioxidant Potential
Studies in rat models have noted that BPC-157 appears to have antioxidant properties and may help to neutralize oxidative stress molecules like nitric oxide and malondialdehyde (MDA) and reactive oxygen species in the GI tract.[7] Research further hypothesized that modified Lactococcus lactis bacteria may increase the amount of the peptide in cell culture and can possibly deliver it to the GI tract.
Another study apparently aimed to evaluate early functional recovery and inflammation in tendon cells after the application of BPC-157[8]. The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers. The results suggest that BPC-157 may have improved functional recovery, as indicated by a potential increase in AFI values at all time points. This improvement was hypothesized to be attributed to its purported anti-inflammatory properties, including a potential decrease in myeloperoxidase (MPO) activity and histological inflammatory cell influx. Furthermore, BPC-157 potentially increased the formation of new blood vessels, as inferred by a possible increase in the vascular index. On the other hand, methylprednisolone also possibly decreased MPO activity and histological inflammatory cell influx, suggesting its potential anti-inflammatory action. However, methylprednisolone hypothetically decreased the formation of new blood vessels and may not have significantly affected early functional recovery.[8]
Another study examined the proposed action of a pentadecapeptide BPC-157 on inflammation and bone resorption in experimental periodontitis. Inflammation was assessed using the Evans blue plasma extravasation technique and histology. Evans blue extravasation hypothetically refers to the potential leakage of Evans blue dye from blood vessels into the surrounding tissues, which potentially indicates increased vascular permeability possibly associated with inflammation. The histological analysis appeared to provide visual evidence of inflammation. The results that the induction of periodontitis potentially caused a significant increase in Evans blue extravasation, histological signs of inflammation, and alveolar bone destruction. However, the administration of BPC 157 appeared to significantly reduce plasma extravasation, histological alterations potentially associated with inflammation, and alveolar bone resorption.[9]
BPC-157 and and the Central Nervous System
The potential of BPC-157 has been investigated in a murine model of traumatic brain injury (TBI), suggesting some positive outcomes. The peptide appeared to lead to a significant attenuation of TBI-induced damage and improved early outcomes based on the observed experiments. During the 24-hour post-injury period, there seemed to be minimal mortality. The severity of traumatic lesions, such as subarachnoid and intraventricular hemorrhage, brain laceration, and hemorrhagic laceration, appeared to be less pronounced in the BPC-157 group. Furthermore, there seemed to be a considerable improvement in brain edema. Hypothetically, if introduced prior to TBI, BPC-157 may have exhibited an improved conscious/unconscious/death ratio. BPC-157 potentially demonstrated a counteractive action against unconsciousness and lower mortality. Moreover, the immediate presentation of BPC-157 before injury may have also reduced the damage in murine models subjected to a force impulse.[10]
BPC-157 and Bees
Colony collapse disorder (CCD) is a syndrome that causes entire colonies of bees to decline rapidly and die entirely, possibly due to Nosema ceranae fungal infection in the GI tract of bees. Experimental use of BPC-157 along with bee food noted significant improvement of the bee GI tract and hive survival.In this research, the peptide was successful for oral use in natural field settings to reduce the effect of CCD on bees which is the natural pollinator of many crop plants.
Future Research
BPC-157 is being actively studied in a number of cell culture and animal models. The peptide not only has the potential to assist in wound healing and vascular growth but also to study the regulation of these processes, especially in angiogenesis which is extremely crucial in wound healing, cancer progression, and embryo development. BPC-157 studies have reported minimal adverse effects, medium oral, and excellent subcutaneous bioavailability in mice. The dosage in mice (per kg) does not scale up to humans.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Jelovac, N., Sikirić, P., Rucman, R., Petek, M., Perović, D., Konjevoda, P., Marović, A., Seiwerth, S., Grabarević, Z., Sumajstorcić, J., Dodig, G., & Perić, J. (1998). A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine. Biological psychiatry, 43(7), 511–519. https://doi.org/10.1016/s0006-3223(97)00277-1
- Sikirić, P., Mazul, B., Seiwerth, S., Grabarević, Z., Rucman, R., Petek, M., Jagić, V., Turković, B., Rotkvić, I., Mise, S., Zoricić, I., Jurina, L., Konjevoda, P., Hanzevacki, M., Gjurasin, M., Separović, J., Ljubanović, D., Artuković, B., Bratulić, M., Tisljar, M., … Sumajstorcić, J. (1997). Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Digestive diseases and sciences, 42(3), 661–671. https://doi.org/10.1023/a:1018880000644
- Tkalcević, V. I., Cuzić, S., Brajsa, K., Mildner, B., Bokulić, A., Situm, K., Perović, D., Glojnarić, I., & Parnham, M. J. (2007). Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. European journal of pharmacology, 570(1-3), 212–221. https://doi.org/10.1016/j.ejphar.2007.05.072
- Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug design, development and therapy, 9, 2485–2499. https://doi.org/10.2147/DDDT.S82030
- Hsieh, M. J., Liu, H. T., Wang, C. N., Huang, H. Y., Lin, Y., Ko, Y. S., Wang, J. S., Chang, V. H., & Pang, J. S. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of molecular medicine (Berlin, Germany), 95(3), 323–333. https://doi.org/10.1007/s00109-016-1488-y
- Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of applied physiology (Bethesda, Md. : 1985), 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010
- Škrlec, K., Ručman, R., Jarc, E., Sikirić, P., Švajger, U., Petan, T., Perišić Nanut, M., Štrukelj, B., & Berlec, A. (2018). Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities. Applied microbiology and biotechnology, 102(23), 10103–10117. https://doi.org/10.1007/s00253-018-9333-6
- Krivic, A., Majerovic, M., Jelic, I., Seiwerth, S., & Sikiric, P. (2008). Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone. Inflammation research : official journal of the European Histamine Research Society … [et al.], 57(5), 205–210. https://doi.org/10.1007/s00011-007-7056-8
- Keremi, B., Lohinai, Z., Komora, P., Duhaj, S., Borsi, K., Jobbagy-Ovari, G., Kallo, K., Szekely, A. D., Fazekas, A., Dobo-Nagy, C., Sikiric, P., & Varga, G. (2009). Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60 Suppl 7, 115–122.
- Tudor, M., Jandric, I., Marovic, A., Gjurasin, M., Perovic, D., Radic, B., Blagaic, A. B., Kolenc, D., Brcic, L., Zarkovic, K., Seiwerth, S., & Sikiric, P. (2010). Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regulatory peptides, 160(1-3), 26–32. https://doi.org/10.1016/j.regpep.2009.11.012
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
| Brand | Biotech Peptides |
|---|---|
| Please select a size | 10mg, 5mg |
67 reviews for BPC-157 (5mg & 10mg)
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Benji Hyrum –
Excellent product and excellent service
Raven Martinez –
Checkout is a breeze, really helpful website structure. They even had my info saved for me so that I would not have to input it every time I made a purchase. My only comment is I wish I could see my past purchases as well.
Silas Allen –
I am looking forward to receiving my new products and testing them out. Very good company
Jade Hughes –
Everything from A to Z is just great! From service to the products and the delivery, everything is just on point
River Brooks –
Peptides here are good. I like the fact that they send out their products relatively fast after you place an order. Got mine I’d say within a day or two. Showed up in a standard box and nothing looked mishandled. My only comment is I did expect some way to keep the peptides cool inside to maintain the perfect temperature but they seemed to have held up well.
Avery Chavez –
This company has become my no 1 peptide supplier. I initially started with peptides warehouse but the after they developed a bad rap on the forums I started looking around and found biotech.
Artemis Ruiz –
Ordering from them is a breeze
Sebastian Cook –
Works exactly as advertised
Sunil Ghuptkur –
really like this, can’t go wrong if you know what you’re doing
Robert Lesner –
This product has a lot of potential from the research I’ve done. Ive looked into it quite a bit and consistent research with this product is crucial.
Chee Nguyen –
Happy that a friend recommended this company. I was getting a good deal on products from a different place but biotech has both deals and fast shipping that can’t be competed with!
Elliot Duffy –
I couldn’t ask for a smoother transaction. I usually shop at loti but shipping times and product consistency is way better here. Paying with a credit card is also very convenient.
Piper Boyle –
I was having trouble figuring out how much bacteriostatic water to use to dilute the product. So I called customer service and was very pleased with their patience and excitement to help
Orion Quinn –
Perfect for running experiments. I work as an assistant to a professor here in the midwest and this company has made our research a breeze.
Bailey Sparks –
mixes easily with bacteriostatic water
Daniella Tiiu –
I am 110% sure I will never switch suppliers again
Hughes Evelyn –
first timer, good doing busniess with ya!
Charlie Haskett –
I love that you guys have a blog. It helps a lot with discovering the potential of peptides I didn’t know anything about. Some other companies don’t have them, so I have to do additional research if I’m interested in something, which is time consuming. You have it all in one place. Kudos
Corey Scott –
Love their site. awsome selection of peptides, I appreciate their sales and frequent discounts they send out!
Doug Duensing –
I had an issue with them sending me the wrong product once, but they promptly sent the right one and let me keep the one they sent by mistake. Amazing folks
Marissa Benson –
Got everything I needed, thankfully nothing was out of stock either. when I checked the next day whatever I got was so looks like they sell out quick
Hamala Makala –
Awsome peptide company, best prices I’ve come by.
Collin Roads –
I have always had a good experience with them. They have peptides of the highest quality and are legit.Also have an amazing policy and honor it if anything was to go wrong like a lost peptide, broken peptides, etc.
Andres Duran –
Found them while researching on bpc-157 5mg. Took the plunge and happy with my choice! They got some solid prodcuts. Can’t wait to experiment with other products in the future.
Emily Roy –
Only site I found with this product in stock! Glad they have it, price is not bad either. Also have a huge selection of peptides what I haven’t seen too much of. Definitely going to look into more of the topical options as well.
Reece Lam –
They have exceptional peptides! Fast shipping as well.
Theodore Mitchell –
All their employees are trained well. They know the products off the bat and with me have no made mistakes when I need a fix on location or need to add a peptide in my order.
Ryan P. –
I think their prices are decent, not breaking the bank. Quality is pretty good too for the price.
Jamal Thomas –
As a company doing business with them is great. We are able to order all the necessary peptides within minutes and they are hardly out of stock with whatever we need. They also have offered a discount code for us to input with every purchase.
steven sigler –
peptides are exceptional, cool packaging.
katherine Freeman –
I always buy in bulk and have not had an issue with products not coming in on time or being put of stock. I mostly converse with Taylor as well for all my orders.
Marvin Santiago –
The website is easy to use and I especially like their blog area and how up to date it is.
Daniel rossi –
Had no problems with customs when I order with them. In the past with other companies my peptides have been stuck for weeks to the point the peptides were unusable so I’m very happy with this change.
Dillon Drummen –
The company has showed it stands with what they quote. I had an issue a few months back regarding my peptides. They essentially were missing. I placed to order, got a conformation e-mail and a day later found out they were having a small issue with their shipping system so it would be delayed by a day or two. That’s fine, technical things come up. However, once they did fix the issue and I received my shipping confirmation I still did not have any peptides. Mind you it’s been days since I got the shipping e-mail. I once again contacted them and Taylor was the one that handled it. At this point it seems the package may have been lost from the carriers end and they offered me two options. 1. A full refund with a discount code for the next purchase or 2. Reshipment of the products but with next day shipping. At this point I wanted my money back so I got my refund. I have given them another shot though and have ordered products a few times and have never had that happen again.
Summer Melgar –
I cannot begin to explain how excited I am to receive my first order. Will be back with an update
Cam Botello –
There is no need to worry about anything throughout the whole procedure, from purchasing peptides to receiving them.
Zac Gastelo –
The things they sell are of the highest quality! My only worry is that they seem to run out of things really quickly.
Ross Kramer –
You can trust this business. Biotech’s peptides have shown to be of good quality during the last eight months that I’ve been utilizing them, rather than hindering my study.
Blake Torija –
For a time now, I’ve been working with them. Decided to test them out after receiving a promotional email. They have a lot of nice products, and they do a wonderful job of making frequent offers or discounts available.
Travis lee –
Worth buying as they’re lower costing than some other places. They also allow coupon codes to be used with sale items which many places don’t even offer so you’re saving even more there as well.
Dirk Bakker –
Got some free bac water and they added a second one for being a loyal customer for a year now.
Derek McClave –
Peptides are pure and show to be effective on my research.
Iman Mossanen –
Sincer using Biotech my research results have been outstanding. Really good stuff you put out there
Gulen Aksoley –
This company makes my work so much easier. Products are always sent correctly and never had a hitch with them!
Amir Kashfi –
Only had a few small mishaps since working with them and they resolved them quickly. I’d say they have good customer service compared to a few other places I have done business with in the past. Most places you don’t hear from or just straight up disappear on you but not the case here.
Shirin Dina –
Restock was fast!!
Jake Libenson –
Everyone in the company I work for is very pleased with the service BP provides everytime. Really good work on their part
Jordan Grinsfelder –
Amazing products and even more amazing staff. They have a good return time and have been able to help me out with small issues that have come up with payments or shipping.
Adam Meleo –
The peptide here are fantastic. Same basic procedure for storage but I think they last better than most other places peptides.
Jared Wexler –
Customer service is fast and they know what they’re doing. Haven’t been contacting by anyone who was clueless about peptides or anything in that involved peptides.
Sid Toriggino –
10/10 for me!
Aditya Mantha –
My company has been doing business with them for a while now and they have never let us down in any way. We will surely continue to work with them for as long as possible
Ari Carrilo –
Good storage life! No issues with any and they last when stored as directed.
Justice Achonu –
Great place to get REAL and PURE peptides from! Also they keep growing and expanding their peptide supply as well. I used to have to shop around other places as well. Now I can shop for it all in one place.
Jack Thai –
This is an amazing peptide in blends but also by itself
Jacob Arnold –
Can’t rave enough about this product
JT Tang –
My orders and credit card information were always handled with the utmost care and they proved reliability every single time I bought from them
Patrick Wiltz –
Never buying peptides from anywhere else ever again. This company is so sufficient for whatever you may need
Jean Tang –
Research flourished since I started experimenting with peptides from Biotech. Results are amazing
Bruck Gezahegn –
Legitimacy is such an issue with these online companies all the time, but Biotech is 100%. This is my go-to, no stress, no questions asked, no worries
Josh Kohanchi –
The amazing way they handle their issues says a lot about how organized and reliable they are.
Anthony Tran –
Very good product
Doug Cruz –
Research results on this are astonishing and the progress is unbelieveable!
Ben Rotberg –
Noticed a difference in my research once I started using their peptides, the quality of peptides really does change results.
Harrison Neider –
Have been working with peptides for a long time and this place has one of the purest peptides I have worked with.
Gert August –
Pretty easy to get in contact with them. Didn’t take long to get a hold of someone through e-mail. Few back and forth messages between me and Danny and we got the issue of my missing peptide order handled.
Paul Garcxia –
Fast Service Quality product! Def Recommend!