BPC-157 & TB-500 Blend and its Potential for Wound Repair

by | May 23, 2022 | Research

What Is BPC-157?

BPC-157 is a peptide sequence of about 15 amino acids derived from human gastric juice. The peptide has numerous potential benefits. It may aid in issues regarding the following

• Nervous System
• Bones
• Tendons
• Ligaments


How does BPC-157 Work?

The mechanism by which pentadecapeptide BPC-157 accelerates healing is not clearly understood. Research suggests that the healing action of BPC-157 can be a combination of a variety of these factors. These include upregulating growth factors, proangiogenic effects, and nitric oxide (NO) synthesis. BPC-157 may also control the functions of collagen fragments. Research also suggests that BPC-157 has a connection with bone morphogenic proteins.


Properties of the Peptide BPC-157

The peptide BPC-157 is a small pentadecapeptide sequence from the much larger human gastric juice protein, BPC. Since it has a highly stable structure, the peptide is very resistant to the degenerating effects of hydrolysis and enzyme metabolism. It is highly soluble in water and does not need a particular carrier for its proper absorption in the body. It has a healing effect on wounds, particularly tendon and ligament tears, and injuries.


Potential uses of BPC-157

• Healing of gastric ulcers
• Correction of segmental bone defects
• Healing of corneal injuries
• Correction of colon-colon anastomosis and colocutaneous fistulas
• Healing skin burns
• treatment of various inflammatory conditions, particularly IBD and Crohn’s Disease
• Relieving pain from muscle sprains and ligament tears


What is TB-500?

TB-500 is a synthetically produced peptide derived from its naturally occurring parent peptide called the thymosin-beta peptide. It is a healing peptide present in the majority of the tissues present in mammalian bodies.

The thymus gland naturally produces the TB-500 peptide and has a high concentration in bodily fluids. It has shown healing properties in tissue-related injuries in skin and ligaments.


How Does TB-500 Work?

The healing properties of the peptide TB-500 are due to its ability to upregulate the protein actin. Since actin is the major protein involved in the proliferation and cellular migration, critical steps in the growth of new tissue, TB-500 aids recovery from injury. Overall, TB-500 also improves angiogenesis, has significant anti-inflammatory properties, and optimizes healing and recovery.

Potential Benefits of TB-500
• Healing skin burns and injuries
• Anti-inflammatory properties
• Aiding the recovery of slow-healing wounds such as those resulting from tendon and ligament injuries
• Promoting and enhancing flexibility


Potential of BPC-157 & TB-500 Blend in Wound Repair

Having described the healing properties of both peptides separately, extensive research reveals that using BPC-157 and TB-500 simultaneously for wound healing and regeneration can prove highly fruitful. Although both peptides act via different mechanisms, their combined use can cause a synergistic change in wound healing.


How BPC-157 & TB-500 Bring About Cellular Migration and Wound Healing

Fibroblasts are the essential cells that trigger wound healing in all tissue types. Fibroblasts are the cells that produce an extracellular matrix. For them to reach their desired location, they need a carrier. The carrier is usually a protein acting as a regulator of this process of cellular migration. This stage is where the peptides BPC-157 & TB-500 come into the picture. Both these peptides upregulate actin production. BPC-157 Brings about this upregulation via increased genetic transcription of the actin protein. At the same time, TB-500 acts as a binding protein to the actin. TB-500 accumulates where it is most required by binding to the actin protein. Together, these peptides increase the quantity of actin and improve its function. Therefore, the synergistic action of both the peptides enhances the rate at which actin protein and various other immune system cells migrate to the site of injury.

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