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BPC-157 (5mg & 10mg)
$52.00 – $92.00
BPC-157 peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
| Quantity | 5 - 9 | 10 + |
|---|---|---|
| Discount | 5% | 10% |
| Price | $49.40 – $87.40 | $46.80 – $82.80 |
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Description
What is the BPC-157 peptide?
BPC-157, which stands for Body Protection Compound-157, is obtained from the parent protein known as body protection compound (BPC). BPC is a naturally occurring protein in human digestive tract[1]. Research suggests that it protects the gastrointestinal tract lining from damage, mediates healing, and encourages the growth of blood vessels. BPC 157 is a penta-decapeptide made up of 15 amino acids. It is derived from a stretch of the body protection compound (BPC) discovered and purified from human gastric juice. Animal studies have observed its potential efficacy in healing different wounds such as muscle, tendon, and torn ligaments. It may further protect organs and help to prevent gastric ulcers[2]. Sikiric et al noted that there was a strong protection, noted following intragastric or intraperitoneal administration of BPC 157. BPC-157 also has the potential to enhance the health of the digestive tract and prevent against irritable bowel syndrome (IBS), gastrointestinal cramps, and Crohnโs disease. The peptide also has analgesic properties, and by promoting the blood flow to the damaged tissues, it may help heal skin burns faster.
The synthetic peptide appears to have retained several of the healing properties of its parent molecule, such as:
– Blood vessel growth
– Wound healing
– Nitric oxide generation
– Immune system function
– The coagulation cascade
– Gene expression
– Hormone regulation (specifically in the gastrointestinal, nervous system)
Specifications
AKA: BPC 157
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.5355 g/mol
Sequence: L-Valine,glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-Lprolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-;glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L- alpha-aspartylL-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine
PubChem: CID 108101
Reconstitution: Required
BPC-157 Research
BPC-157 and Wound Healing
The mucosal barrier in the GI tract helps to protect the underlying tissues from the harmful actions of bile, gastric acid, and other compounds necessary for digestion and absorption of nutrients from food. BPC-157 is believed to help preserve the structural integrity of the mucosal layer. The role is partially mediated through the recruitment of fibroblasts. Fibroblasts are pivotal to healing wounds as they produce extracellular matrix proteins such as fibrin, collagen, elastin, and others. BPC-157 has been observed to promote proliferation and faster migration of fibroblasts in dose-dependent manner, both in culture and in vivo[3].
BPC-157 and Vascular Growth and Collateralization
The peptide has the potential to be a powerful angiogenic and studies suggest it may enhance endothelial cells’ growth and proliferation, which line the walls of blood vessels. Research in rats has observed that the peptide may substantially increase the collateral blood vessel growth rate in the setting of ischemia[4]. The above effect has been majorly observed in the GI tract, but research has noted similar observations in muscle, neurological, and cardiovascular tissues. Thus, the findings highlight the potential of BPC-157 to be used for the treatment of stroke and heart attack and a probative molecule for understanding the healing process post-ischemic injury. Research using chicken embryos has posited that BPC-157 may also have the potential to promote vascular growth through activation of VEGFR2 pathway. VEGFR2 is a cell surface receptor active in the nitric oxide signaling and helps in cell growth, longevity, and proliferation. BPC-157 treatment may promote vascular โrunningโ in cultured cells. Vascular โrunningโ is the growth and development of new blood vessels towards a site of injury or around the area of blood clot to reach out to distal tissues and thus protect cellular function. This function of BPC-157 has the potential to be used to replace unwanted surgical interventions such as coronary artery bypassing, stenting, and more which a simple and effective oral medication for the slow-progressing vascular occlusions like in atherosclerotic cardiac conditions.
BPC-157 and Tendon Healing
BPC-157 studies have so far observed positive effects in connective tissue healing such as ligament, bone, and tendon. Ligament and tendon injuries take a long time to heal due to the poor blood supply to these tissues. There is slower migration of fibroblasts and wound-healing cells to these sites of injury owing to poor blood supply, and therefore the repair process is obstructed. The peptide has the potential to improve collateralization and density of fibroblasts in the sites of injury in research involving rat tendons[5]. Experimental research has found BPC-157 to be more beneficial than treatment using EFG, bFGF, and VGF hormones. Immunostaining assays involving FITC conjugated phalloidin have observed BPC-157 enhance F-actin formation in fibroblasts. F-actin is crucial for cell structure and function and promotes cell migration. Immunoblotting experiments have noted that BPC-157 appears to increase phosphorylation of paxillin and FAK proteins which are crucial for cellular migration.
BPC-157 and antioxidant properties
Studies in rat models have noted the BPC-157 appears to have antioxidant properties and may help to neutralize oxidative stress molecules like nitric oxide and malondialdehyde (MDA) and reactive oxygen species in the GI tract[6]. Research further hypothosizes that modified Lactococcus lactis bacteria may increase the amount of the peptide in cell culture and can possibly deliver it to the GI tract.
BPC-157 and Drug Side Effects
The clinical use of a pharmaceutical molecule is restricted by its potential side effects. Ibuprofen and other NSAIDs, for instance, cannot be consumed over a long span as they increase the risk of gastric bleeding and cardiac arrest. BPC-157 has been suggested as a potential treatment to overcome the adverse effects of NSAIDs, medications used in psychiatric conditions, and a number of cardiac medications.
The peptide has the potential to work against the side effects of various drugs on not only the GI tract but on brain, heart and other tissues as well. BPC-157 research has observed the peptide’s protective potential against the prolongation of QTc in the hearts in rats. Prolonged QTc can lead to fatal arrhythmias. QTc prolongation is a side effect of drugs used to treat diabetes, schizophrenia, and other psychiatric conditions. Similarly, BPC-157 may also overcome catalepsy and somatosensory disturbance. This helps treat difficult psychiatric conditions as patients tend to discontinue the treatment due to severe side effects.
BPC-157 and Bees
Colony collapse disorder (CCD) is a syndrome that causes entire colonies of bees to decline rapidly and die entirely, possibly due to Nosema ceranae fungal infection in the GI tract of bees. Experimental use of BPC-157 along with bee food noted significant improvement of the bee GI tract and hive survival.In this research, the peptide was successful for oral use in natural field settings to reduce the effect of CCD on bees which is the natural pollinator of many crop plants.
Future Research
BPC-157 is being actively studied in a number of cell culture and animal models. The peptide not only has the potential to assist in wound healing and vascular growth but also to study the regulation of these processes, especially in angiogenesis which is extremely crucial in wound healing, cancer progression, and embryo development. BPC-157 studies have reported minimal adverse effects, medium oral, and excellent subcutaneous bioavailability in mice. The dosage in mice (per kg) does not scale up to humans.
References
- Jelovac, N., Sikiriฤ, P., Rucman, R., Petek, M., Peroviฤ, D., Konjevoda, P., Maroviฤ, A., Seiwerth, S., Grabareviฤ, Z., Sumajstorciฤ, J., Dodig, G., & Periฤ, J. (1998). A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine. Biological psychiatry, 43(7), 511โ519. https://doi.org/10.1016/s0006-3223(97)00277-1
- Sikiriฤ, P., Mazul, B., Seiwerth, S., Grabareviฤ, Z., Rucman, R., Petek, M., Jagiฤ, V., Turkoviฤ, B., Rotkviฤ, I., Mise, S., Zoriciฤ, I., Jurina, L., Konjevoda, P., Hanzevacki, M., Gjurasin, M., Separoviฤ, J., Ljubanoviฤ, D., Artukoviฤ, B., Bratuliฤ, M., Tisljar, M., โฆ Sumajstorciฤ, J. (1997). Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Digestive diseases and sciences, 42(3), 661โ671. https://doi.org/10.1023/a:1018880000644
- Tkalceviฤ, V. I., Cuziฤ, S., Brajsa, K., Mildner, B., Bokuliฤ, A., Situm, K., Peroviฤ, D., Glojnariฤ, I., & Parnham, M. J. (2007). Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. European journal of pharmacology, 570(1-3), 212โ221. https://doi.org/10.1016/j.ejphar.2007.05.072
- Hsieh, M. J., Liu, H. T., Wang, C. N., Huang, H. Y., Lin, Y., Ko, Y. S., Wang, J. S., Chang, V. H., & Pang, J. S. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of molecular medicine (Berlin, Germany), 95(3), 323โ333. https://doi.org/10.1007/s00109-016-1488-y
- Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of applied physiology (Bethesda, Md. : 1985), 110(3), 774โ780. https://doi.org/10.1152/japplphysiol.00945.2010
- ล krlec, K., Ruฤman, R., Jarc, E., Sikiriฤ, P., ล vajger, U., Petan, T., Periลกiฤ Nanut, M., ล trukelj, B., & Berlec, A. (2018). Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities. Applied microbiology and biotechnology, 102(23), 10103โ10117. https://doi.org/10.1007/s00253-018-9333-6
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only.ย Human or animal use and/or consumption is strictly prohibited by law.ย Only qualified and licensed professionals should handle these products.ย Any information found on Biotech Peptides is strictly for educational purposes only.ย Refer to our terms and conditions for more details.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
| Brand | Biotech Peptides |
|---|---|
| Size | 10mg, 5mg |
Benji Hyrum –
Excellent product and excellent service
Raven Martinez –
Checkout is a breeze, really helpful website structure. They even had my info saved for me so that I would not have to input it every time I made a purchase. My only comment is I wish I could see my past purchases as well.
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I am looking forward to receiving my new products and testing them out. Very good company
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Everything from A to Z is just great! From service to the products and the delivery, everything is just on point
River Brooks –
Peptides here are good. I like the fact that they send out their products relatively fast after you place an order. Got mine I’d say within a day or two. Showed up in a standard box and nothing looked mishandled. My only comment is I did expect some way to keep the peptides cool inside to maintain the perfect temperature but they seemed to have held up well.
Avery Chavez –
This company has become my no 1 peptide supplier. I initially started with peptides warehouse but the after they developed a bad rap on the forums I started looking around and found biotech.
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Ordering from them is a breeze
Sebastian Cook –
Works exactly as advertised
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Robert Lesner –
This product has a lot of potential from the research I’ve done. Ive looked into it quite a bit and consistent research with this product is crucial.
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I couldn’t ask for a smoother transaction. I usually shop at loti but shipping times and product consistency is way better here. Paying with a credit card is also very convenient.
Piper Boyle –
I was having trouble figuring out how much bacteriostatic water to use to dilute the product. So I called customer service and was very pleased with their patience and excitement to help
Orion Quinn –
Perfect for running experiments. I work as an assistant to a professor here in the midwest and this company has made our research a breeze.
Bailey Sparks –
mixes easily with bacteriostatic water
Daniella Tiiu –
I am 110% sure I will never switch suppliers again
Hughes Evelyn –
first timer, good doing busniess with ya!
Charlie Haskett –
I love that you guys have a blog. It helps a lot with discovering the potential of peptides I didn’t know anything about. Some other companies don’t have them, so I have to do additional research if I’m interested in something, which is time consuming. You have it all in one place. Kudos
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Love their site. awsome selection of peptides, I appreciate their sales and frequent discounts they send out!
Doug Duensing –
I had an issue with them sending me the wrong product once, but they promptly sent the right one and let me keep the one they sent by mistake. Amazing folks
Marissa Benson –
Got everything I needed, thankfully nothing was out of stock either. when I checked the next day whatever I got was so looks like they sell out quick
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Awsome peptide company, best prices I’ve come by.
Collin Roads –
I have always had a good experience with them. They have peptides of the highest quality and are legit.Also have an amazing policy and honor it if anything was to go wrong like a lost peptide, broken peptides, etc.
Andres Duran –
Found them while researching on bpc-157 5mg. Took the plunge and happy with my choice! They got some solid prodcuts. Can’t wait to experiment with other products in the future.
Emily Roy –
Only site I found with this product in stock! Glad they have it, price is not bad either. Also have a huge selection of peptides what I haven’t seen too much of. Definitely going to look into more of the topical options as well.
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They have exceptional peptides! Fast shipping as well.
Theodore Mitchell –
All their employees are trained well. They know the products off the bat and with me have no made mistakes when I need a fix on location or need to add a peptide in my order.
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Jamal Thomas –
As a company doing business with them is great. We are able to order all the necessary peptides within minutes and they are hardly out of stock with whatever we need. They also have offered a discount code for us to input with every purchase.
steven sigler –
peptides are exceptional, cool packaging.
katherine Freeman –
I always buy in bulk and have not had an issue with products not coming in on time or being put of stock. I mostly converse with Taylor as well for all my orders.
Marvin Santiago –
The website is easy to use and I especially like their blog area and how up to date it is.
Daniel rossi –
Had no problems with customs when I order with them. In the past with other companies my peptides have been stuck for weeks to the point the peptides were unusable so I’m very happy with this change.
Dillon Drummen –
The company has showed it stands with what they quote. I had an issue a few months back regarding my peptides. They essentially were missing. I placed to order, got a conformation e-mail and a day later found out they were having a small issue with their shipping system so it would be delayed by a day or two. That’s fine, technical things come up. However, once they did fix the issue and I received my shipping confirmation I still did not have any peptides. Mind you it’s been days since I got the shipping e-mail. I once again contacted them and Taylor was the one that handled it. At this point it seems the package may have been lost from the carriers end and they offered me two options. 1. A full refund with a discount code for the next purchase or 2. Reshipment of the products but with next day shipping. At this point I wanted my money back so I got my refund. I have given them another shot though and have ordered products a few times and have never had that happen again.
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I cannot begin to explain how excited I am to receive my first order. Will be back with an update
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There is no need to worry about anything throughout the whole procedure, from purchasing peptides to receiving them.
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The things they sell are of the highest quality! My only worry is that they seem to run out of things really quickly.
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You can trust this business. Biotech’s peptides have shown to be of good quality during the last eight months that I’ve been utilizing them, rather than hindering my study.
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Got some free bac water and they added a second one for being a loyal customer for a year now.
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Peptides are pure and show to be effective on my research.
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Sincer using Biotech my research results have been outstanding. Really good stuff you put out there
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This company makes my work so much easier. Products are always sent correctly and never had a hitch with them!
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Only had a few small mishaps since working with them and they resolved them quickly. I’d say they have good customer service compared to a few other places I have done business with in the past. Most places you don’t hear from or just straight up disappear on you but not the case here.
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Restock was fast!!
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Everyone in the company I work for is very pleased with the service BP provides everytime. Really good work on their part
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Amazing products and even more amazing staff. They have a good return time and have been able to help me out with small issues that have come up with payments or shipping.
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The peptide here are fantastic. Same basic procedure for storage but I think they last better than most other places peptides.
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Customer service is fast and they know what they’re doing. Haven’t been contacting by anyone who was clueless about peptides or anything in that involved peptides.
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Good storage life! No issues with any and they last when stored as directed.
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Great place to get REAL and PURE peptides from! Also they keep growing and expanding their peptide supply as well. I used to have to shop around other places as well. Now I can shop for it all in one place.
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This is an amazing peptide in blends but also by itself
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Research results on this are astonishing and the progress is unbelieveable!
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Noticed a difference in my research once I started using their peptides, the quality of peptides really does change results.